Q9U1M8 · MYOI_DICDI
- ProteinMyosin-I heavy chain
- GenemyoI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2357 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 106-113 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cell cortex | |
Cellular Component | cell leading edge | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | filopodium | |
Cellular Component | filopodium tip | |
Cellular Component | membrane | |
Cellular Component | myosin complex | |
Cellular Component | phagocytic cup | |
Molecular Function | actin binding | |
Molecular Function | actin filament binding | |
Molecular Function | ATP binding | |
Molecular Function | cytoskeletal motor activity | |
Molecular Function | microfilament motor activity | |
Molecular Function | microtubule binding | |
Biological Process | actin filament organization | |
Biological Process | actin filament-based movement | |
Biological Process | cell morphogenesis | |
Biological Process | cell-substrate adhesion | |
Biological Process | endocytosis | |
Biological Process | filopodium assembly | |
Biological Process | phagocytosis | |
Biological Process | spore germination |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyosin-I heavy chain
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ9U1M8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000328606 | 1-2357 | Myosin-I heavy chain | ||
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-688 | Myosin motor | |||
Region | 579-586 | Actin-binding | |||
Domain | 691-720 | IQ | |||
Coiled coil | 787-891 | ||||
Region | 787-1076 | Binding to talin A | |||
Region | 797-852 | Disordered | |||
Region | 974-1112 | Disordered | |||
Compositional bias | 1003-1032 | Polar residues | |||
Compositional bias | 1033-1049 | Pro residues | |||
Compositional bias | 1081-1112 | Polar residues | |||
Domain | 1155-1313 | MyTH4 1 | |||
Domain | 1318-1620 | FERM 1 | |||
Domain | 1618-1678 | SH3 | |||
Compositional bias | 1686-1737 | Pro residues | |||
Region | 1686-1849 | Disordered | |||
Compositional bias | 1744-1758 | Pro residues | |||
Compositional bias | 1790-1815 | Pro residues | |||
Compositional bias | 1816-1849 | Polar residues | |||
Domain | 1894-2051 | MyTH4 2 | |||
Domain | 2060-2357 | FERM 2 | |||
Domain
The coiled-coil and the proline-rich region are responsible to the binding to talA.
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,357
- Mass (Da)268,284
- Last updated2000-05-01 v1
- ChecksumFC667F12F207B0C2
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1003-1032 | Polar residues | |||
Compositional bias | 1033-1049 | Pro residues | |||
Compositional bias | 1081-1112 | Polar residues | |||
Compositional bias | 1686-1737 | Pro residues | |||
Compositional bias | 1744-1758 | Pro residues | |||
Compositional bias | 1790-1815 | Pro residues | |||
Compositional bias | 1816-1849 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L35321 EMBL· GenBank· DDBJ | AAF06035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAFI02000012 EMBL· GenBank· DDBJ | EAL70120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U83089 EMBL· GenBank· DDBJ | AAB40932.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |