AIRE which is phosphorylated on two specific residues near its N terminus then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE increases its binding to the positive transcription elongation factor b (P-TEFb) and potentiates its transcriptional activity.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.