Q9UKJ5 · CHIC2_HUMAN

  • Protein
    Cysteine-rich hydrophobic domain-containing protein 2
  • Gene
    CHIC2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Features

Showing features for site.

116520406080100120140160
TypeIDPosition(s)Description
Site111-112Breakpoint for translocation to form CHIC2-ETV6 in AML

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi-associated vesicle
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentplasma membrane

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine-rich hydrophobic domain-containing protein 2
  • Alternative names
    • BrX-like translocated in leukemia

Gene names

    • Name
      CHIC2
    • Synonyms
      BTL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9UKJ5
  • Secondary accessions
    • B2R639

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
Cytoplasmic vesicle
Note: Also present at a Golgi-like vesicular compartment and at scattered vesicles.

Keywords

Disease & Variants

Involvement in disease

  • A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis88-95Loss of palmitoylation. Abolishes membrane association.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 134 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001895561-165Cysteine-rich hydrophobic domain-containing protein 2

Post-translational modification

Palmitoylation in the CHIC motif is required for membrane association.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9UKJ5ADAMTSL4 Q6UY14-33EBI-741528, EBI-10173507
BINARY Q9UKJ5AGXT P215493EBI-741528, EBI-727098
BINARY Q9UKJ5AXIN2 Q9Y2T13EBI-741528, EBI-4400025
BINARY Q9UKJ5C1QTNF2 Q9BXJ53EBI-741528, EBI-2817707
BINARY Q9UKJ5CARD10 Q9BWT73EBI-741528, EBI-3866279
BINARY Q9UKJ5CATSPER1 Q8NEC54EBI-741528, EBI-744545
BINARY Q9UKJ5CBY2 Q8NA613EBI-741528, EBI-741724
BINARY Q9UKJ5CDR2 Q018507EBI-741528, EBI-1181367
BINARY Q9UKJ5CEP44 Q9C0F13EBI-741528, EBI-744115
BINARY Q9UKJ5CYSRT1 A8MQ033EBI-741528, EBI-3867333
BINARY Q9UKJ5DNAL4 O960153EBI-741528, EBI-742362
BINARY Q9UKJ5ENKD1 Q9H0I23EBI-741528, EBI-744099
BINARY Q9UKJ5FBLN1 P23142-43EBI-741528, EBI-11956479
BINARY Q9UKJ5FLJ13057 Q53SE73EBI-741528, EBI-10172181
BINARY Q9UKJ5GMCL1 Q96IK53EBI-741528, EBI-2548508
BINARY Q9UKJ5HOXA1 P496394EBI-741528, EBI-740785
BINARY Q9UKJ5KANK2 Q63ZY33EBI-741528, EBI-2556193
BINARY Q9UKJ5KRT40 Q6A1623EBI-741528, EBI-10171697
BINARY Q9UKJ5KRTAP1-1 Q076273EBI-741528, EBI-11959885
BINARY Q9UKJ5KRTAP1-3 Q8IUG13EBI-741528, EBI-11749135
BINARY Q9UKJ5KRTAP10-7 P604093EBI-741528, EBI-10172290
BINARY Q9UKJ5KRTAP10-8 P604106EBI-741528, EBI-10171774
BINARY Q9UKJ5KRTAP10-9 P604113EBI-741528, EBI-10172052
BINARY Q9UKJ5KRTAP12-3 P603283EBI-741528, EBI-11953334
BINARY Q9UKJ5KRTAP2-4 Q9BYR93EBI-741528, EBI-14065470
BINARY Q9UKJ5KRTAP4-2 Q9BYR53EBI-741528, EBI-10172511
BINARY Q9UKJ5KRTAP5-9 P263716EBI-741528, EBI-3958099
BINARY Q9UKJ5KRTAP6-2 Q3LI663EBI-741528, EBI-11962084
BINARY Q9UKJ5LCE1A Q5T7P23EBI-741528, EBI-11962058
BINARY Q9UKJ5LCE1C Q5T7513EBI-741528, EBI-12224199
BINARY Q9UKJ5LCE1F Q5T7543EBI-741528, EBI-11958008
BINARY Q9UKJ5LCE2C Q5TA813EBI-741528, EBI-11973993
BINARY Q9UKJ5LCE3A Q5TA763EBI-741528, EBI-9394625
BINARY Q9UKJ5LCE3C Q5T5A86EBI-741528, EBI-10245291
BINARY Q9UKJ5LCE3D Q9BYE33EBI-741528, EBI-6658837
BINARY Q9UKJ5LCE5A Q5TCM93EBI-741528, EBI-11955689
BINARY Q9UKJ5LCN2 P801883EBI-741528, EBI-11911016
BINARY Q9UKJ5LZTS2 Q9BRK43EBI-741528, EBI-741037
BINARY Q9UKJ5MEOX2 P502223EBI-741528, EBI-748397
BINARY Q9UKJ5MEOX2 Q6FHY53EBI-741528, EBI-16439278
BINARY Q9UKJ5MTUS2 Q5JR59-33EBI-741528, EBI-11522433
BINARY Q9UKJ5MYF5 P133493EBI-741528, EBI-17491620
BINARY Q9UKJ5MYPOP Q86VE03EBI-741528, EBI-2858213
BINARY Q9UKJ5NDUFB7 P175683EBI-741528, EBI-1246238
BINARY Q9UKJ5NOTCH2NLA Q7Z3S93EBI-741528, EBI-945833
BINARY Q9UKJ5NOTCH2NLC P0DPK43EBI-741528, EBI-22310682
BINARY Q9UKJ5OTX1 P322424EBI-741528, EBI-740446
BINARY Q9UKJ5PLEKHF1 Q96S993EBI-741528, EBI-745767
BINARY Q9UKJ5PLEKHF2 Q9H8W43EBI-741528, EBI-742388
BINARY Q9UKJ5PLEKHG4 Q58EX73EBI-741528, EBI-949255
BINARY Q9UKJ5PNMA1 Q8ND903EBI-741528, EBI-302345
BINARY Q9UKJ5POU4F2 Q128373EBI-741528, EBI-17236143
BINARY Q9UKJ5REL Q04864-23EBI-741528, EBI-10829018
BINARY Q9UKJ5SCNM1 Q9BWG63EBI-741528, EBI-748391
BINARY Q9UKJ5SDCBP O005603EBI-741528, EBI-727004
BINARY Q9UKJ5TCF4 P158843EBI-741528, EBI-533224
BINARY Q9UKJ5ZNF330 Q9Y3S23EBI-741528, EBI-373456
BINARY Q9UKJ5ZNF837 Q96EG33EBI-741528, EBI-11962574

