Q9U1Y5 · CHK2_CAEEL
- ProteinSerine/threonine-protein kinase chk-2
- Genechk-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 177-184 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GKGGFGKV | ||||||
Binding site | 199 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 252-258 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYVGGGE | ||||||
Active site | 301 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 305-306 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EN | ||||||
Binding site | 322 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cell division | |
Biological Process | DNA repair | |
Biological Process | mitotic DNA damage checkpoint signaling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase chk-2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9U1Y5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085860 | 1-476 | Serine/threonine-protein kinase chk-2 | |||
Sequence: MVRGTKRRRSSAEKPIVVVPVTRDDTMPVDEDLVVGESQCAASKPFAKLVGVRRGISSIDLADDHFVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPALIIFVYESADADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWMKCADCRTAKQDILKSIKPISAAAPAALQTTQAGPVKKAKM |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Highly expressed in germline tissue.
Developmental stage
Low expression in embryos and L2 larvae, high expression in hermaphrodite adults.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 66-127 | FHA | ||||
Sequence: FVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHSRNGTLVNQEMI | ||||||
Domain | 170-436 | Protein kinase | ||||
Sequence: HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWM |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)53,338
- Last updated2001-10-01 v2
- Checksum9762018F599F9A7B
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 10-13 | in Ref. 3; BAB15803 | ||||
Sequence: SSAE → ARRK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB041996 EMBL· GenBank· DDBJ | BAB20578.1 EMBL· GenBank· DDBJ | mRNA | ||
AL117207 EMBL· GenBank· DDBJ | CAB60407.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB049441 EMBL· GenBank· DDBJ | BAB15803.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |