Q9V1I3 · LYSK_PYRAB
- ProteinPutative [LysW]-lysine/[LysW]-ornithine hydrolase
- GenelysK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids337 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
Catalytic activity
- [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
Cofactor
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 Zn2+ or Co2+ ions per subunit.
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.
Amino-acid biosynthesis; L-arginine biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 67 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Active site | 69 | ||||
Binding site | 91 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 91 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Active site | 118 | Proton acceptor | |||
Binding site | 119 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 140 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 298 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cobalt ion binding | |
Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | |
Molecular Function | zinc ion binding | |
Biological Process | arginine biosynthetic process via ornithine | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative [LysW]-lysine/[LysW]-ornithine hydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Pyrococcus
Accessions
- Primary accessionQ9V1I3
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000185345 | 1-337 | Putative [LysW]-lysine/[LysW]-ornithine hydrolase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length337
- Mass (Da)37,448
- Last updated2000-05-01 v1
- ChecksumB082B30C55C524CB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ248284 EMBL· GenBank· DDBJ | CAB49366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE613800 EMBL· GenBank· DDBJ | CCE69826.1 EMBL· GenBank· DDBJ | Genomic DNA |