Q9UQW6 · ERG10_SCHPO

Function

function

Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity).
Erg10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (By similarity).
The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase eg10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases erg13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hcs1 (Probable)

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site90Acyl-thioester intermediate
Binding site185CoA (UniProtKB | ChEBI)
Binding site185K+ (UniProtKB | ChEBI)
Binding site230CoA (UniProtKB | ChEBI)
Binding site246K+ (UniProtKB | ChEBI)
Binding site247K+ (UniProtKB | ChEBI)
Binding site249K+ (UniProtKB | ChEBI)
Binding site250CoA (UniProtKB | ChEBI)
Binding site347K+ (UniProtKB | ChEBI)
Active site351Proton acceptor
Active site381Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionacetyl-CoA C-acetyltransferase activity
Molecular Functionmetal ion binding
Biological Processergosterol biosynthetic process
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-CoA acetyltransferase
  • EC number
  • Alternative names
    • Acetoacetyl-CoA thiolase
    • Ergosterol biosynthesis protein 10

Gene names

    • Name
      erg10
    • ORF names
      SPBC215.09c

Organism names

Accessions

  • Primary accession
    Q9UQW6
  • Secondary accessions
    • P78835
    • Q1L848

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003103951-395Acetyl-CoA acetyltransferase

Proteomic databases

PTM databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    395
  • Mass (Da)
    40,998
  • Last updated
    2000-05-01 v1
  • Checksum
    382822A9EF686544
MVNTEVYIVSAVRTPMGSFGGSFASLPATKLGSIAIKGALERVNIKPSDVDEVFMGNVVSANLGQNPARQCALGAGLPRSIVCTTVNKVCASGMKATILGAQTIMTGNAEIVVAGGTESMSNAPYYAPKNRFGAKYGNVELVDGLLRDGLSDAYDGLPMGNAAELCAEEHSIDRASQDAFAISSYKRAQNAQATKAFEQEIVPVEVPVGRGKPNKLVTEDEEPKNLNEDKLKSVRAVFKSNGTVTAANASTLNDGASALVLMSAAKVKELGLKPLAKIIGWGEAAQDPERFTTSPSLAIPKALKHAGIEASQVDYYEINEAFSVVAVANTKILGLDPERVNINGGGVAMGHPLGSSGSRIICTLAYILAQKDAKIGVAAVCNGGGGASSIVIERV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict387in Ref. 1; BAA13846

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D89184
EMBL· GenBank· DDBJ
BAA13846.1
EMBL· GenBank· DDBJ
mRNA
CU329671
EMBL· GenBank· DDBJ
CAA22123.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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