Q9UUQ6 · LCPS_MUCCL
- ProteinBifunctional lycopene cyclase/phytoene synthase
- GeneCARRP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids614 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Bifunctional enzyme that catalyzes the reactions from prephytoene diphosphate to phytoene and lycopene to beta-carotene via the intermediate gamma-carotene.
Catalytic activity
- all-trans-lycopene = gamma-carotene
Pathway
Carotenoid biosynthesis; beta-carotene biosynthesis.
Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 15-cis-phytoene synthase activity | |
Molecular Function | farnesyl-diphosphate farnesyltransferase activity | |
Molecular Function | farnesyltranstransferase activity | |
Molecular Function | geranylgeranyl-diphosphate geranylgeranyltransferase activity | |
Molecular Function | intramolecular lyase activity | |
Molecular Function | lycopene beta cyclase activity | |
Biological Process | carotenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional lycopene cyclase/phytoene synthase
Including 2 domains:
- Recommended nameLycopene beta-cyclase
- EC number
- Recommended namePhytoene synthase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Mucorineae > Mucoraceae > Mucor
Accessions
- Primary accessionQ9UUQ6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2-22 | Helical | ||||
Sequence: LLTYMEVHLYYTLPVLGVLSW | ||||||
Transmembrane | 36-56 | Helical | ||||
Sequence: FKFLTLVAFTTASAWDNYIVY | ||||||
Transmembrane | 70-90 | Helical | ||||
Sequence: VIGYVPLEEYMFFIIMTLLTV | ||||||
Transmembrane | 120-140 | Helical | ||||
Sequence: LVPITALLITAYKAWHLAVPG | ||||||
Transmembrane | 143-163 | Helical | ||||
Sequence: LFYGSCILWYACPVLALLWFG | ||||||
Transmembrane | 174-194 | Helical | ||||
Sequence: AVLVSIALPTLFLCWVDVVAI | ||||||
Transmembrane | 217-237 | Helical | ||||
Sequence: VEEFMFFALINTVLVFGTCAI |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 78 | in strain: MS21; loss of lycopene cyclase activity | ||||
Sequence: E → K | ||||||
Natural variant | 86 | in strain: MS35; loss of lycopene cyclase activity | ||||
Sequence: T → I | ||||||
Natural variant | 409 | in strain: MS36; loss of phytoene cyclase activity | ||||
Sequence: D → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000067441 | 1-614 | Bifunctional lycopene cyclase/phytoene synthase | |||
Sequence: MLLTYMEVHLYYTLPVLGVLSWLSRPYYTATDALKFKFLTLVAFTTASAWDNYIVYHKAWSYCPTCVTAVIGYVPLEEYMFFIIMTLLTVAFTNLVMRWHLHSFFIRPETPVMQSVLVRLVPITALLITAYKAWHLAVPGKPLFYGSCILWYACPVLALLWFGAGEYMMRRPLAVLVSIALPTLFLCWVDVVAIGAGTWDISLATSTGKFVVPHLPVEEFMFFALINTVLVFGTCAIDRTMAILHLFKNKSPYQRPYQHSKSFLHQILEMTWAFCLPDQVLHSDTFHDLSVSWDILRKASKSFYTASAVFPGDVRQELGVLYAFCRATDDLCDNEQVPVQTRKEQLILTHQFVSDLFGQKTSAPTAIDWDFYNDQLPASCISAFKSFTRLRHVLEAGAIKELLDGYKWDLERRSIRDQEDLRYYSACVASSVGEMCTRIILAHADKPASRQQTQWIIQRAREMGLVLQYTNIARDIVTDSEELGRCYLPQDWLTEKEVALIQGGLAREIGEERLLSLSHRLIYQADELMVVANKGIDKLPSHCQGGVRAACNVYASIGTKLKSYKHHYPSRAHVGNSKRVEIALLSVYNLYTAPIATSSTTHCRQGKMRNLNTI |
Expression
Induction
By blue light.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-239 | Lycopene beta-cyclase | ||||
Sequence: MLLTYMEVHLYYTLPVLGVLSWLSRPYYTATDALKFKFLTLVAFTTASAWDNYIVYHKAWSYCPTCVTAVIGYVPLEEYMFFIIMTLLTVAFTNLVMRWHLHSFFIRPETPVMQSVLVRLVPITALLITAYKAWHLAVPGKPLFYGSCILWYACPVLALLWFGAGEYMMRRPLAVLVSIALPTLFLCWVDVVAIGAGTWDISLATSTGKFVVPHLPVEEFMFFALINTVLVFGTCAIDR | ||||||
Region | 246-614 | Phytoene synthase | ||||
Sequence: LFKNKSPYQRPYQHSKSFLHQILEMTWAFCLPDQVLHSDTFHDLSVSWDILRKASKSFYTASAVFPGDVRQELGVLYAFCRATDDLCDNEQVPVQTRKEQLILTHQFVSDLFGQKTSAPTAIDWDFYNDQLPASCISAFKSFTRLRHVLEAGAIKELLDGYKWDLERRSIRDQEDLRYYSACVASSVGEMCTRIILAHADKPASRQQTQWIIQRAREMGLVLQYTNIARDIVTDSEELGRCYLPQDWLTEKEVALIQGGLAREIGEERLLSLSHRLIYQADELMVVANKGIDKLPSHCQGGVRAACNVYASIGTKLKSYKHHYPSRAHVGNSKRVEIALLSVYNLYTAPIATSSTTHCRQGKMRNLNTI |
Sequence similarities
In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length614
- Mass (Da)69,841
- Last updated2000-05-01 v1
- Checksum599E6BB541087FE5