Q9UBZ9 · REV1_HUMAN
- ProteinDNA repair protein REV1
- GeneREV1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1251 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 357 | dCTP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 423 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 423 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 423-427 | dCTP (UniProtKB | ChEBI) | ||||
Sequence: DMDCF | ||||||
Binding site | 510-516 | dCTP (UniProtKB | ChEBI) | ||||
Sequence: SCSYEAR | ||||||
Binding site | 522 | dCTP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 570 | dCTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 570 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 571 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Site | 770 | Interaction with target DNA | ||||
Sequence: K | ||||||
Site | 783 | Interaction with target DNA | ||||
Sequence: T |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Molecular Function | damaged DNA binding | |
Molecular Function | deoxycytidyl transferase activity | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication | |
Biological Process | error-free translesion synthesis | |
Biological Process | error-prone translesion synthesis | |
Biological Process | response to UV |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA repair protein REV1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UBZ9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_021249 | 138 | in dbSNP:rs3087403 | |||
Sequence: V → M | ||||||
Natural variant | VAR_021250 | 257 | in dbSNP:rs3087386 | |||
Sequence: F → S | ||||||
Natural variant | VAR_029193 | 306 | in dbSNP:rs28382882 | |||
Sequence: N → D | ||||||
Natural variant | VAR_021251 | 373 | in dbSNP:rs3087399 | |||
Sequence: N → S | ||||||
Mutagenesis | 570 | Abolishes transferase activity; when associated with A-571. | ||||
Sequence: D → A | ||||||
Mutagenesis | 571 | Abolishes transferase activity; when associated with A-570. | ||||
Sequence: E → A | ||||||
Natural variant | VAR_029194 | 656 | in dbSNP:rs3087394 | |||
Sequence: M → V | ||||||
Natural variant | VAR_029195 | 660 | in dbSNP:rs3087398 | |||
Sequence: L → W | ||||||
Natural variant | VAR_029196 | 700 | in dbSNP:rs28382941 | |||
Sequence: D → N | ||||||
Natural variant | VAR_029197 | 704 | in dbSNP:rs28382942 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_029199 | 902 | in dbSNP:rs28382961 | |||
Sequence: P → H | ||||||
Natural variant | VAR_029198 | 902 | in dbSNP:rs28382960 | |||
Sequence: P → S | ||||||
Natural variant | VAR_029200 | 921 | in dbSNP:rs3087396 | |||
Sequence: S → I | ||||||
Natural variant | VAR_024436 | 1003 | in dbSNP:rs3087401 | |||
Sequence: A → T | ||||||
Natural variant | VAR_029201 | 1060 | in dbSNP:rs3087388 | |||
Sequence: P → T | ||||||
Natural variant | VAR_029202 | 1074 | in dbSNP:rs3087393 | |||
Sequence: N → K | ||||||
Natural variant | VAR_029203 | 1091 | in dbSNP:rs3087392 | |||
Sequence: N → T | ||||||
Natural variant | VAR_029204 | 1102 | in dbSNP:rs3087400 | |||
Sequence: L → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,211 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000173992 | 1-1251 | UniProt | DNA repair protein REV1 | |||
Sequence: MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSYIPYQLYTKQSSVQKGLSFNPVCRPEDPLPGPSNIAKQLNNRVNHIVKKIETENEVKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIFNGHTPSSNGALKTQDCLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSLSPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHHISMWKCELTEFVNTLQRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAADIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTNLNPSTCPSRPSVQSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPTSPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVCAVQQAESHGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQESNSDAGINLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQRQGENSTHQQSASASVPKNPLLHLKAAVKEKKRNKKKKTIGSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTSGVPGLSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT | |||||||
Modified residue (large scale data) | 254 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 297 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 301 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 901 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1088 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1097 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1108 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9UBZ9 | FAAP20 Q6NZ36 | 2 | EBI-7353917, EBI-2817693 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-131 | BRCT | ||||
Sequence: TSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSYIPYQL | ||||||
Region | 206-236 | Disordered | ||||
Sequence: TSPGRKQNGIPHPRGSTAIFNGHTPSSNGAL | ||||||
Region | 282-342 | Disordered | ||||
Sequence: STRNTDALRNPHRTNSFSLSPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSK | ||||||
Region | 352-362 | Interaction with target DNA | ||||
Sequence: FYSHSRLHHIS | ||||||
Domain | 419-653 | UmuC | ||||
Sequence: IMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAADIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVG | ||||||
Region | 653-656 | Interaction with target DNA | ||||
Sequence: GHSM | ||||||
Region | 709-717 | Interaction with target DNA | ||||
Sequence: RKSVSAEIN | ||||||
Region | 1035-1096 | Disordered | ||||
Sequence: AYDQRQRQGENSTHQQSASASVPKNPLLHLKAAVKEKKRNKKKKTIGSPKRIQSPLNNKLLN | ||||||
Compositional bias | 1039-1057 | Polar residues | ||||
Sequence: RQRQGENSTHQQSASASVP | ||||||
Compositional bias | 1068-1082 | Basic residues | ||||
Sequence: VKEKKRNKKKKTIGS | ||||||
Motif | 1071-1078 | Nuclear localization signal | ||||
Sequence: KKRNKKKK | ||||||
Region | 1119-1147 | Disordered | ||||
Sequence: HEGPPAEKPLEELSASTSGVPGLSSLQSD | ||||||
Region | 1150-1249 | Protein interaction domain; mediates interaction with DNA polymerase zeta | ||||
Sequence: GCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLK |
Domain
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q9UBZ9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsREV1
- Length1,251
- Mass (Da)138,248
- Last updated2000-05-01 v1
- Checksum010E261D537DBA80
Q9UBZ9-2
- Name2
- SynonymsREV1S
- Differences from canonical
- 479-479: Missing
Q9UBZ9-3
- Name3
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_012809 | 1-21 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_012810 | 406-413 | in isoform 3 | |||
Sequence: DMSVLNSP → RYLLKLSS | ||||||
Alternative sequence | VSP_012811 | 414-1251 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_012812 | 479 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 1039-1057 | Polar residues | ||||
Sequence: RQRQGENSTHQQSASASVP | ||||||
Compositional bias | 1068-1082 | Basic residues | ||||
Sequence: VKEKKRNKKKKTIGS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF151538 EMBL· GenBank· DDBJ | AAF06731.1 EMBL· GenBank· DDBJ | mRNA | ||
AF206019 EMBL· GenBank· DDBJ | AAF18986.1 EMBL· GenBank· DDBJ | mRNA | ||
AB047646 EMBL· GenBank· DDBJ | BAB21441.1 EMBL· GenBank· DDBJ | mRNA | ||
AF357886 EMBL· GenBank· DDBJ | AAK43708.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK002087 EMBL· GenBank· DDBJ | BAA92079.1 EMBL· GenBank· DDBJ | mRNA | ||
AC018690 EMBL· GenBank· DDBJ | AAY24314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ131720 EMBL· GenBank· DDBJ | CAB38231.1 EMBL· GenBank· DDBJ | mRNA |