Q9U4F3 · SURF1_DROME

Function

function

Probably involved in the biogenesis of the COX complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Biological Processinstar larval development
Biological Processmitochondrial cytochrome c oxidase assembly
Biological Processmitochondrial respirasome assembly
Biological Processphototaxis
Biological Processvisual behavior

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SURF1-like protein

Gene names

    • Name
      Surf1
    • ORF names
      CG9943

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9U4F3
  • Secondary accessions
    • Q8MSH4
    • Q9VRZ8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-82Helical
Transmembrane271-291Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Lethal at larval stage (PubMed:16172499).
Larvae show reduced locomotor speed and response to light (PubMed:16172499).
Results in smaller muscle fibers with mitochondria defects (PubMed:16172499).
RNAi-mediated knockdown is lethal at larval stage (PubMed:25164807).
RNAi-mediated knockdown in the developing CNS, in the eye and antenna disk from early larval stages shows increased lifespan with reduction of COX activity, increased succinate dehydrogenase (SDH) activity, reduced locomotor speed and response to light (PubMed:16172499, PubMed:25164807).
RNAi-mediated knockdown in mesodermal derivatives from early embryonic stages to pupal metamorphosis is lethal at pupal stage with muscles showing enlarged and disorganized mitochondria and reduced activity of all mitochondrial respiratory chain complexes (PubMed:25164807).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002156571-300SURF1-like protein

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the SURF1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    300
  • Mass (Da)
    34,064
  • Last updated
    2000-05-01 v1
  • Checksum
    59C6969FA0E9A9C1
MIRLGNQMCRQVAFNIQTVFRNPGTANNPRLITRKMTQQRPPVNWTTSIPNQAAKDKEKIAPLGWFLLLIPATTFGLGCWQVKRKIWKEQLIKDLNKQLSTAPVALPDDLTDLAQMEYRLVKIRGRFLHDKEMRLGPRSLIRPDGVETQGGLFSQRDSGNGYLIVTPFQLADRDDIVLVNRGWVSRKQVEPETRPLGQQQAEVELTAVVRKGEARPQFTPDHKGNVYLYRDLARMCAATGAAPVFLDAVYDPQTAAHAPIGGQTRVTLRNDHLSYLVTWFSLSAATSFLWYRQIVKRIPF

Sequence caution

The sequence AAM50675.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF182954
EMBL· GenBank· DDBJ
AAF19610.1
EMBL· GenBank· DDBJ
mRNA
AE014296
EMBL· GenBank· DDBJ
AAF50632.2
EMBL· GenBank· DDBJ
Genomic DNA
AY118815
EMBL· GenBank· DDBJ
AAM50675.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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