Q9UL59 · ZN214_HUMAN
- ProteinZinc finger protein 214
- GeneZNF214
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids606 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence AVTFEDVTIIFTWEEWKFLDSSQKRLYREVMWENYTNVMSVENWNESYKSQEEKFRYLEYENFSYWQGWWNAGAQMYENQ, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 214
- Alternative names
Gene names
- Community suggested namesZNF214
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UL59
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_057403 | 66 | in dbSNP:rs1156526 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_019975 | 128 | in dbSNP:rs1156525 | |||
Sequence: L → H | ||||||
Natural variant | VAR_057404 | 160 | in dbSNP:rs16921097 | |||
Sequence: H → R | ||||||
Natural variant | VAR_019976 | 185 | in dbSNP:rs2239734 | |||
Sequence: I → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 867 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047458 | 1-606 | Zinc finger protein 214 | |||
Sequence: MAVTFEDVTIIFTWEEWKFLDSSQKRLYREVMWENYTNVMSVENWNESYKSQEEKFRYLEYENFSYWQGWWNAGAQMYENQNYGETVQGTDSKDLTQQDRSQCQEWLILSTQVPGYGNYELTFESKSLRNLKYKNFMPWQSLETKTTQDYGREIYMSGSHGFQGGRYRLGISRKNLSMEKEQKLIVQHSYIPVEEALPQYVGVICQEDLLRDSMEEKYCGCNKCKGIYYWNSRCVFHKRNQPGENLCQCSICKACFSQRSDLYRHPRNHIGKKLYGCDEVDGNFHQSSGVHFHQRVHIGEVPYSCNACGKSFSQISSLHNHQRVHTEEKFYKIECDKDLSRNSLLHIHQRLHIGEKPFKCNQCGKSFNRSSVLHVHQRVHTGEKPYKCDECGKGFSQSSNLRIHQLVHTGEKSYKCEDCGKGFTQRSNLQIHQRVHTGEKPYKCDDCGKDFSHSSDLRIHQRVHTGEKPYTCPECGKGFSKSSKLHTHQRVHTGEKPYKCEECGKGFSQRSHLLIHQRVHTGEKPYKCHDCGKGFSHSSNLHIHQRVHTGEKPYQCAKCGKGFSHSSALRIHQRVHAGEKPYKCREYYKGFDHNSHLHNNHRRGNL |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-83 | KRAB | ||||
Sequence: VTFEDVTIIFTWEEWKFLDSSQKRLYREVMWENYTNVMSVENWNESYKSQEEKFRYLEYENFSYWQGWWNAGAQMYENQNY | ||||||
Zinc finger | 275-297 | C2H2-type 1; degenerate | ||||
Sequence: YGCDEVDGNFHQSSGVHFHQRVH | ||||||
Zinc finger | 303-325 | C2H2-type 2 | ||||
Sequence: YSCNACGKSFSQISSLHNHQRVH | ||||||
Zinc finger | 330-352 | C2H2-type 3; degenerate | ||||
Sequence: FYKIECDKDLSRNSLLHIHQRLH | ||||||
Zinc finger | 358-380 | C2H2-type 4 | ||||
Sequence: FKCNQCGKSFNRSSVLHVHQRVH | ||||||
Zinc finger | 386-408 | C2H2-type 5 | ||||
Sequence: YKCDECGKGFSQSSNLRIHQLVH | ||||||
Zinc finger | 414-436 | C2H2-type 6 | ||||
Sequence: YKCEDCGKGFTQRSNLQIHQRVH | ||||||
Zinc finger | 442-464 | C2H2-type 7 | ||||
Sequence: YKCDDCGKDFSHSSDLRIHQRVH | ||||||
Zinc finger | 470-492 | C2H2-type 8 | ||||
Sequence: YTCPECGKGFSKSSKLHTHQRVH | ||||||
Zinc finger | 498-520 | C2H2-type 9 | ||||
Sequence: YKCEECGKGFSQRSHLLIHQRVH | ||||||
Zinc finger | 526-548 | C2H2-type 10 | ||||
Sequence: YKCHDCGKGFSHSSNLHIHQRVH | ||||||
Zinc finger | 554-576 | C2H2-type 11 | ||||
Sequence: YQCAKCGKGFSHSSALRIHQRVH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length606
- Mass (Da)70,992
- Last updated2010-05-18 v2
- ChecksumD0CBA2E0F9E3EAB2
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 252 | in Ref. 1; AAF00004, 2; BAG36248 and 4; AAI36773 | ||||
Sequence: C → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF056617 EMBL· GenBank· DDBJ | AAF00004.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313462 EMBL· GenBank· DDBJ | BAG36248.1 EMBL· GenBank· DDBJ | mRNA | ||
AC100875 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC136772 EMBL· GenBank· DDBJ | AAI36773.1 EMBL· GenBank· DDBJ | mRNA |