Q9UGM5 · FETUB_HUMAN

  • Protein
    Fetuin-B
  • Gene
    FETUB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular exosome
Cellular Componentextracellular region
Molecular Functioncysteine-type endopeptidase inhibitor activity
Molecular Functionmetalloendopeptidase inhibitor activity
Biological Processbinding of sperm to zona pellucida
Biological Processnegative regulation of endopeptidase activity
Biological Processsingle fertilization

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Fetuin-B
  • Alternative names
    • 16G2
    • Fetuin-like protein IRL685
    • Gugu

Gene names

    • Name
      FETUB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9UGM5
  • Secondary accessions
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04906133in dbSNP:rs34522046
Natural variantVAR_024449202in dbSNP:rs6785067
Natural variantVAR_049062360in dbSNP:rs7999

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 554 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Signal1-15UniProt
ChainPRO_000000889916-382UniProtFetuin-B
Glycosylation37UniProtN-linked (GlcNAc...) asparagine
Disulfide bond93↔104UniProt
Disulfide bond117↔137UniProt
Glycosylation136UniProtN-linked (GlcNAc...) asparagine
Disulfide bond151↔154UniProt
Glycosylation182UniProtN-linked (GlcNAc...) asparagine
Disulfide bond216↔224UniProt
Disulfide bond237↔254UniProt
Glycosylation289UniProtO-linked (GalNAc...) threonine
Glycosylation292UniProtO-linked (GalNAc...) threonine
Modified residue315UniProtPhosphoserine
Modified residue (large scale data)315PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Liver and testis.

Developmental stage

2-fold increase toward the end of the menstrual cycle.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain25-138Cystatin fetuin-B-type 1
Domain149-255Cystatin fetuin-B-type 2
Compositional bias262-299Polar residues
Region262-320Disordered
Region363-382Disordered

Sequence similarities

Belongs to the fetuin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q9UGM5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    382
  • Mass (Da)
    42,055
  • Last updated
    2006-06-27 v2
  • Checksum
    C73977793A30AF8A
MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNASPLVLPP

Q9UGM5-2

  • Name
    2
  • Synonyms
    Beta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WEP7F8WEP7_HUMANFETUB119
F8WAW1F8WAW1_HUMANFETUB92
C9JC68C9JC68_HUMANFETUB103
E9PG08E9PG08_HUMANFETUB317

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict4in Ref. 2; AAR22507
Sequence conflict9in Ref. 7; AAH74734
Sequence conflict18-19in Ref. 1; CAB62538
Alternative sequenceVSP_04713576-112in isoform 2
Sequence conflict179in Ref. 7; AAH74734
Compositional bias262-299Polar residues
Sequence conflict303in Ref. 7; AAI14617

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ242928
EMBL· GenBank· DDBJ
CAB62538.1
EMBL· GenBank· DDBJ
mRNA
AF534529
EMBL· GenBank· DDBJ
AAQ10515.1
EMBL· GenBank· DDBJ
mRNA
AY373820
EMBL· GenBank· DDBJ
AAR22507.1
EMBL· GenBank· DDBJ
mRNA
AB017551
EMBL· GenBank· DDBJ
BAA78341.1
EMBL· GenBank· DDBJ
mRNA
AK315309
EMBL· GenBank· DDBJ
BAG37713.1
EMBL· GenBank· DDBJ
mRNA
AC068631
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471052
EMBL· GenBank· DDBJ
EAW78186.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069670
EMBL· GenBank· DDBJ
AAH69670.1
EMBL· GenBank· DDBJ
mRNA
BC069820
EMBL· GenBank· DDBJ
AAH69820.1
EMBL· GenBank· DDBJ
mRNA
BC074734
EMBL· GenBank· DDBJ
AAH74734.1
EMBL· GenBank· DDBJ
mRNA
BC114616
EMBL· GenBank· DDBJ
AAI14617.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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