Q9V4K2 · GR43A_DROME

Function

function

Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies.

Features

Showing features for binding site.

142750100150200250300350400
TypeIDPosition(s)Description
Binding site70beta-D-fructose (UniProtKB | ChEBI)
Binding site83beta-D-fructose (UniProtKB | ChEBI)
Binding site182beta-D-fructose (UniProtKB | ChEBI)
Binding site310beta-D-fructose (UniProtKB | ChEBI)
Binding site337beta-D-fructose (UniProtKB | ChEBI)
Binding site421Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentdendrite
Cellular Componentmembrane
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Molecular Functionionotropic sweet taste receptor activity
Molecular Functionligand-gated monoatomic cation channel activity
Molecular Functionsweet taste receptor activity
Molecular Functiontaste receptor activity
Biological Processadult feeding behavior
Biological Processcellular response to fructose stimulus
Biological Processchemosensory behavior
Biological Processmale courtship behavior
Biological Processmonoatomic cation transmembrane transport
Biological Processregulation of appetite
Biological Processregulation of feeding behavior
Biological Processsensory perception of sweet taste
Biological Processsensory perception of taste
Biological Processsignal transduction

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Gustatory receptor for sugar taste 43a

Gene names

    • Name
      Gr43a
    • Synonyms
      GR43.1
    • ORF names
      CG1712

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9V4K2
  • Secondary accessions
    • Q4V4B7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-37Cytoplasmic
Transmembrane38-63Helical; Name=S1
Topological domain64-75Extracellular
Transmembrane76-96Helical; Name=S2
Topological domain97-135Cytoplasmic
Transmembrane136-158Helical; Name=S3
Topological domain159-168Extracellular
Transmembrane169-193Helical; Name=S4
Topological domain194-293Cytoplasmic
Transmembrane294-316Helical; Name=S5
Topological domain317-324Extracellular
Transmembrane325-346Helical; Name=S6
Topological domain347-402Cytoplasmic
Transmembrane403-423Helical; Name=S7b
Topological domain424-427Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis70Significantly reduces fructose-induced current.
Mutagenesis83Abolishes fructose-induced current.
Mutagenesis150Abolishes fructose-induced current.
Mutagenesis182Abolishes fructose-induced current.
Mutagenesis212No effect on fructose-induced current.
Mutagenesis266No effect on fructose-induced current.
Mutagenesis269No effect on fructose-induced current.
Mutagenesis286Increases conduit ion current amplitude significantly.
Mutagenesis306Significantly reduces fructose-induced current.
Mutagenesis310Abolishes fructose-induced current.
Mutagenesis333Abolishes fructose-induced current.
Mutagenesis337Abolishes fructose-induced current.
Mutagenesis353Reduces conduit ion current amplitude significantly.
Mutagenesis357Reduces conduit ion current amplitude significantly.
Mutagenesis360Reduces conduit ion current amplitude significantly.
Mutagenesis389Reduces conduit ion current amplitude significantly.
Mutagenesis393Reduces conduit ion current amplitude significantly.
Mutagenesis418Results in constitutive activation of the channel pore that is further activated when fructose binds.
Mutagenesis421Complete loss of function.
Mutagenesis421Low constitutive activity and loss of fructose sensitivity.
Mutagenesis422Deactivation of central channel pore that does not reactivate upon fructose binding.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002165141-427Gustatory receptor for sugar taste 43a

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the adult labellar chemosensory neurons and in the adult head, abdomen, leg and wing. In larvae, is expressed in taste organs, as well as the brain and the gastrointestinal system.

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    427
  • Mass (Da)
    47,573
  • Last updated
    2004-05-10 v3
  • Checksum
    19928FBA374AABAB
MEISQPSIGIFYISKVLALAPYATVRNSKGRVEIGRSWLFTVYSATLTVVMVFLTYRGLLFDANSEIPVRMKSATSKVVTALDVSVVVMAIVSGVYCGLFSLNDTLELNDRLNKIDNTLNAYNNFRRDRWRALGMAAVSLLAISILVGLDVGTWMRIAQDMNIAQSDTELNVHWYIPFYSLYFILTGLQVNIANTAYGLGRRFGRLNRMLSSSFLAENNATSAIKPQKVSTVKNVSVNRPAMPSALHASLTKLNGETLPSEAAAKNKGLLLKSLADSHESLGKCVHLLSNSFGIAVLFILVSCLLHLVATAYFLFLELLSKRDNGYLWVQMLWICFHFLRLLMVVEPCHLAARESRKTIQIVCEIERKVHEPILAEAVKKFWQQLLVVDADFSACGLCRVNRTILTSFASAIATYLVILIQFQRTNG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4LEE5A0A0B4LEE5_DROMEGr43a453
Q0E9G8Q0E9G8_DROMEGr43a449

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013599
EMBL· GenBank· DDBJ
AAF59268.3
EMBL· GenBank· DDBJ
Genomic DNA
BT023089
EMBL· GenBank· DDBJ
AAY55505.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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