Q9UGK3 · STAP2_HUMAN
- ProteinSignal-transducing adaptor protein 2
- GeneSTAP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids403 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | signaling adaptor activity |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSignal-transducing adaptor protein 2
- Short namesSTAP-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UGK3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 22 | Small decrease in tyrosine phosphorylation. | ||||
Sequence: Y → F | ||||||
Natural variant | VAR_055239 | 93 | in dbSNP:rs7247504 | |||
Sequence: D → N | ||||||
Mutagenesis | 250 | Loss of tyrosine phosphorylation. | ||||
Sequence: Y → F | ||||||
Mutagenesis | 310 | Decrease in tyrosine phosphorylation. | ||||
Sequence: Y → F | ||||||
Mutagenesis | 322 | Decrease in tyrosine phosphorylation. | ||||
Sequence: Y → F |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 535 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000072239 | 1-403 | UniProt | Signal-transducing adaptor protein 2 | |||
Sequence: MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHVEKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELRVPTDLTLLPGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKALVPFLLDEDYEKVLGYVEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASSQDKLPPLPPLPNQEENYVTPIGDGPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPKVFNGGLGRKLPVSSAQPLFPTAGLADMTAELQKKLEKRRALEH | |||||||
Modified residue | 22 | UniProt | Phosphotyrosine; by SRC | ||||
Sequence: Y | |||||||
Modified residue | 250 | UniProt | Phosphotyrosine; by PTK6 | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 250 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 289 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 293 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 310 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 322 | UniProt | Phosphotyrosine; by SRC | ||||
Sequence: Y |
Post-translational modification
Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with PTK6 and CSF1R.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9UGK3 | BLK P51451 | 3 | EBI-1553984, EBI-2105445 | |
BINARY | Q9UGK3 | IKBKB O14920 | 7 | EBI-1553984, EBI-81266 | |
BINARY | Q9UGK3 | KEAP1 Q14145 | 3 | EBI-1553984, EBI-751001 | |
BINARY | Q9UGK3 | MYD88 Q99836 | 3 | EBI-1553984, EBI-447677 | |
BINARY | Q9UGK3 | PADI1 Q9ULC6 | 2 | EBI-1553984, EBI-10827384 | |
BINARY | Q9UGK3 | TXK P42681 | 3 | EBI-1553984, EBI-7877438 | |
BINARY | Q9UGK3 | YES1 P07947 | 3 | EBI-1553984, EBI-515331 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-130 | PH | ||||
Sequence: PSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHVEKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELRVPTDLTLLPG | ||||||
Domain | 133-248 | SH2 | ||||
Sequence: YMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKALVPFLLDE | ||||||
Region | 270-308 | Disordered | ||||
Sequence: APSAPGPGPAPCTGGPKPLSPASSQDKLPPLPPLPNQEE | ||||||
Compositional bias | 292-306 | Pro residues | ||||
Sequence: SSQDKLPPLPPLPNQ | ||||||
Region | 331-374 | Disordered | ||||
Sequence: SWPVILKPKKLPKPPAKLPKPPVGPKPEPKVFNGGLGRKLPVSS | ||||||
Compositional bias | 338-358 | Pro residues | ||||
Sequence: PKKLPKPPAKLPKPPVGPKPE | ||||||
Coiled coil | 382-402 | |||||
Sequence: AGLADMTAELQKKLEKRRALE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9UGK3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length403
- Mass (Da)44,894
- Last updated2009-05-05 v2
- ChecksumA5E809B3F233EFD0
Q9UGK3-2
- Name2
- NoteAlu insert from position 358 to 403.
- Differences from canonical
- 356-356: K → KPVEKGFHHVAQAGLELLTSSDPPTSASQSAGITGVSHHTWPHLSSL
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 292-306 | Pro residues | ||||
Sequence: SSQDKLPPLPPLPNQ | ||||||
Compositional bias | 338-358 | Pro residues | ||||
Sequence: PKKLPKPPAKLPKPPVGPKPE | ||||||
Alternative sequence | VSP_041403 | 356 | in isoform 2 | |||
Sequence: K → KPVEKGFHHVAQAGLELLTSSDPPTSASQSAGITGVSHHTWPHLSSL |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ245719 EMBL· GenBank· DDBJ | CAB65105.1 EMBL· GenBank· DDBJ | mRNA | ||
AK000241 EMBL· GenBank· DDBJ | BAA91028.1 EMBL· GenBank· DDBJ | mRNA | ||
AC008616 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC000795 EMBL· GenBank· DDBJ | AAH00795.1 EMBL· GenBank· DDBJ | mRNA |