Q9UL68 · MYT1L_HUMAN

  • Protein
    Myelin transcription factor 1-like protein
  • Gene
    MYT1L
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.

Features

Showing features for binding site.

111861002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site31Zn2+ 1 (UniProtKB | ChEBI)
Binding site36Zn2+ 1 (UniProtKB | ChEBI)
Binding site49Zn2+ 1 (UniProtKB | ChEBI)
Binding site55Zn2+ 1 (UniProtKB | ChEBI)
Binding site506Zn2+ 2 (UniProtKB | ChEBI)
Binding site511Zn2+ 2 (UniProtKB | ChEBI)
Binding site524Zn2+ 2 (UniProtKB | ChEBI)
Binding site530Zn2+ 2 (UniProtKB | ChEBI)
Binding site550Zn2+ 3 (UniProtKB | ChEBI)
Binding site555Zn2+ 3 (UniProtKB | ChEBI)
Binding site568Zn2+ 3 (UniProtKB | ChEBI)
Binding site574Zn2+ 3 (UniProtKB | ChEBI)
Binding site905Zn2+ 4 (UniProtKB | ChEBI)
Binding site910Zn2+ 4 (UniProtKB | ChEBI)
Binding site923Zn2+ 4 (UniProtKB | ChEBI)
Binding site929Zn2+ 4 (UniProtKB | ChEBI)
Binding site954Zn2+ 5 (UniProtKB | ChEBI)
Binding site959Zn2+ 5 (UniProtKB | ChEBI)
Binding site972Zn2+ 5 (UniProtKB | ChEBI)
Binding site978Zn2+ 5 (UniProtKB | ChEBI)
Binding site1007Zn2+ 6 (UniProtKB | ChEBI)
Binding site1012Zn2+ 6 (UniProtKB | ChEBI)
Binding site1025Zn2+ 6 (UniProtKB | ChEBI)
Binding site1031Zn2+ 6 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionzinc ion binding
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnervous system development
Biological Processneuron development
Biological Processneuron differentiation
Biological Processneuron fate commitment
Biological Processneuron fate specification
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myelin transcription factor 1-like protein
  • Short names
    MyT1-L
    ; MyT1L

Gene names

    • Name
      MYT1L
    • Synonyms
      KIAA1106

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9UL68
  • Secondary accessions
    • A7E2C7
    • B2RP54
    • Q6IQ17
    • Q9UPP6

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Chromosome
Note: Preferentially binds to DNA binding sites that are in an open chromatin configuration.

Keywords

Disease & Variants

Involvement in disease

Intellectual developmental disorder, autosomal dominant 39 (MRD39)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.
  • See also
    MIM:616521

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,410 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000966731-1186Myelin transcription factor 1-like protein
Modified residue250Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with SIN3B.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, zinc finger, coiled coil.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Region1-21Disordered
Zinc finger22-65CCHHC-type 1
Region56-175Disordered
Compositional bias89-169Acidic residues
Region220-247Disordered
Compositional bias342-358Polar residues
Region342-372Disordered
Compositional bias449-507Basic and acidic residues
Region449-513Disordered
Zinc finger497-540CCHHC-type 2
Zinc finger541-584CCHHC-type 3
Region659-709Disordered
Compositional bias684-709Polar residues
Region753-780Disordered
Zinc finger896-939CCHHC-type 4
Zinc finger945-988CCHHC-type 5
Zinc finger998-1041CCHHC-type 6
Coiled coil1056-1130

Sequence similarities

Belongs to the MYT1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9UL68-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,186
  • Mass (Da)
    133,043
  • Last updated
    2011-04-05 v3
  • Checksum
    AEF068692263FA8C
MEVDTEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENMNDRNYADSMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPRSRVFASCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMEAGRRDNMRSYEDQSPRQLPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSSQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSPQQQAVMNNRCFQLGEGDCWDLPVDYTKMKPRRIDEDESKDITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV

