Q9TXV7 · TYDP1_CAEEL
- ProteinProbable tyrosyl-DNA phosphodiesterase
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids451 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
Features
Showing features for active site, binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 131 | Nucleophile | ||||
Sequence: H | ||||||
Binding site | 133 | substrate | ||||
Sequence: K | ||||||
Active site | 356 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 358 | substrate | ||||
Sequence: K | ||||||
Site | 379 | Interaction with DNA | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 3'-tyrosyl-DNA phosphodiesterase activity | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | exonuclease activity | |
Molecular Function | single-stranded DNA binding | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable tyrosyl-DNA phosphodiesterase
- EC number
- Short namesTyr-DNA phosphodiesterase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9TXV7
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000212488 | 1-451 | Probable tyrosyl-DNA phosphodiesterase | |||
Sequence: MKRTIQETPGPSSTTVPPPKKLNSQRNGSNLEPGSIYFTPIGGISVPRQESESSRSLDEILADIRPINSLHFSFMLDFEFLIGSYPPSLREYPITLVVGAPDAPDLLKCTKNQKLVTVVGASLPIPFGTHHTKMSILEDEDGRFHVIVSTANLVPDDWEFKTQQFYYNFGVKIASGTVPRSDFQDDLLEYLSMYRNQLDTWKQLLQKVDFSQISDRLIFSTPGYHTDPPTQRPGHPRLFRILSEKFPFDASYEHTERCTFVAQCSSIGSLGSAPINWFRGQFLQSLEGANPSPKQKPAKMYLVFPSVEDVRTSCQGYAGGCSVPYRNSVHARQKWLQGNMCKWRSNAKRRTNAVPHCKTYVKYDKKVAIWQLLTSANLSKAAWGEVSFNKSKNVEQLMIRSWEMGVLITDPSRFNIPFDYPLVPYSATDEPFVTDKKHEKPDILGCIWTPP |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MKRTIQETPGPSSTTVPPPKKLNSQRNGSNLEPG | ||||||
Region | 266-269 | Interaction with DNA | ||||
Sequence: SIGS |
Sequence similarities
Belongs to the tyrosyl-DNA phosphodiesterase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length451
- Mass (Da)51,058
- Last updated2000-05-01 v1
- Checksum02C81CB96FC90C2C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO081438 EMBL· GenBank· DDBJ | CCD71624.1 EMBL· GenBank· DDBJ | Genomic DNA |