Q9UW19 · MTAL1_CANAL
- ProteinMating-type-like protein ALPHA1
- GeneMTLALPHA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids193 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha-specific mating genes.
Miscellaneous
The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA). MTLALPHA1 is not represented in the genomic sequence of strain SC5314 because that haploid assembly includes the mating type a allele of this locus.
Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 86-142 | Alpha box | ||||
Sequence: TKLKPINSFIAFRSFYSRTISNPEHQRELSSKLADVWTQESNQEVWKQYTQSYNNYL |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding, bending | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | positive regulation of mating-type specific transcription, DNA-templated |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMating-type-like protein ALPHA1
- Short namesMTLalpha1 protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ9UW19
- Secondary accessions
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000206007 | 1-193 | Mating-type-like protein ALPHA1 | |||
Sequence: MGNKKKTRKTVPKEFISLFRVHSGRDAPRRDTREVQKSKKHGFRFTSLPDLPVASNALQELLLEYGLLNDIKWDSKGLKASKNKKTKLKPINSFIAFRSFYSRTISNPEHQRELSSKLADVWTQESNQEVWKQYTQSYNNYLLLPDAKLNFVDWLCEALDYTIDNTTPQIEDISLTSYNQLLSGTIEDVYIMK |
Expression
Induction
Induced by HBR1 in response to hemoglobin and growth signals.
Structure
Sequence
- Sequence statusComplete
- Length193
- Mass (Da)22,456
- Last updated2000-05-01 v1
- Checksum980E7E2EA8C7A2AB