Geminin, an inhibitor of DNA replication, is degraded during mitosis.McGarry T.J., Kirschner M.W.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCCell 93:1043-1053 (1998)Cited in22Mapped to68
DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.Takahashi A., Imai Y., Yamakoshi K., Kuninaka S., Ohtani N., Yoshimoto S., Hori S., Tachibana M., Anderton E.[...], Hara E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCMol Cell 45:123-131 (2012)Mapped to63
CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).Lee S., Miller M., Shuman J.D., Johnson P.F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCJ Biol Chem 285:21399-21410 (2010)Mapped to81
Mechanisms of ubiquitin transfer by the anaphase-promoting complex.Matyskiela M.E., Rodrigo-Brenni M.C., Morgan D.O.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCJ Biol 8:92-92 (2009)Mapped to99+
RING domain E3 ubiquitin ligases.Deshaies R.J., Joazeiro C.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCAnnu Rev Biochem 78:399-434 (2009)Mapped to99+
Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.Ebstein F., Lange N., Urban S., Seifert U., Krueger E., Kloetzel P.-M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCInt. J. Biochem. Cell Biol. 41:1205-1215 (2009)Cited in1Mapped to99+
The APC/C inhibitor, Emi1, is essential for prevention of rereplication.Machida Y.J., Dutta A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCGenes Dev. 21:184-194 (2007)Cited in1Mapped to67
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.Binne U.K., Classon M.K., Dick F.A., Wei W., Rape M., Kaelin W.G. Jr., Naar A.M., Dyson N.J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCNat Cell Biol 9:225-232 (2007)Mapped to66
A novel family of membrane-bound E3 ubiquitin ligases.Ohmura-Hoshino M., Goto E., Matsuki Y., Aoki M., Mito M., Uematsu M., Hotta H., Ishido S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCJ Biochem 140:147-154 (2006)Mapped to99+
The processivity of multiubiquitination by the APC determines the order of substrate degradation.Rape M., Reddy S.K., Kirschner M.W.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCCell 124:89-103 (2006)Mapped to72
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.Tachibana M., Ueda J., Fukuda M., Takeda N., Ohta T., Iwanari H., Sakihama T., Kodama T., Hamakubo T., Shinkai Y.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCGenes Dev. 19:815-826 (2005)Cited in21Mapped to43
The anaphase-promoting complex: a key factor in the regulation of cell cycle.Castro A., Bernis C., Vigneron S., Labbe J.C., Lorca T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCOncogene 24:314-325 (2005)Mapped to72
Mammalian Cdh1/Fzr mediates its own degradation.Listovsky T., Oren Y.S., Yudkovsky Y., Mahbubani H.M., Weiss A.M., Lebendiker M., Brandeis M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCEMBO J 23:1619-1626 (2004)Mapped to79
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Wei W., Ayad N.G., Wan Y., Zhang G.J., Kirschner M.W., Kaelin W.G. Jr.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174141PubMedEurope PMCNature 428:194-198 (2004)Mapped to68
U-box proteins as a new family of ubiquitin ligases.Hatakeyama S., Nakayama K.I.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCBiochem Biophys Res Commun 302:635-645 (2003)Mapped to99+
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.Hagting A., Den Elzen N., Vodermaier H.C., Waizenegger I.C., Peters J.M., Pines J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCJ Cell Biol 157:1125-1137 (2002)Mapped to68
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.Geley S., Kramer E., Gieffers C., Gannon J., Peters J.M., Hunt T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-174229PubMedEurope PMCJ Cell Biol 153:137-148 (2001)Mapped to74