Q9UTJ7 · SDHA_SCHPO
- ProteinProbable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- Genesdh1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids641 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Catalytic activity
- a quinone + succinate = fumarate + a quinol
Cofactor
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 61-66 | FAD (UniProtKB | ChEBI) | |||
Binding site | 84-99 | FAD (UniProtKB | ChEBI) | |||
Binding site | 268 | FAD (UniProtKB | ChEBI) | |||
Binding site | 289 | substrate | |||
Binding site | 301 | substrate | |||
Active site | 333 | Proton acceptor | |||
Binding site | 400 | substrate | |||
Binding site | 434 | FAD (UniProtKB | ChEBI) | |||
Binding site | 445 | substrate | |||
Binding site | 450-451 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Cellular Component | respiratory chain complex II (succinate dehydrogenase) | |
Molecular Function | electron transfer activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | succinate dehydrogenase (quinone) activity | |
Biological Process | mitochondrial electron transport, succinate to ubiquinone | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionQ9UTJ7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, transit peptide, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000010341 | ?-641 | Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | ||
Transit peptide | 1-? | Mitochondrion | |||
Modified residue | 92 | Tele-8alpha-FAD histidine | |||
Proteomic databases
PTM databases
Interaction
Subunit
Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
Complex viewer
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length641
- Mass (Da)70,466
- Last updated2000-05-01 v1
- Checksum5E5FCD857C372199
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 214 | in Ref. 2; BAA13924 | |||
Sequence conflict | 218 | in Ref. 2; BAA13924 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329670 EMBL· GenBank· DDBJ | CAB61213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
D89263 EMBL· GenBank· DDBJ | BAA13924.1 EMBL· GenBank· DDBJ | mRNA |