Q9UJA5 · TRM6_HUMAN

  • Protein
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
  • Gene
    TRMT6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508).
Together with the TRMT61A catalytic subunit, part of a mRNA N1-methyltransferase complex that mediates methylation of adenosine residues at the N1 position of a small subset of mRNAs: N1 methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537).

Features

Showing features for binding site.

149750100150200250300350400450
TypeIDPosition(s)Description
Binding site94-104substrate
Binding site145-154substrate
Binding site175-182substrate
Binding site349substrate
Binding site377substrate
Binding site415-423substrate
Binding site434-441substrate

GO annotations

AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponenttRNA (m1A) methyltransferase complex
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological ProcesstRNA methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
  • Alternative names
    • mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6
    • tRNA(m1A58)-methyltransferase subunit TRM6 (tRNA(m1A58)MTase subunit TRM6)

Gene names

    • Name
      TRMT6
    • Synonyms
      KIAA1153, TRM6
    • ORF names
      CGI-09

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9UJA5
  • Secondary accessions
    • B4DUV6
    • Q76P92
    • Q9BQV5
    • Q9ULR7
    • Q9Y2Z8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_053789293in dbSNP:rs6139876
Natural variantVAR_053790299in dbSNP:rs451571
Natural variantVAR_053791333in dbSNP:rs35203742

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 513 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002330981-497UniProttRNA (adenine58-N1)-methyltransferase non-catalytic subunit TRM6
Modified residue107UniProtPhosphothreonine
Modified residue (large scale data)288PRIDEPhosphoserine
Modified residue (large scale data)291PRIDEPhosphothreonine
Modified residue298UniProtPhosphoserine
Modified residue305UniProtPhosphoserine
Modified residue (large scale data)475PRIDEPhosphoserine
Modified residue (large scale data)476PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain, liver, testis and ovary.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.

Binary interactions

View interactors in UniProtKB
View CPX-6269 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-20Disordered
Region69-100Disordered
Compositional bias74-100Basic and acidic residues
Region276-354Disordered
Compositional bias292-354Basic and acidic residues
Region472-497Disordered
Compositional bias477-497Basic and acidic residues

Sequence similarities

Belongs to the TRM6/GCD10 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9UJA5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    497
  • Mass (Da)
    55,799
  • Last updated
    2000-05-01 v1
  • Checksum
    920800D0722A6CBB
MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGHSYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAKMLSSEPKDSALVEESNGTLEEKQASEQENEDSMAEAPESNHPEDQETMETISQDPEHKGPKERGSKKDYIQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESHETEEPAAKKRKCPESDS

Q9UJA5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 372-497: LIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESHETEEPAAKKRKCPESDS → CVDGRRQETPQCMWALLQTDWHSLSPCL

Q9UJA5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 344-365: QEKQRRQEEQRKRHLEAAALLS → SGKNRGRQGRSSGKDFWGCRFA
    • 366-497: Missing

Q9UJA5-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence BAA86467.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence BAA86467.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0547401-170in isoform 4
Compositional bias74-100Basic and acidic residues
Compositional bias292-354Basic and acidic residues
Alternative sequenceVSP_031100344-365in isoform 3
Alternative sequenceVSP_031101366-497in isoform 3
Alternative sequenceVSP_018025372-497in isoform 2
Compositional bias477-497Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB032979
EMBL· GenBank· DDBJ
BAA86467.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AF132943
EMBL· GenBank· DDBJ
AAD27718.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK000613
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK300812
EMBL· GenBank· DDBJ
BAG62468.1
EMBL· GenBank· DDBJ
mRNA
AL035461
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC001262
EMBL· GenBank· DDBJ
AAH01262.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp