Q9UL54 · TAOK2_HUMAN
- ProteinSerine/threonine-protein kinase TAO2
- GeneTAOK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1235 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase TAO2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UL54
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 2
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 965-985 | Helical | ||||
Sequence: LLPLLLLLLLPLLAAQGGGGL | ||||||
Transmembrane | 987-1007 | Helical | ||||
Sequence: AALLALEVGLVGLGASYLLLC | ||||||
Transmembrane | 1012-1032 | Helical | ||||
Sequence: LPSSLFLLLAQGTALGAVLGL | ||||||
Transmembrane | 1043-1063 | Helical | ||||
Sequence: LGLGAAWLLAWPGLALPLVAM | ||||||
Transmembrane | 1166-1186 | Helical | ||||
Sequence: QGLASHLPPWAIHTLASWGLL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 57 | Loss of kinase activity. In isoform 1, excluded from the nucleus. No effect on microtubule-binding. | ||||
Sequence: K → A | ||||||
Mutagenesis | 169 | Loss of kinase activity; No effect on MAP3K7-mediated activation of NF-kappa-B. | ||||
Sequence: D → A | ||||||
Mutagenesis | 919 | No effect on kinase activity, nor on JNK activation, but severe reduction in nuclear localization and apoptotic membrane blebbing. | ||||
Sequence: D → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,189 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000086733 | 1-1235 | UniProt | Serine/threonine-protein kinase TAO2 | |||
Sequence: MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR | |||||||
Modified residue | 9 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 9 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 43 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 181 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 181 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 309 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 414 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 473 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 486 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 493 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 604 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 656 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 656 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 777 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 777 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 825 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 825 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 827 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 827 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1011 | UniProt | In isoform Q9UL54-2; Phosphoserine | ||||
Sequence: H | |||||||
Modified residue | 1031 | UniProt | In isoform Q9UL54-2; Phosphoserine | ||||
Sequence: G |
Post-translational modification
Isoform 2
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interferes with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9UL54 | CIDEB Q9UHD4 | 3 | EBI-352832, EBI-7062247 | |
BINARY | Q9UL54 | KRTAP6-3 Q3LI67 | 3 | EBI-352832, EBI-22311199 | |
BINARY | Q9UL54 | MAPRE3 Q9UPY8 | 3 | EBI-352832, EBI-726739 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-281 | Protein kinase | ||||
Sequence: FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV | ||||||
Region | 318-457 | Disordered | ||||
Sequence: QEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRR | ||||||
Compositional bias | 344-373 | Polar residues | ||||
Sequence: TLTSLESSHSVPSMSISASSQSSSVNSLAD | ||||||
Compositional bias | 374-395 | Acidic residues | ||||
Sequence: ASDNEEEEEEEEEEEEEEEGPE | ||||||
Coiled coil | 486-547 | |||||
Sequence: SALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQ | ||||||
Coiled coil | 574-601 | |||||
Sequence: KELAALLEAQKRTYKLRKEQLKEELQEN | ||||||
Coiled coil | 681-713 | |||||
Sequence: LRQHEATRELELRQLQAVQRTRAELTRLQHQTE | ||||||
Region | 732-777 | Disordered | ||||
Sequence: HAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCS | ||||||
Region | 804-835 | Disordered | ||||
Sequence: KEGATLEPKQQRILGEESGAPSPSPQKHGSLV | ||||||
Region | 891-939 | Disordered | ||||
Sequence: QGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCP | ||||||
Compositional bias | 920-938 | Pro residues | ||||
Sequence: GCPSPDIPPEPPPTHLRPC | ||||||
Region | 1198-1235 | Disordered | ||||
Sequence: LPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q9UL54-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsPSK1-alpha, TAO2
- Length1,235
- Mass (Da)138,251
- Last updated2006-10-17 v2
- Checksum211852E690934307
Q9UL54-2
- Name2
- SynonymsPSK1-beta
- Differences from canonical
- 745-1049: VRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAW → SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRSTSVASHILNGSSHFYS
- 1050-1235: Missing
Q9UL54-3
- Name3
Q9UL54-4
- Name4
- Differences from canonical
- 745-857: Missing
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_015967 | 1-173 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_015968 | 174-218 | in isoform 3 | |||
Sequence: SIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL → MMGTSQGHVARKSRNWGLNPSRLSSIPLSSTPCHLSPSSLSPFSV | ||||||
Sequence conflict | 189 | in Ref. 7; AAI51222/AAI42664 | ||||
Sequence: M → T | ||||||
Compositional bias | 344-373 | Polar residues | ||||
Sequence: TLTSLESSHSVPSMSISASSQSSSVNSLAD | ||||||
Compositional bias | 374-395 | Acidic residues | ||||
Sequence: ASDNEEEEEEEEEEEEEEEGPE | ||||||
Alternative sequence | VSP_044894 | 745-857 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_015969 | 745-1049 | in isoform 2 | |||
Sequence: VRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAW → SKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPPGMPPPAWRQPSLLAPPGPPNWLGPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSENVGPPAAAVPGPLSRSTSVASHILNGSSHFYS | ||||||
Compositional bias | 920-938 | Pro residues | ||||
Sequence: GCPSPDIPPEPPPTHLRPC | ||||||
Alternative sequence | VSP_015970 | 1050-1235 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 1211 | in Ref. 1; AAD45616 | ||||
Sequence: R → H |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF061943 EMBL· GenBank· DDBJ | AAD45616.1 EMBL· GenBank· DDBJ | mRNA | ||
AF263313 EMBL· GenBank· DDBJ | AAG38503.1 EMBL· GenBank· DDBJ | mRNA | ||
AB020688 EMBL· GenBank· DDBJ | BAA74904.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK291473 EMBL· GenBank· DDBJ | BAF84162.1 EMBL· GenBank· DDBJ | mRNA | ||
AL137701 EMBL· GenBank· DDBJ | CAB70882.1 EMBL· GenBank· DDBJ | mRNA | ||
AC093512 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471238 EMBL· GenBank· DDBJ | EAW79963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471238 EMBL· GenBank· DDBJ | EAW79964.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC136653 EMBL· GenBank· DDBJ | AAI36654.1 EMBL· GenBank· DDBJ | mRNA | ||
BC136655 EMBL· GenBank· DDBJ | AAI36656.1 EMBL· GenBank· DDBJ | mRNA | ||
BC142663 EMBL· GenBank· DDBJ | AAI42664.1 EMBL· GenBank· DDBJ | mRNA | ||
BC144344 EMBL· GenBank· DDBJ | AAI44345.1 EMBL· GenBank· DDBJ | mRNA | ||
BC151221 EMBL· GenBank· DDBJ | AAI51222.1 EMBL· GenBank· DDBJ | mRNA | ||
BC152413 EMBL· GenBank· DDBJ | AAI52414.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358942 EMBL· GenBank· DDBJ | AAQ89301.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |