Q9UZQ4 · THIM_PYRAB
- ProteinHydroxyethylthiazole kinase
- GenethiM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids265 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Catalytic activity
- 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H+
Cofactor
Pathway
Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | hydroxyethylthiazole kinase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | thiamine biosynthetic process | |
Biological Process | thiamine diphosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxyethylthiazole kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Pyrococcus
Accessions
- Primary accessionQ9UZQ4
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000156970 | 1-265 | Hydroxyethylthiazole kinase | |||
Sequence: MNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKLLERVTGTGCIVTAITGAFVAVTEPLRAAISSLVVFGIAAEKAYEEAKYPGSFHVKLYDWLYRIDGEVIRKYAKVREVGV |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length265
- Mass (Da)28,705
- Last updated2012-05-16 v2
- Checksum5E7C4084BA3C5A18
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ248286 EMBL· GenBank· DDBJ | CAB50002.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
HE613800 EMBL· GenBank· DDBJ | CCE70504.1 EMBL· GenBank· DDBJ | Genomic DNA |