Q9ULW6 · NP1L2_HUMAN
- ProteinNucleosome assembly protein 1-like 2
- GeneNAP1L2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids460 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acidic protein which may be involved in interactions with other proteins or DNA.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | histone acetyltransferase regulator activity | |
Molecular Function | histone binding | |
Biological Process | neuron differentiation | |
Biological Process | nucleosome assembly | |
Biological Process | positive regulation of neuron differentiation | |
Biological Process | regulation of stem cell division |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleosome assembly protein 1-like 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9ULW6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 420 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000185655 | 1-460 | Nucleosome assembly protein 1-like 2 | |||
Sequence: MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9ULW6 | CCDC146 Q8IYE0 | 3 | EBI-3911716, EBI-10749669 | |
BINARY | Q9ULW6 | CCDC185 Q8N715 | 3 | EBI-3911716, EBI-740814 | |
BINARY | Q9ULW6 | DMAP1 Q9NPF5 | 3 | EBI-3911716, EBI-399105 | |
BINARY | Q9ULW6 | FAM81A Q8TBF8 | 3 | EBI-3911716, EBI-11993062 | |
BINARY | Q9ULW6 | HTT P42858 | 3 | EBI-3911716, EBI-466029 | |
BINARY | Q9ULW6 | KLHL2 O95198 | 3 | EBI-3911716, EBI-746999 | |
BINARY | Q9ULW6 | MED30 Q96HR3 | 3 | EBI-3911716, EBI-394659 | |
BINARY | Q9ULW6 | NAP1L1 P55209 | 3 | EBI-3911716, EBI-356392 | |
BINARY | Q9ULW6 | NAP1L3 Q99457 | 4 | EBI-3911716, EBI-8645631 | |
BINARY | Q9ULW6 | NAP1L5 Q96NT1 | 5 | EBI-3911716, EBI-713627 | |
BINARY | Q9ULW6 | PPP1R13B Q96KQ4 | 3 | EBI-3911716, EBI-1105153 | |
XENO | Q9ULW6 | PRO_0000037551 Q9WMX2 | 2 | EBI-3911716, EBI-6863748 | |
BINARY | Q9ULW6 | SCNM1 Q9BWG6 | 3 | EBI-3911716, EBI-748391 | |
BINARY | Q9ULW6 | SH3BP5 O60239 | 3 | EBI-3911716, EBI-624860 | |
BINARY | Q9ULW6 | TP53BP2 Q05BL1 | 3 | EBI-3911716, EBI-11952721 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-88 | Disordered | ||||
Sequence: MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRP | ||||||
Compositional bias | 28-43 | Basic and acidic residues | ||||
Sequence: GEHLERGEDAAAGLGD | ||||||
Compositional bias | 67-88 | Basic and acidic residues | ||||
Sequence: AGSGEDGKKGGDTDEDSEADRP | ||||||
Compositional bias | 214-230 | Acidic residues | ||||
Sequence: EEEEEEEEDDIEATGEE | ||||||
Region | 214-238 | Disordered | ||||
Sequence: EEEEEEEEDDIEATGEENKEEEDPK | ||||||
Motif | 346-352 | Nuclear localization signal | ||||
Sequence: IKKKQKH |
Sequence similarities
Belongs to the nucleosome assembly protein (NAP) family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9ULW6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length460
- Mass (Da)52,542
- Last updated2000-05-01 v1
- Checksum36BE77964B5096C6
Q9ULW6-2
- Name2
- Differences from canonical
- 1-142: Missing
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057064 | 1-142 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 3 | in Ref. 7; AAH26325 | ||||
Sequence: E → K | ||||||
Compositional bias | 28-43 | Basic and acidic residues | ||||
Sequence: GEHLERGEDAAAGLGD | ||||||
Compositional bias | 67-88 | Basic and acidic residues | ||||
Sequence: AGSGEDGKKGGDTDEDSEADRP | ||||||
Compositional bias | 214-230 | Acidic residues | ||||
Sequence: EEEEEEEEDDIEATGEE |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB027013 EMBL· GenBank· DDBJ | BAA84706.1 EMBL· GenBank· DDBJ | mRNA | ||
AF136178 EMBL· GenBank· DDBJ | AAP97268.1 EMBL· GenBank· DDBJ | mRNA | ||
CR457095 EMBL· GenBank· DDBJ | CAG33376.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303676 EMBL· GenBank· DDBJ | BAG64673.1 EMBL· GenBank· DDBJ | mRNA | ||
AK316569 EMBL· GenBank· DDBJ | BAG38158.1 EMBL· GenBank· DDBJ | mRNA | ||
AC004074 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471104 EMBL· GenBank· DDBJ | EAW98670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC026325 EMBL· GenBank· DDBJ | AAH26325.1 EMBL· GenBank· DDBJ | mRNA |