Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein.Boyer T.G., Martin M.E.D., Lees E., Ricciardi R.P., Berk A.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH E1A AND CDK8CategoriesFunction, Sequences, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 399:276-279 (1999)Cited in1
Ras induces mediator complex exchange on C/EBP beta.Mo X., Kowenz-Leutz E., Xu H., Leutz A.View abstractCited forFUNCTION, INTERACTION WITH CEBPBCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 13:241-250 (2004)Cited in2Mapped to5
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly.Baek H.J., Kang Y.K., Roeder R.G.View abstractCited forFUNCTION, INTERACTION WITH MED1 AND MED10CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 281:15172-15181 (2006)Cited in9Mapped to1
The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.Yuan C.-X., Ito M., Fondell J.D., Fu Z.-Y., Roeder R.G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 95:7939-7944 (1998)Cited in2Mapped to72
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.Rachez C., Suldan Z., Ward J., Chang C.-P.B., Burakov D., Erdjument-Bromage H., Tempst P., Freedman L.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCGenes Dev. 12:1787-1800 (1998)Cited in1Mapped to21
Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.Mukherjee R., Jow L., Croston G.E., Paterniti J.R. Jr.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCJ. Biol. Chem. 272:8071-8076 (1997)Cited in1Mapped to60
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.Lemberger T., Desvergne B., Wahli W.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCAnnu Rev Cell Dev Biol 12:335-363 (1996)Mapped to47
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.De Vos P., Lefebvre A.M., Miller S.G., Guerre-Millo M., Wong K., Saladin R., Hamann L.G., Staels B., Briggs M.R., Auwerx J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCJ Clin Invest 98:1004-1009 (1996)Mapped to45
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.Lambe K.G., Tugwood J.D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCEur. J. Biochem. 239:1-7 (1996)Cited in1Mapped to46
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.Miller S.G., De Vos P., Guerre-Millo M., Wong K., Hermann T., Staels B., Briggs M.R., Auwerx J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCProc Natl Acad Sci U S A 93:5507-5511 (1996)Mapped to45
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor.Tontonoz P., Hu E., Spiegelman B.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCCell 79:1147-1156 (1994)Mapped to47
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.Tontonoz P., Graves R.A., Budavari A.I., Erdjument-Bromage H., Lui M., Hu E., Tempst P., Spiegelman B.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCNucleic Acids Res. 22:5628-5634 (1994)Cited in2Mapped to62
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.Yeh W.C., Cao Z., Classon M., McKnight S.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCGenes Dev 9:168-181 (1995)Mapped to65
An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25.Van Royen T., Sedeyn K., Moschonas G.D., Toussaint W., Vuylsteke M., Van Haver D., Impens F., Eyckerman S., Lemmens I.[...], Saelens X.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCJ Virol 96:e0129722-e0129722 (2022)Mapped to54
Respiratory Syncytial Virus NS1 Protein Targets the Transactivator Binding Domain of MED25.Dong J., Basse V., Bierre M., Peres de Oliveira A., Vidalain P.O., Sibille P., Tangy F., Galloux M., Eleouet J.F.[...], Bajorek M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCJ Mol Biol 434:167763-167763 (2022)Mapped to32
Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription.Pei J., Beri N.R., Zou A.J., Hubel P., Dorando H.K., Bergant V., Andrews R.D., Pan J., Andrews J.M.[...], Leung D.W.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCCell Rep 37:109803-109803 (2021)Mapped to321
Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma.Guo Y., Wang J., Li H., Liu W., Chen D., Zhao K., Liang X., Zhang Q., Yang Y., Chen G.View abstractAnnotationMED23 plays an important role in hepatocarcinogenesis and it may be a novel target for HCC therapy.CategoriesFunctionSourceGeneRif: 9439PubMedEurope PMCJ Gastroenterol Hepatol 30:1094-1103 (2015)Mapped to14
Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.Shi J., Liu H., Yao F., Zhong C., Zhao H.View abstractAnnotationUpregulation of mediator MED23 in non-small-cell lung cancer promotes the growth migration and metastasis of cancer cells.CategoriesFunctionSourceGeneRif: 9439PubMedEurope PMCTumour Biol 35:12005-12013 (2014)Mapped to14
Selective requirement for Mediator MED23 in Ras-active lung cancer.Yang X., Zhao M., Xia M., Liu Y., Yan J., Ji H., Wang G.View abstractAnnotationData show that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity.CategoriesFunction, Disease & VariantsSourceGeneRif: 9439PubMedEurope PMCProc Natl Acad Sci U S A 109:E2813-22 (2012)Mapped to41
The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology.Wu W., Tran K.C., Teng M.N., Heesom K.J., Matthews D.A., Barr J.N., Hiscox J.A.View abstractAnnotationPathwayCategoriesInteraction, FunctionSourceIntAct: Q9ULK4, Reactome: R-HSA-556823PubMedEurope PMCJ Virol 86:7777-7789 (2012)Mapped to99+
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.Kelleher R.J., Flanagan P.M., Kornberg R.D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCCell 61:1209-1215 (1990)Mapped to22
Propagation of adipogenic signals through an epigenomic transition state.Steger D.J., Grant G.R., Schupp M., Tomaru T., Lefterova M.I., Schug J., Manduchi E., Stoeckert C.J. Jr., Lazar M.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCGenes Dev 24:1035-1044 (2010)Mapped to47
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.Grontved L., Madsen M.S., Boergesen M., Roeder R.G., Mandrup S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCMol Cell Biol 30:2155-2169 (2010)Mapped to63
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression.Morganstein D.L., Wu P., Mane M.R., Fisk N.M., White R., Parker M.G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCCell Res 20:434-444 (2010)Mapped to46
Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.Tian L., Zhou J., Casimiro M.C., Liang B., Ojeifo J.O., Wang M., Hyslop T., Wang C., Pestell R.G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-556823PubMedEurope PMCCancer Res 69:9236-9244 (2009)Mapped to52