Q9V6B9 · NUP54_DROME
- ProteinProbable nucleoporin Nup54
- GeneNup54
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids610 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050).
Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050).
Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346).
By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs1Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346).
Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner (PubMed:17682050).
Together with Nup58, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346).
By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs1Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear pore | |
Cellular Component | nuclear pore central transport channel | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | mRNA transport | |
Biological Process | NLS-bearing protein import into nucleus | |
Biological Process | nuclear pore organization | |
Biological Process | nucleocytoplasmic transport | |
Biological Process | protein import into nucleus | |
Biological Process | protein localization to nuclear inner membrane | |
Biological Process | protein targeting |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable nucleoporin Nup54
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9V6B9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000204873 | 1-610 | Probable nucleoporin Nup54 | |||
Sequence: MSFFGSNTSLGATSTPAKTTGGLFGSPFGGTAATSQPAPAFGAQATSTPAFGAQPATSAFGAGSAFGATAAAPAFGAATGTSAFGGSAFGSTPAFGAATTTTAGTGLGGGGFGGFGAAPATSQAGLFGAPATSAAPPAFSGFGQQAAASTAPASGFSGFGTTTTSAPAFGGFGTSQSTGFGGGAFGSTFGKPANTTVTPGFGGFGGTSFMLGQPQQQPAPISADEAFAQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQSAAPVDITPENVMCRFKAIGYSRMPGKDNKLGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNMLVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRILATELSNYLNQATLKPQLNNLGVVEALALVLPDEDQLREYLENPPRGVDPRMWRQANSDNPDPTLYIPVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHATATAKILEHKRKLAELSHRILRIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFKGRLSELLSQMRMQRNQFAANGGAEYALDKEAEDEMKTFLTMQQRAMEVLSDTVNKDLRALDVIIKGLPELRQS |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the nuclear pore complex (PubMed:17682050).
Interacts with Nup58 (PubMed:33856346).
Interacts (via C-terminus) with fs1Yb; this interaction occurs in a RNA-independent manner (PubMed:33856346).
Interacts with sbr/nxf1 (PubMed:33856346).
Interacts with Nxt1 (PubMed:33856346).
Interacts with Nup58 (PubMed:33856346).
Interacts (via C-terminus) with fs1Yb; this interaction occurs in a RNA-independent manner (PubMed:33856346).
Interacts with sbr/nxf1 (PubMed:33856346).
Interacts with Nxt1 (PubMed:33856346).
Complex viewer
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 4-5 | 1 | ||||
Sequence: FG | ||||||
Region | 4-554 | 25 X 2 AA repeats of F-G | ||||
Sequence: FGSNTSLGATSTPAKTTGGLFGSPFGGTAATSQPAPAFGAQATSTPAFGAQPATSAFGAGSAFGATAAAPAFGAATGTSAFGGSAFGSTPAFGAATTTTAGTGLGGGGFGGFGAAPATSQAGLFGAPATSAAPPAFSGFGQQAAASTAPASGFSGFGTTTTSAPAFGGFGTSQSTGFGGGAFGSTFGKPANTTVTPGFGGFGGTSFMLGQPQQQPAPISADEAFAQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQSAAPVDITPENVMCRFKAIGYSRMPGKDNKLGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNMLVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRILATELSNYLNQATLKPQLNNLGVVEALALVLPDEDQLREYLENPPRGVDPRMWRQANSDNPDPTLYIPVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHATATAKILEHKRKLAELSHRILRIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFKGRLSELLSQMRMQRNQF | ||||||
Repeat | 24-25 | 2 | ||||
Sequence: FG | ||||||
Repeat | 28-29 | 3 | ||||
Sequence: FG | ||||||
Repeat | 41-42 | 4 | ||||
Sequence: FG | ||||||
Repeat | 51-52 | 5 | ||||
Sequence: FG | ||||||
Repeat | 60-61 | 6 | ||||
Sequence: FG | ||||||
Repeat | 66-67 | 7 | ||||
Sequence: FG | ||||||
Repeat | 75-76 | 8 | ||||
Sequence: FG | ||||||
Repeat | 84-85 | 9 | ||||
Sequence: FG | ||||||
Repeat | 89-90 | 10 | ||||
Sequence: FG | ||||||
Repeat | 95-96 | 11 | ||||
Sequence: FG | ||||||
Repeat | 112-113 | 12 | ||||
Sequence: FG | ||||||
Repeat | 115-116 | 13 | ||||
Sequence: FG | ||||||
Repeat | 127-128 | 14 | ||||
Sequence: FG | ||||||
Repeat | 142-143 | 15 | ||||
Sequence: FG | ||||||
Repeat | 159-160 | 16 | ||||
Sequence: FG | ||||||
Repeat | 169-170 | 17 | ||||
Sequence: FG | ||||||
Repeat | 172-173 | 18 | ||||
Sequence: FG | ||||||
Repeat | 180-181 | 19 | ||||
Sequence: FG | ||||||
Repeat | 185-186 | 20 | ||||
Sequence: FG | ||||||
Repeat | 189-190 | 21 | ||||
Sequence: FG | ||||||
Repeat | 201-202 | 22 | ||||
Sequence: FG | ||||||
Repeat | 204-205 | 23 | ||||
Sequence: FG | ||||||
Repeat | 237-238 | 24 | ||||
Sequence: FG | ||||||
Repeat | 324-325 | 25 | ||||
Sequence: FG |
Domain
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence similarities
Belongs to the NUP54 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length610
- Mass (Da)64,397
- Last updated2000-05-01 v1
- Checksum77D139079E6B4C01
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAF58509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY051713 EMBL· GenBank· DDBJ | AAK93137.1 EMBL· GenBank· DDBJ | mRNA |