Q9UKR3 · KLK13_HUMAN

  • Protein
    Kallikrein-13
  • Gene
    KLK13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Features

Showing features for active site.

127720406080100120140160180200220240260
TypeIDPosition(s)Description
Active site76Charge relay system
Active site124Charge relay system
Active site218Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentsecretory granule
Molecular Functionhydrolase activity
Molecular Functionserine-type endopeptidase activity
Biological Processprotein processing
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Kallikrein-13
  • EC number
  • Alternative names
    • Kallikrein-like protein 4 (KLK-L4)

Gene names

    • Name
      KLK13
    • Synonyms
      KLKL4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9UKR3
  • Secondary accessions
    • A7UNK6
    • Q86VI8
    • Q9Y433

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_051857109in dbSNP:rs34089525

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 336 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000002795717-277Kallikrein-13
Glycosylation30N-linked (GlcNAc...) asparagine
Disulfide bond42↔178
Disulfide bond61↔77
Disulfide bond157↔224
Disulfide bond189↔203
Disulfide bond214↔239
Glycosylation225N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in prostate, breast, testis and salivary gland.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-263Peptidase S1

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q9UKR3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    277
  • Mass (Da)
    30,570
  • Last updated
    2000-05-01 v1
  • Checksum
    BA8A9E8DCFB5D542
MWPLALVIASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRKYETQQQKWLKGPQ

Q9UKR3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q5BQ95Q5BQ95_HUMANKLK1398
Q5BQ97Q5BQ97_HUMANKLK1393
Q5BQ99Q5BQ99_HUMANKLK1399
Q86VI7Q86VI7_HUMANKLK13204
M0R218M0R218_HUMANKLK13180

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_05663118-169in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF135024
EMBL· GenBank· DDBJ
AAD26425.2
EMBL· GenBank· DDBJ
Genomic DNA
AB108823
EMBL· GenBank· DDBJ
BAC75825.1
EMBL· GenBank· DDBJ
mRNA
EU091477
EMBL· GenBank· DDBJ
ABU63130.1
EMBL· GenBank· DDBJ
Genomic DNA
AC011473
EMBL· GenBank· DDBJ
AAG23259.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471135
EMBL· GenBank· DDBJ
EAW71979.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069334
EMBL· GenBank· DDBJ
AAH69334.1
EMBL· GenBank· DDBJ
mRNA
BC069543
EMBL· GenBank· DDBJ
AAH69543.1
EMBL· GenBank· DDBJ
mRNA
AL050220
EMBL· GenBank· DDBJ
CAB43320.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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