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for coiled coil, motif.

TypeIDPosition(s)Description
Coiled coil1-26
Motif88-106CHIC motif (Cys-rich)

Sequence similarities

Belongs to the CHIC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    165
  • Mass (Da)
    19,254
  • Last updated
    2000-05-01 v1
  • Checksum
    DC32A9C58524B55E
MADFDEIYEEEEDEERALEEQLLKYSPDPVVVRGSGHVTVFGLSNKFESEFPSSLTGKVAPEEFKASINRVNSCLKKNLPVNVRWLLCGCLCCCCTLGCSMWPVICLSKRTRRSIEKLLEWENNRLYHKLCLHWRLSKRKCETNNMMEYVILIEFLPKTPIFRPD

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RDW7D6RDW7_HUMANCHIC2146
H0Y8H1H0Y8H1_HUMANCHIC2137

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF159423
EMBL· GenBank· DDBJ
AAD55981.1
EMBL· GenBank· DDBJ
mRNA
AK312427
EMBL· GenBank· DDBJ
BAG35336.1
EMBL· GenBank· DDBJ
mRNA
CH471057
EMBL· GenBank· DDBJ
EAX05453.1
EMBL· GenBank· DDBJ
Genomic DNA
BC034691
EMBL· GenBank· DDBJ
AAH34691.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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