Q9UW19 · MTAL1_CANAL

Function

function

Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha-specific mating genes.

Miscellaneous

The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA). MTLALPHA1 is not represented in the genomic sequence of strain SC5314 because that haploid assembly includes the mating type a allele of this locus.
Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.

Features

Showing features for dna binding.

119320406080100120140160180
TypeIDPosition(s)Description
DNA binding86-142Alpha box

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding, bending
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionsequence-specific DNA binding
Biological Processpositive regulation of mating-type specific transcription, DNA-templated

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mating-type-like protein ALPHA1
  • Short names
    MTLalpha1 protein

Gene names

    • Name
      MTLALPHA1
    • ORF names
      CaO19.10712
    • Ordered locus names
      C5_01755C_B

Organism names

Accessions

  • Primary accession
    Q9UW19
  • Secondary accessions
    • Q59YW6

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002060071-193Mating-type-like protein ALPHA1

Expression

Induction

Induced by HBR1 in response to hemoglobin and growth signals.

Family & Domains

Sequence similarities

Belongs to the MATALPHA1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    22,456
  • Last updated
    2000-05-01 v1
  • Checksum
    980E7E2EA8C7A2AB
MGNKKKTRKTVPKEFISLFRVHSGRDAPRRDTREVQKSKKHGFRFTSLPDLPVASNALQELLLEYGLLNDIKWDSKGLKASKNKKTKLKPINSFIAFRSFYSRTISNPEHQRELSSKLADVWTQESNQEVWKQYTQSYNNYLLLPDAKLNFVDWLCEALDYTIDNTTPQIEDISLTSYNQLLSGTIEDVYIMK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF167163
EMBL· GenBank· DDBJ
AAD51411.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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