Q9U1M8 · MYOI_DICDI

Function

function

Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.

Features

Showing features for binding site.

123572004006008001,0001,2001,4001,6001,8002,0002,200
TypeIDPosition(s)Description
Binding site106-113ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentcell cortex
Cellular Componentcell leading edge
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentfilopodium
Cellular Componentfilopodium tip
Cellular Componentmembrane
Cellular Componentmyosin complex
Cellular Componentphagocytic cup
Molecular Functionactin binding
Molecular Functionactin filament binding
Molecular FunctionATP binding
Molecular Functioncytoskeletal motor activity
Molecular Functionmicrofilament motor activity
Molecular Functionmicrotubule binding
Biological Processactin filament organization
Biological Processactin filament-based movement
Biological Processcell morphogenesis
Biological Processcell-substrate adhesion
Biological Processendocytosis
Biological Processfilopodium assembly
Biological Processphagocytosis
Biological Processspore germination

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myosin-I heavy chain
  • Alternative names
    • Class VII unconventional myosin
    • DdMVII (DdM7)

Gene names

    • Name
      myoI
    • ORF names
      DDB_G0274455

Organism names

Accessions

  • Primary accession
    Q9U1M8
  • Secondary accessions
    • P90536
    • Q555A2
    • Q869S1

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003286061-2357Myosin-I heavy chain

Proteomic databases

Interaction

Subunit

Monomer. Interacts with talA.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

Type
IDPosition(s)Description
Domain13-688Myosin motor
Region579-586Actin-binding
Domain691-720IQ
Coiled coil787-891
Region787-1076Binding to talin A
Region797-852Disordered
Region974-1112Disordered
Compositional bias1003-1032Polar residues
Compositional bias1033-1049Pro residues
Compositional bias1081-1112Polar residues
Domain1155-1313MyTH4 1
Domain1318-1620FERM 1
Domain1618-1678SH3
Compositional bias1686-1737Pro residues
Region1686-1849Disordered
Compositional bias1744-1758Pro residues
Compositional bias1790-1815Pro residues
Compositional bias1816-1849Polar residues
Domain1894-2051MyTH4 2
Domain2060-2357FERM 2

Domain

The coiled-coil and the proline-rich region are responsible to the binding to talA.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,357
  • Mass (Da)
    268,284
  • Last updated
    2000-05-01 v1
  • Checksum
    FC667F12F207B0C2
MEDDDTLNGEYFQPVEDMITLPILTEESLLLNLKMRYKKKEIYTYTGSILVAVNPYEILPIYTADIVKSYFAKSRNLMLPHIFAVSDAAFTNMIEEGKNQSIIISGESGAGKTESTKLIIQYLAARTNRHSQVEQMIVESSPILEAFGNAKTIRNNNSSRFGKFIEIQFNREGHISGARIINYLLEKSRISHQASSERNYHIFYQLLAGASDELKEKLKLGEPEDYHYLSQSGCIRIENINDVEDFEHVKYAMNVLGLPEDKQFTIFSIVSAVLHIGNLKFEKSEKTQGAEGSEVSNKDTLKIIAQLLSVDPVKLETCLTIRHVLIRGQNFVIPLKVNEAEDTRDSLAKALYGNVFNWLVVFINSKIHKPQKNSTFIGVLDIFGFENFKKNSFEQFCINFANEKLQQHFNQHIFKLEQEEYEKEKINWSKIVYNDNQECLDLIEKRPLGILSLLDEESRFPQATDLTYLDKLHTNHEKHPYYEKPRRSKNTFVVKHYAGEVHYDTQGFLDKNKDTVSDDLSSLLQGSKSKFIIELFTPPREEGDDSDKGREKKKTTAGQTFKTQLQSLINILSSTQPHYVRCIKPNTTKEPAVYDRELIQAQLRYAGMMETIRIRKLGYPIRHTHKEFRDRYLILDYRARSTDHKQTCAGLINLLSGTGGLERDEWQLGNTKVFIRDHQYLKLEELRKLKLLKKVTLIQSVWRMYRCKKRYQQIRASAKILGAAMLSHSSRRDFQEQRQAVQRIKGFFKMLTYQKQFKIIQINLRIVQNNIRSFIARRHSRNAVLLKRDRNARMLEIQREKDEEERNRQEKEERDRQEKEDKEKETADRRQLQEEQKRREEELRAKREEEELKKLEEKKSQLKELNQIDELSSLERMLKEQQDKNINELDDFVNSLEAFSFEGGVDDSQPYSFNHKMYEMSPEALDKISITDLLQGLKQTVRSVTKFEVDESKFELPPGIENVLKRAPGIKRQASSFLPGQPIPDVYSSPQYPVDEADDDDSNNNYINSNNGDLPLPTSQSSDFSLPPPPSSSSMDFGLPPPPPSSSSGGTYSLPPMPVFDFGMIDPILGAPPPPPSTSDSTSPSATATGNNTPNSSSASASQSTNQVNPQPTVSVVELPQILNDEEISLYSFYDYANKNFNIEKLKQKDDIFSYQKSHIKSSLLVHSDAEQTKVAVEIFSKVLHYMNSNPLVSKKDPADFYSPVKFILTKGLAIESLRDEIYCQLIKQSTSNPIQDLNIRVWELIHFTCSTFPPTRKLIKYFAAYLKTTIQQSDVSKSVKDSAQASYFILQRFTLNGARKQVPSVTELESIKENRPIFVRITATDGSLKGLHIDSATTCQESSNDLSQRSRMRVNSKENGFTIIESFNGIERDIAPTDKLCDVLSKVENLQATLSSKIQVNFKFVFKKKLFFDNITNNVPTTSINVENEFYYHQLFNDLFNSNYCKDQDYQISIGSLKLQFESSDYTDEIRAWLPGNGRGKYFTTDIEKNRFDDFINKYKSHKGLSPEDAKKQMVQLLEKHPLANCSLVVCEHQSESLPYPKNFVLALNVNGINIYDPATSKMLESVKYSNQSQQNLKSDDKSVSIILENKSTLQAFTGDVQKLVSLIKEYSLYLRNNAKYARALKDYNVSDTSLLPFKRNDIITITFKDQENKWFMGQLNGKEGSFPVDHVEILLSDVPPPQPVHPVATLSPPMSPTIPNITNTPPPPPSISDSMSPPPQVGMLPPPPPPSVMGSTKPIEIPSLGIPPPPPSSSNSSVPNSPIGSPMMGIPPPPPTISVHSLSNSGNSTPPPPLPSLSTPPTLSTPPPISSPPNFRSSLRVSMLNTSNDGGDNSSDDPSKRLTVSPAIGTDSQLAQWASTRFRSFKRASTLNQQQATLKRKAPVDPNTAFYFNKDPIKESLIEMEAKLSKKAIKNFSEIMMWMGDYPIPKGQTASLVIQSIISRGIENHELRDEIYCQAYRQTNKNPKVESAKKGFELIYFLSITFSPSDSLLQPFMEQLMSRNIAIQSSSPQLASLIAVCIEKLESHPIPSYQQRKMGPSATEIQSFRSNLENGDISTCKIRFIDQSTKLAKINTYTTIREITDTVCRQYGISQQSIKMFGISAVNETAGISKVVSETDMIYDVLARWEQSEEKGEFYFQVRRRFFLDDVNKILDQEHLWTDDDICFELTYCQIRDEWMKGLYTNVNEKDSSIIAAILIQLLYPNQSKLVLTKEVVRQVLPDQILNSQNIKVWISMIESQIFELVSQTPEYLKLMFINLIGSKSPLFGCTLFNIQQKENPPKAWLAINKKGVSIFDPHTKESKNFWTFQSISNVAFTDDTFCIMTGNLMKPIKQTFTTDEHSSIASVYQFYSSQ

Sequence caution

The sequence AAB40932.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1003-1032Polar residues
Compositional bias1033-1049Pro residues
Compositional bias1081-1112Polar residues
Compositional bias1686-1737Pro residues
Compositional bias1744-1758Pro residues
Compositional bias1790-1815Pro residues
Compositional bias1816-1849Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L35321
EMBL· GenBank· DDBJ
AAF06035.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000012
EMBL· GenBank· DDBJ
EAL70120.1
EMBL· GenBank· DDBJ
Genomic DNA
U83089
EMBL· GenBank· DDBJ
AAB40932.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

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