Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.Scott D.C., Rhee D.Y., Duda D.M., Kelsall I.R., Olszewski J.L., Paulo J.A., de Jong A., Ovaa H., Alpi A.F.[...], Schulman B.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCCell 166:1198-1214 (2016)Cited in9Mapped to64
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.Keuss M.J., Thomas Y., Mcarthur R., Wood N.T., Knebel A., Kurz T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ. Cell Sci. 129:1441-1454 (2016)Cited in17Mapped to99+
Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.Yu C., Mao H., Novitsky E.J., Tang X., Rychnovsky S.D., Zheng N., Huang L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCNat. Commun. 6:10053-10053 (2015)Cited in1Mapped to99+
Protein neddylation: beyond cullin-RING ligases.Enchev R.I., Schulman B.A., Peter M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCNat Rev Mol Cell Biol 16:30-44 (2015)Mapped to99+
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.Freund A., Zhong F.L., Venteicher A.S., Meng Z., Veenstra T.D., Frydman J., Artandi S.E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCCell 159:1389-1403 (2014)Cited in9Mapped to36
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.Phillips-Krawczak C.A., Singla A., Starokadomskyy P., Deng Z., Osborne D.G., Li H., Dick C.J., Gomez T.S., Koenecke M.[...], Burstein E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCMol. Biol. Cell 26:91-103 (2015)Cited in15Mapped to99+
SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).Huang G., Stock C., Bommelje C.C., Weeda V.B., Shah K., Bains S., Buss E., Shaha M., Rechler W.[...], Singh B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ. Biol. Chem. 289:34728-34742 (2014)Cited in7Mapped to99+
Cullin E3 ligases and their rewiring by viral factors.Mahon C., Krogan N.J., Craik C.S., Pick E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCBiomolecules 4:897-930 (2014)Mapped to99+
Modulation of STAT3 folding and function by TRiC/CCT chaperonin.Kasembeli M., Lau W.C., Roh S.H., Eckols T.K., Frydman J., Chiu W., Tweardy D.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCPLoS Biol 12:e1001844-e1001844 (2014)Mapped to54
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin- RING ligase complexes.Kelsall I.R., Duda D.M., Olszewski J.L., Hofmann K., Knebel A., Langevin F., Wood N., Wightman M., Schulman B.A., Alpi A.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCEMBO J. 32:2848-2860 (2013)Cited in7Mapped to99+
Interaction of p53 with the CCT complex promotes protein folding and wild- type p53 activity.Trinidad A.G., Muller P.A., Cuellar J., Klejnot M., Nobis M., Valpuesta J.M., Vousden K.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCMol Cell 50:805-817 (2013)Mapped to99+
Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers.Gummlich L., Rabien A., Jung K., Dubiel W.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCInt J Biochem Cell Biol 45:1327-1337 (2013)Mapped to99+
CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.Starokadomskyy P., Gluck N., Li H., Chen B., Wallis M., Maine G.N., Mao X., Zaidi I.W., Hein M.Y.[...], Burstein E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ. Clin. Invest. 123:2244-2256 (2013)Cited in11Mapped to99+
CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.Wu S., Zhu W., Nhan T., Toth J.I., Petroski M.D., Wolf D.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCNat Commun 4:1642-1642 (2013)Mapped to99+
CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.Zemla A., Thomas Y., Kedziora S., Knebel A., Wood N.T., Rabut G., Kurz T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCNat Commun 4:1641-1641 (2013)Mapped to99+
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.Pierce N.W., Lee J.E., Liu X., Sweredoski M.J., Graham R.L., Larimore E.A., Rome M., Zheng N., Clurman B.E.[...], Deshaies R.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCCell 153:206-215 (2013)Cited in1Mapped to99+
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.Monda J.K., Scott D.C., Miller D.J., Lydeard J., King D., Harper J.W., Bennett E.J., Schulman B.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCStructure 21:42-53 (2013)Cited in13Mapped to99+
Structural basis for a reciprocal regulation between SCF and CSN.Enchev R.I., Scott D.C., da Fonseca P.C., Schreiber A., Monda J.K., Schulman B.A., Peter M., Morris E.P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCCell Rep 2:616-627 (2012)Mapped to99+
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.Taipale M., Krykbaeva I., Koeva M., Kayatekin C., Westover K.D., Karras G.I., Lindquist S.View abstractCategoriesInteractionSourceIntAct: Q9UKT5PubMedEurope PMCCell 150:987-1001 (2012)Mapped to99+
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.Scott D.C., Monda J.K., Bennett E.J., Harper J.W., Schulman B.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCScience 334:674-678 (2011)Cited in5Mapped to99+
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis.Lipkowitz S., Weissman A.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCNat Rev Cancer 11:629-643 (2011)Mapped to99+
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8- dissociated protein 1) binding.Mao X., Gluck N., Chen B., Starokadomskyy P., Li H., Maine G.N., Burstein E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ. Biol. Chem. 286:32355-32365 (2011)Cited in11Mapped to99+
Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.Boh B.K., Smith P.G., Hagen T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ Mol Biol 409:136-145 (2011)Mapped to99+
Mechanisms of ubiquitin transfer by the anaphase-promoting complex.Matyskiela M.E., Rodrigo-Brenni M.C., Morgan D.O.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCJ Biol 8:92-92 (2009)Mapped to99+
F-box-directed CRL complex assembly and regulation by the CSN and CAND1.Schmidt M.W., McQuary P.R., Wee S., Hofmann K., Wolf D.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-391298PubMedEurope PMCMol. Cell 35:586-597 (2009)Cited in1Mapped to99+