Q9UTJ7 · SDHA_SCHPO

Function

function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site61-66FAD (UniProtKB | ChEBI)
Binding site84-99FAD (UniProtKB | ChEBI)
Binding site268FAD (UniProtKB | ChEBI)
Binding site289substrate
Binding site301substrate
Active site333Proton acceptor
Binding site400substrate
Binding site434FAD (UniProtKB | ChEBI)
Binding site445substrate
Binding site450-451FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Cellular Componentrespiratory chain complex II (succinate dehydrogenase)
Molecular Functionelectron transfer activity
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionsuccinate dehydrogenase (quinone) activity
Biological Processmitochondrial electron transport, succinate to ubiquinone
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
  • EC number
  • Alternative names
    • Flavoprotein subunit of complex II (FP)

Gene names

    • Name
      sdh1
    • ORF names
      SPAC1556.02c

Organism names

Accessions

  • Primary accession
    Q9UTJ7
  • Secondary accessions
    • P78912

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, transit peptide, modified residue.

Type
IDPosition(s)Description
ChainPRO_0000010341?-641Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Transit peptide1-?Mitochondrion
Modified residue92Tele-8alpha-FAD histidine

Proteomic databases

PTM databases

Interaction

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Complex viewer

View interactors in UniProtKB
View CPX-566 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    641
  • Mass (Da)
    70,466
  • Last updated
    2000-05-01 v1
  • Checksum
    5E5FCD857C372199
MLRFRKVAPSLKNGGNLKLFSTSSTLKKIASSQPLRAKQVSTSESVKYPVIDHTYDAIVVGAGGAGLRATFGLAEAGFNTACITKLFPTRSHTVAAQGGINAALGNMTKDDWRWHFYDTVKGSDWLGDQDAIHYMTKEAPKAVLELEHFGVPFSRTKEGKIYQRAFGGQSLEYGKGGQAYRCAAVADRTGHSILHTLYGQSLKHNTNFFIEYFAMDLIMEGGECRGVIAMNLEDGSIHRFRAHKTILATGGYGRAYFSCTSAHTCTGDGNAMVSRAGLPLQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLLNSKGERFMERYAPTAKDLASRDVVSRAMTVEIREGRGVGPEKDHCYLQLSHLPAEILKERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTRFTGEVLTIDENGKDKIVPGLYAAGEAACVSVHGGNRLGANSLLDIVVFGRACALHIKDTLEPNTPHKPLAADAGLDSLKFLDQIRTSQGPKHTSEIRLDMQKTMQRDVSVFRMEETLQEGVKNIARVDGTYKDIGIRDRGLIWNTDLVEALELRNLLTCAVQTANAALNRKESRGAHAREDYPERDDKNWIKHTLTWQHKTGDPVTLKYRAVTRTTMDENEVKPVPPFKRVY

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict214in Ref. 2; BAA13924
Sequence conflict218in Ref. 2; BAA13924

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU329670
EMBL· GenBank· DDBJ
CAB61213.1
EMBL· GenBank· DDBJ
Genomic DNA
D89263
EMBL· GenBank· DDBJ
BAA13924.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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