Q9UDY6 · TRI10_HUMAN
- ProteinTripartite motif-containing protein 10
- GeneTRIM10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids481 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity).
In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).
In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | erythrocyte differentiation | |
Biological Process | innate immune response | |
Biological Process | negative regulation of viral entry into host cell | |
Biological Process | protein ubiquitination |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTripartite motif-containing protein 10
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UDY6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_052127 | 65 | in dbSNP:rs12212092 | |||
Sequence: R → H | ||||||
Natural variant | VAR_052128 | 119 | in dbSNP:rs17194446 | |||
Sequence: V → M |
Variants
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The viewer provides 1,000 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000056211 | 1-481 | Tripartite motif-containing protein 10 | |||
Sequence: MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLSS |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9UDY6 | PSMA1 P25786 | 4 | EBI-6427325, EBI-359352 | |
BINARY | Q9UDY6 | TTC23 Q5W5X9 | 4 | EBI-6427325, EBI-6447954 | |
BINARY | Q9UDY6 | ZNF148 Q9UQR1 | 3 | EBI-6427325, EBI-2688184 | |
BINARY | Q9UDY6-2 | GEM P55040 | 3 | EBI-11981577, EBI-744104 | |
BINARY | Q9UDY6-2 | HGS O14964 | 3 | EBI-11981577, EBI-740220 | |
BINARY | Q9UDY6-2 | LNX1 Q8TBB1 | 3 | EBI-11981577, EBI-739832 | |
BINARY | Q9UDY6-2 | SCNM1 Q9BWG6 | 3 | EBI-11981577, EBI-748391 | |
BINARY | Q9UDY6-2 | TRIM35 Q9UPQ4-2 | 3 | EBI-11981577, EBI-17716262 | |
BINARY | Q9UDY6-2 | TRIM44 Q96DX7 | 4 | EBI-11981577, EBI-8787399 | |
BINARY | Q9UDY6-2 | ZNF414 Q96IQ9 | 3 | EBI-11981577, EBI-744257 | |
BINARY | Q9UDY6-2 | ZNF620 Q6ZNG0 | 3 | EBI-11981577, EBI-4395669 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 16-61 | RING-type | ||||
Sequence: CPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCK | ||||||
Zinc finger | 94-135 | B box-type | ||||
Sequence: GEEDVCQEHGEKIYFFCEDDEMQLCVVCREAGEHATHTMRFL | ||||||
Coiled coil | 150-177 | |||||
Sequence: LKCLRKEREEIQEIQSRENKRMQVLLTQ | ||||||
Domain | 292-481 | B30.2/SPRY | ||||
Sequence: REMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLSS |
Sequence similarities
Belongs to the TRIM/RBCC family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9UDY6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameAlpha
- Length481
- Mass (Da)55,037
- Last updated2004-07-19 v3
- Checksum49A1A11F391F5F98
Q9UDY6-2
- NameBeta
- Differences from canonical
- 369-481: VSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 104 | in Ref. 1; CAB52384 | ||||
Sequence: E → G | ||||||
Sequence conflict | 104 | in Ref. 2; AAG53495/AAG53496 | ||||
Sequence: E → SR | ||||||
Sequence conflict | 167 | in Ref. 2; AAG53495/AAG53496 | ||||
Sequence: E → K | ||||||
Sequence conflict | 336 | in Ref. 1; CAB52384 and 2; AAG53495 | ||||
Sequence: Y → S | ||||||
Alternative sequence | VSP_005748 | 369-481 | in isoform Beta | |||
Sequence: VSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLSS → WMARVPGDSGCCQFCSPPSVLGTEVAA | ||||||
Sequence conflict | 377 | in Ref. 1; CAB52384 and 2; AAG53495 | ||||
Sequence: G → A | ||||||
Sequence conflict | 379 | In isoform Q9UDY6-2; in Ref. 2; AAG53496 | ||||
Sequence: C → G |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y07829 EMBL· GenBank· DDBJ | CAB52384.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF220122 EMBL· GenBank· DDBJ | AAG53495.1 EMBL· GenBank· DDBJ | mRNA | ||
AF220123 EMBL· GenBank· DDBJ | AAG53496.1 EMBL· GenBank· DDBJ | mRNA | ||
AB202085 EMBL· GenBank· DDBJ | BAE78605.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB103595 EMBL· GenBank· DDBJ | BAF31256.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BA000025 EMBL· GenBank· DDBJ | BAB63332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB088089 EMBL· GenBank· DDBJ | BAC54921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL669914 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL671859 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL844220 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX005441 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX927221 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR753815 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR759838 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR788282 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471081 EMBL· GenBank· DDBJ | EAX03268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471081 EMBL· GenBank· DDBJ | EAX03269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC093926 EMBL· GenBank· DDBJ | AAH93926.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113419 EMBL· GenBank· DDBJ | AAI13420.1 EMBL· GenBank· DDBJ | mRNA |