Q9V4M2 · WECH_DROME

Function

function

Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites.

Miscellaneous

'Wech' means 'detached' or 'gone' in German.

Caution

Was originally termed dappled.

Features

Showing features for binding site.

1832100200300400500600700800
TypeIDPosition(s)Description
Binding site123Zn2+ 1 (UniProtKB | ChEBI)
Binding site126Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site149Zn2+ 1 (UniProtKB | ChEBI)
Binding site189Zn2+ 2 (UniProtKB | ChEBI)
Binding site192Zn2+ 2 (UniProtKB | ChEBI)
Binding site211Zn2+ 2 (UniProtKB | ChEBI)
Binding site216Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmuscle tendon junction
Molecular Functionprotein-macromolecule adaptor activity
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processinstar larval development
Biological Processmuscle attachment
Biological Processregulation of cell-cell adhesion mediated by integrin

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein wech
  • Alternative names
    • Protein dappled

Gene names

    • Name
      wech
    • Synonyms
      dpld
    • ORF names
      CG42396

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9V4M2
  • Secondary accessions
    • A4IJ45
    • B7YZS8
    • Q0E9G5
    • Q95SY8

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Muscle detachment in late-stage-16/early-stage-17 embryos.

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002203691-832Protein wech
Modified residue107Phosphoserine
Modified residue470Phosphoserine
Modified residue475Phosphoserine
Modified residue506Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed ubiquitously in all epithelial cells during early stages of embryogenesis. Specifically expressed at epidermal muscle attachment site.

Developmental stage

Expressed both maternally and zygotically throughout development.

Gene expression databases

    • FBgn0259745Expressed in cleaving embryo and 60 other cell types or tissues

Interaction

Subunit

Interacts with the head domain of rhea and the kinase domain of Ilk.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, zinc finger, repeat.

Type
IDPosition(s)Description
Region1-42Disordered
Zinc finger118-163B box-type 1
Zinc finger184-224B box-type 2
Repeat537-580NHL 1
Repeat584-627NHL 2
Repeat631-674NHL 3
Repeat680-722NHL 4
Repeat727-770NHL 5

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    832
  • Mass (Da)
    90,573
  • Last updated
    2002-10-01 v2
  • Checksum
    A5672AFC3FDE1FE1
MMELLSNNSVPQQMASSNAPSANNVAHSSTANGSGGGSVSSNASNSSERLLAGILESFPAWDLNVGLLPNVGQSSPPRADFFINNFLGGLDTHGDFSIGPIGSGARSNPKMSPESSNNSSISCGWCEVSASIRCLECNEFMCNDCLREHRNSPLSSNHSIVSLPTPIGASPTGGSSVNAQTPPSGNFICDIHNEMLRYVCDYCRKLVCQCCTLHEHKEHSYASIQSFMVGSKEKLEGAIESSQVGTRCIKSSIDKALAFIRLIERNCSELSDNIRKAFRQFIIAIEDRERFLLDFVEKLRQRRLAILHDQMAGLKSALAGLSETSDMLSKVADNACNMDQIEIAMKLTNGQRQMEQFAGIYKDLQPKQEVFAFAPPDYSLLQDIRNQGGVILVDDKNLPIVSSSNGIVPSVSSVNAVAAASVGVVGGVAGVVGGVGVSNGLDLAFGMNMPNNPLSVASSSVRRPLLRDNSFRIPSPIMQPRGGSACGMSSGMSSAALDWELNGLRSSPGLHFSAPRTTQAIPGCMDLVKVRNSNALSLSFATEGHEDGQVSRPWGLCVDKMGHVLVSDRRNNRVQVFNPDGSLKFKFGRKGVGNGEFDLPAGICVDVDNRIIVVDKDNHRVQIFTASGVFLLKFGSYGKEYGQFQYPWDVAVNSRRQIVVTDSRNHRIQQFDSEGRFIRQIVFDNHGQTKGIASPRGVCYTPTGNIIVSDFDNHCLYLIDPDINDILSVKGHEGSGFHEFNRPSGLCCDDEGRIIVADSKNQRILVFNQNLDFMWDIEVRPSINPLMPPTLDEKDRTCDVAIMPDGRIVFLIELSPDSKEGSNPYKRFVHVF

Sequence caution

The sequence AAL25460.1 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013599
EMBL· GenBank· DDBJ
AAF59246.2
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAM68901.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
ACL83068.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
ACL83069.1
EMBL· GenBank· DDBJ
Genomic DNA
AY060421
EMBL· GenBank· DDBJ
AAL25460.1
EMBL· GenBank· DDBJ
mRNA Frameshift
BT010087
EMBL· GenBank· DDBJ
AAQ22556.1
EMBL· GenBank· DDBJ
mRNA
BT030403
EMBL· GenBank· DDBJ
ABO52822.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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