Q9V4M2 · WECH_DROME
- ProteinProtein wech
- Genewech
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids832 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites.
Miscellaneous
'Wech' means 'detached' or 'gone' in German.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 123 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 126 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 145 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 149 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 189 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 192 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 211 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 216 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | muscle tendon junction | |
Molecular Function | protein-macromolecule adaptor activity | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | instar larval development | |
Biological Process | muscle attachment | |
Biological Process | regulation of cell-cell adhesion mediated by integrin |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein wech
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9V4M2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Muscle detachment in late-stage-16/early-stage-17 embryos.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000220369 | 1-832 | Protein wech | ||
Modified residue | 107 | Phosphoserine | |||
Modified residue | 470 | Phosphoserine | |||
Modified residue | 475 | Phosphoserine | |||
Modified residue | 506 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed ubiquitously in all epithelial cells during early stages of embryogenesis. Specifically expressed at epidermal muscle attachment site.
Developmental stage
Expressed both maternally and zygotically throughout development.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-42 | Disordered | |||
Zinc finger | 118-163 | B box-type 1 | |||
Zinc finger | 184-224 | B box-type 2 | |||
Repeat | 537-580 | NHL 1 | |||
Repeat | 584-627 | NHL 2 | |||
Repeat | 631-674 | NHL 3 | |||
Repeat | 680-722 | NHL 4 | |||
Repeat | 727-770 | NHL 5 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length832
- Mass (Da)90,573
- Last updated2002-10-01 v2
- ChecksumA5672AFC3FDE1FE1
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAF59246.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | ACL83068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | ACL83069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY060421 EMBL· GenBank· DDBJ | AAL25460.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BT010087 EMBL· GenBank· DDBJ | AAQ22556.1 EMBL· GenBank· DDBJ | mRNA | ||
BT030403 EMBL· GenBank· DDBJ | ABO52822.1 EMBL· GenBank· DDBJ | mRNA |