Q9V0N0 · PANE_PYRAB
- Protein2-dehydropantoate 2-reductase
- GeneapbA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids300 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
Catalytic activity
- (R)-pantoate + NAD+ = 2-dehydropantoate + H+ + NADHThis reaction proceeds in the backward direction.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-12 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GAGAIG | ||||||
Binding site | 74 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 99 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 123 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Active site | 179 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 179 | substrate | ||||
Sequence: K | ||||||
Binding site | 183 | substrate | ||||
Sequence: N | ||||||
Binding site | 187 | substrate | ||||
Sequence: N | ||||||
Binding site | 197 | substrate | ||||
Sequence: N | ||||||
Binding site | 246-249 | substrate | ||||
Sequence: NYNS | ||||||
Binding site | 261 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 2-dehydropantoate 2-reductase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-dehydropantoate 2-reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Pyrococcus
Accessions
- Primary accessionQ9V0N0
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000157325 | 1-300 | 2-dehydropantoate 2-reductase | |||
Sequence: MKIYILGAGAIGSLFGGLLANAGEDVLLIGRDPHVSAINEKGLKIVGIKDLNVKVEATTRVPEEKPDLIVLATKSYSTIEALKSARHIVKGSWVLSIQNGIGNEDKIIEFGGKAIGGITTNGAMVEAPGVIKWTGKGVTIIGLYPQGKEKFIEKVADVFNSADIETHVSENIISWIWAKAIVNSAINPIGTLLEVKNKVIRENDFLLSMAMEVVKEGCRVALQNGIEFDVPPMDLFFQTLEQTRENYNSMLQDIWRGKKTEVDYINGKIVEYAKAVNLEAPMNLLLWGLIKGKEALEGKK |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)32,773
- Last updated2000-05-01 v1
- ChecksumF559625B73F691DC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ248285 EMBL· GenBank· DDBJ | CAB49673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE613800 EMBL· GenBank· DDBJ | CCE70155.1 EMBL· GenBank· DDBJ | Genomic DNA |