Q9U4F3 · SURF1_DROME
- ProteinSURF1-like protein
- GeneSurf1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids300 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Probably involved in the biogenesis of the COX complex.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Biological Process | instar larval development | |
Biological Process | mitochondrial cytochrome c oxidase assembly | |
Biological Process | mitochondrial respirasome assembly | |
Biological Process | phototaxis | |
Biological Process | visual behavior |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSURF1-like protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9U4F3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-82 | Helical | ||||
Sequence: IAPLGWFLLLIPATTFGLGCWQV | ||||||
Transmembrane | 271-291 | Helical | ||||
Sequence: DHLSYLVTWFSLSAATSFLWY |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Lethal at larval stage (PubMed:16172499).
Larvae show reduced locomotor speed and response to light (PubMed:16172499).
Results in smaller muscle fibers with mitochondria defects (PubMed:16172499).
RNAi-mediated knockdown is lethal at larval stage (PubMed:25164807).
RNAi-mediated knockdown in the developing CNS, in the eye and antenna disk from early larval stages shows increased lifespan with reduction of COX activity, increased succinate dehydrogenase (SDH) activity, reduced locomotor speed and response to light (PubMed:16172499, PubMed:25164807).
RNAi-mediated knockdown in mesodermal derivatives from early embryonic stages to pupal metamorphosis is lethal at pupal stage with muscles showing enlarged and disorganized mitochondria and reduced activity of all mitochondrial respiratory chain complexes (PubMed:25164807).
Larvae show reduced locomotor speed and response to light (PubMed:16172499).
Results in smaller muscle fibers with mitochondria defects (PubMed:16172499).
RNAi-mediated knockdown is lethal at larval stage (PubMed:25164807).
RNAi-mediated knockdown in the developing CNS, in the eye and antenna disk from early larval stages shows increased lifespan with reduction of COX activity, increased succinate dehydrogenase (SDH) activity, reduced locomotor speed and response to light (PubMed:16172499, PubMed:25164807).
RNAi-mediated knockdown in mesodermal derivatives from early embryonic stages to pupal metamorphosis is lethal at pupal stage with muscles showing enlarged and disorganized mitochondria and reduced activity of all mitochondrial respiratory chain complexes (PubMed:25164807).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000215657 | 1-300 | SURF1-like protein | |||
Sequence: MIRLGNQMCRQVAFNIQTVFRNPGTANNPRLITRKMTQQRPPVNWTTSIPNQAAKDKEKIAPLGWFLLLIPATTFGLGCWQVKRKIWKEQLIKDLNKQLSTAPVALPDDLTDLAQMEYRLVKIRGRFLHDKEMRLGPRSLIRPDGVETQGGLFSQRDSGNGYLIVTPFQLADRDDIVLVNRGWVSRKQVEPETRPLGQQQAEVELTAVVRKGEARPQFTPDHKGNVYLYRDLARMCAATGAAPVFLDAVYDPQTAAHAPIGGQTRVTLRNDHLSYLVTWFSLSAATSFLWYRQIVKRIPF |
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)34,064
- Last updated2000-05-01 v1
- Checksum59C6969FA0E9A9C1
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF182954 EMBL· GenBank· DDBJ | AAF19610.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50632.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY118815 EMBL· GenBank· DDBJ | AAM50675.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |