Q9UUQ6 · LCPS_MUCCL

Function

function

Bifunctional enzyme that catalyzes the reactions from prephytoene diphosphate to phytoene and lycopene to beta-carotene via the intermediate gamma-carotene.

Catalytic activity

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.
Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Function15-cis-phytoene synthase activity
Molecular Functionfarnesyl-diphosphate farnesyltransferase activity
Molecular Functionfarnesyltranstransferase activity
Molecular Functiongeranylgeranyl-diphosphate geranylgeranyltransferase activity
Molecular Functionintramolecular lyase activity
Molecular Functionlycopene beta cyclase activity
Biological Processcarotenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional lycopene cyclase/phytoene synthase

Including 2 domains:

  • Recommended name
    Lycopene beta-cyclase
  • EC number
  • Recommended name
    Phytoene synthase
  • EC number

Gene names

    • Name
      CARRP

Organism names

Accessions

  • Primary accession
    Q9UUQ6

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2-22Helical
Transmembrane36-56Helical
Transmembrane70-90Helical
Transmembrane120-140Helical
Transmembrane143-163Helical
Transmembrane174-194Helical
Transmembrane217-237Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant78in strain: MS21; loss of lycopene cyclase activity
Natural variant86in strain: MS35; loss of lycopene cyclase activity
Natural variant409in strain: MS36; loss of phytoene cyclase activity

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000674411-614Bifunctional lycopene cyclase/phytoene synthase

Expression

Induction

By blue light.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-239Lycopene beta-cyclase
Region246-614Phytoene synthase

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    614
  • Mass (Da)
    69,841
  • Last updated
    2000-05-01 v1
  • Checksum
    599E6BB541087FE5
MLLTYMEVHLYYTLPVLGVLSWLSRPYYTATDALKFKFLTLVAFTTASAWDNYIVYHKAWSYCPTCVTAVIGYVPLEEYMFFIIMTLLTVAFTNLVMRWHLHSFFIRPETPVMQSVLVRLVPITALLITAYKAWHLAVPGKPLFYGSCILWYACPVLALLWFGAGEYMMRRPLAVLVSIALPTLFLCWVDVVAIGAGTWDISLATSTGKFVVPHLPVEEFMFFALINTVLVFGTCAIDRTMAILHLFKNKSPYQRPYQHSKSFLHQILEMTWAFCLPDQVLHSDTFHDLSVSWDILRKASKSFYTASAVFPGDVRQELGVLYAFCRATDDLCDNEQVPVQTRKEQLILTHQFVSDLFGQKTSAPTAIDWDFYNDQLPASCISAFKSFTRLRHVLEAGAIKELLDGYKWDLERRSIRDQEDLRYYSACVASSVGEMCTRIILAHADKPASRQQTQWIIQRAREMGLVLQYTNIARDIVTDSEELGRCYLPQDWLTEKEVALIQGGLAREIGEERLLSLSHRLIYQADELMVVANKGIDKLPSHCQGGVRAACNVYASIGTKLKSYKHHYPSRAHVGNSKRVEIALLSVYNLYTAPIATSSTTHCRQGKMRNLNTI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ250827
EMBL· GenBank· DDBJ
CAB60272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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