Q9UBY5 · LPAR3_HUMAN
- ProteinLysophosphatidic acid receptor 3
- GeneLPAR3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | lipid binding | |
Molecular Function | lysophosphatidic acid receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | bleb assembly | |
Biological Process | chemical synaptic transmission | |
Biological Process | collateral sprouting | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | gene expression | |
Biological Process | positive regulation of collateral sprouting | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | regulation of metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameLysophosphatidic acid receptor 3
- Short namesLPA receptor 3; LPA-3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9UBY5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Extracellular | ||||
Sequence: MNECHYDKHMDFFYNRSNTDTVDDWTGTKLV | ||||||
Transmembrane | 32-52 | Helical; Name=1 | ||||
Sequence: IVLCVGTFFCLFIFFSNSLVI | ||||||
Topological domain | 53-67 | Cytoplasmic | ||||
Sequence: AAVIKNRKFHFPFYY | ||||||
Transmembrane | 68-88 | Helical; Name=2 | ||||
Sequence: LLANLAAADFFAGIAYVFLMF | ||||||
Topological domain | 89-101 | Extracellular | ||||
Sequence: NTGPVSKTLTVNR | ||||||
Transmembrane | 102-124 | Helical; Name=3 | ||||
Sequence: WFLRQGLLDSSLTASLTNLLVIA | ||||||
Topological domain | 125-146 | Cytoplasmic | ||||
Sequence: VERHMSIMRMRVHSNLTKKRVT | ||||||
Transmembrane | 147-167 | Helical; Name=4 | ||||
Sequence: LLILLVWAIAIFMGAVPTLGW | ||||||
Topological domain | 168-186 | Extracellular | ||||
Sequence: NCLCNISACSSLAPIYSRS | ||||||
Transmembrane | 187-207 | Helical; Name=5 | ||||
Sequence: YLVFWTVSNLMAFLIMVVVYL | ||||||
Topological domain | 208-240 | Cytoplasmic | ||||
Sequence: RIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKT | ||||||
Transmembrane | 241-261 | Helical; Name=6 | ||||
Sequence: VMTVLGAFVVCWTPGLVVLLL | ||||||
Topological domain | 262-276 | Extracellular | ||||
Sequence: DGLNCRQCGVQHVKR | ||||||
Transmembrane | 277-297 | Helical; Name=7 | ||||
Sequence: WFLLLALLNSVVNPIIYSYKD | ||||||
Topological domain | 298-353 | Cytoplasmic | ||||
Sequence: EDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_049415 | 231 | in dbSNP:rs35745543 | |||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 462 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, lipidation, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000069433 | 1-353 | UniProt | Lysophosphatidic acid receptor 3 | |||
Sequence: MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS | |||||||
Glycosylation | 15 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 172 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Lipidation | 309 | UniProt | S-palmitoyl cysteine | ||||
Sequence: C | |||||||
Modified residue (large scale data) | 325 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 333 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,128
- Last updated2000-05-01 v1
- Checksum105DC9DD185E2CE7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF127138 EMBL· GenBank· DDBJ | AAD56311.1 EMBL· GenBank· DDBJ | mRNA | ||
AF186380 EMBL· GenBank· DDBJ | AAF00530.1 EMBL· GenBank· DDBJ | mRNA | ||
AY322547 EMBL· GenBank· DDBJ | AAP84360.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126268 EMBL· GenBank· DDBJ | AAI26269.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126270 EMBL· GenBank· DDBJ | AAI26271.1 EMBL· GenBank· DDBJ | mRNA |