Q9UL68-3

Q9UL68-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 36 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8YF72A0A2R8YF72_HUMANMYT1L1207
Q49A74Q49A74_HUMANMYT1L109
R4GMY9R4GMY9_HUMANMYT1L521
H7BYU4H7BYU4_HUMANMYT1L181
A0A3B3IRX0A0A3B3IRX0_HUMANMYT1L943
A0A3B3IRX5A0A3B3IRX5_HUMANMYT1L1146
A0A3B3IS97A0A3B3IS97_HUMANMYT1L236
A0A3B3IS14A0A3B3IS14_HUMANMYT1L1186
A0A3B3IRQ0A0A3B3IRQ0_HUMANMYT1L69
A0A3B3IRR4A0A3B3IRR4_HUMANMYT1L102
A0A3B3IS21A0A3B3IS21_HUMANMYT1L335
A0A3B3IRT9A0A3B3IRT9_HUMANMYT1L1127
A0A3B3IS61A0A3B3IS61_HUMANMYT1L1148
A0A3B3IS77A0A3B3IS77_HUMANMYT1L982
A0A3B3ISI4A0A3B3ISI4_HUMANMYT1L516
A0A3B3ISN1A0A3B3ISN1_HUMANMYT1L677
A0A3B3ISN3A0A3B3ISN3_HUMANMYT1L824
A0A3B3ISP2A0A3B3ISP2_HUMANMYT1L859
A0A3B3ISB6A0A3B3ISB6_HUMANMYT1L754
A0A3B3IT20A0A3B3IT20_HUMANMYT1L88
A0A3B3ISG9A0A3B3ISG9_HUMANMYT1L247
A0A3B3ISU4A0A3B3ISU4_HUMANMYT1L243
A0A3B3ISU9A0A3B3ISU9_HUMANMYT1L56
A0A3B3ISW5A0A3B3ISW5_HUMANMYT1L1143
A0A3B3ITL3A0A3B3ITL3_HUMANMYT1L860
A0A3B3ITJ8A0A3B3ITJ8_HUMANMYT1L1185
A0A3B3ITS6A0A3B3ITS6_HUMANMYT1L677
A0A3B3ITT2A0A3B3ITT2_HUMANMYT1L69
A0A3B3IU66A0A3B3IU66_HUMANMYT1L739
A0A3B3IU83A0A3B3IU83_HUMANMYT1L519
A0A3B3IUE2A0A3B3IUE2_HUMANMYT1L973
A0A8I5KQG8A0A8I5KQG8_HUMANMYT1L108
A0A3B3IRJ2A0A3B3IRJ2_HUMANMYT1L53
A0A3B3IRK4A0A3B3IRK4_HUMANMYT1L492
A0A3B3IRM3A0A3B3IRM3_HUMANMYT1L1143
A0A3B3IRF0A0A3B3IRF0_HUMANMYT1L669

Sequence caution

The sequence AAF14051.1 differs from that shown. Reason: Frameshift
The sequence AAI50282.1 differs from that shown. Reason: Miscellaneous discrepancy Aberrant splicing.
The sequence BAA83058.2 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence BAA83058.2 differs from that shown. Reason: Miscellaneous discrepancy Aberrant splicing.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Alternative sequenceVSP_0157221-1004in isoform 3
Compositional bias89-169Acidic residues
Sequence conflict108-159in Ref. 2; BAA83058 and 5; AAI50282
Sequence conflict191in Ref. 1; AAF14051
Compositional bias342-358Polar residues
Compositional bias449-507Basic and acidic residues
Alternative sequenceVSP_015724493-494in isoform 4
Compositional bias684-709Polar residues
Sequence conflict935in Ref. 1; AAF14051
Sequence conflict987in Ref. 1; AAF14051
Alternative sequenceVSP_0157251092in isoform 3
Sequence conflict1110in Ref. 1; AAF14051

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF036943
EMBL· GenBank· DDBJ
AAF14051.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AB029029
EMBL· GenBank· DDBJ
BAA83058.2
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AC008276
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC009232
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC009471
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC011301
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC093390
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC106046
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC071612
EMBL· GenBank· DDBJ
AAH71612.1
EMBL· GenBank· DDBJ
mRNA
BC137272
EMBL· GenBank· DDBJ
AAI37273.1
EMBL· GenBank· DDBJ
mRNA
BC137273
EMBL· GenBank· DDBJ
AAI37274.1
EMBL· GenBank· DDBJ
mRNA
BC150281
EMBL· GenBank· DDBJ
AAI50282.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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