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Q9TYV2 · SMSR2_CAEEL

  • Protein
    Sphingomyelin synthase-related 2
  • Gene
    sms-5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Features

Showing features for active site.

132750100150200250300
TypeIDPosition(s)Description
Active site201
Active site244
Active site248

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionceramide cholinephosphotransferase activity
Molecular Functionsphingomyelin synthase activity
Biological Processceramide biosynthetic process
Biological Processsphingomyelin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin synthase-related 2
  • EC number

Gene names

    • Name
      sms-5
    • ORF names
      W07E6.3

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9TYV2
  • Secondary accessions
    • U4PB50
    • U4PED8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane, topological domain.

Type
IDPosition(s)Description
Transmembrane54-74Helical
Transmembrane99-119Helical
Transmembrane131-151Helical
Transmembrane192-212Helical
Transmembrane220-240Helical
Topological domain241-327Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002210781-327Sphingomyelin synthase-related 2

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the sphingomyelin synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9TYV2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    327
  • Mass (Da)
    37,849
  • Last updated
    2018-04-25 v2
  • MD5 Checksum
    CBFA5B9A3F1E0DB71FACCC745ED73412
MKKDAENENLLHAYEHDEQSSKYFIKPDSRYSIDDDISVKIDGKQLEVRKWPTLLATAMVGVGWLSNEVALAWVHERVPDDYHPLPDLFFSHFPEIRGAIRIAEYIMMILLISALLVMFTHQHRWIVIRRVFFCIAMAYSFRALCVTIFQVPVPSINTYCAPKSNSSLELVAGRVVKMFWSAGIEQLRPRELCGDLIVSGHTLTIFTAFLVFKTYAPQRLQPLSHIYHVLAFTALFSILLARKHYMIDIVLGYTVSTRIFMEYHALAASYHNRTFETNPLAWSFWSFFIPIFECDAPANMHNHLLLYNRSTSSKNVSTLKKSRRSFE

Q9TYV2-3

  • Name
    c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0595581-106in isoform c

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CDH93085.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284602
EMBL· GenBank· DDBJ
CDH93086.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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