Q9TXV7 · TYDP1_CAEEL

  • Protein
    Probable tyrosyl-DNA phosphodiesterase
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).

Features

Showing features for active site, binding site, site.

145150100150200250300350400450
TypeIDPosition(s)Description
Active site131Nucleophile
Binding site133substrate
Active site356Proton donor/acceptor
Binding site358substrate
Site379Interaction with DNA

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function3'-tyrosyl-DNA phosphodiesterase activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionexonuclease activity
Molecular Functionsingle-stranded DNA binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable tyrosyl-DNA phosphodiesterase
  • EC number
  • Short names
    Tyr-DNA phosphodiesterase

Gene names

    • ORF names
      F52C12.1

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9TXV7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002124881-451Probable tyrosyl-DNA phosphodiesterase

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-34Disordered
Region266-269Interaction with DNA

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    51,058
  • Last updated
    2000-05-01 v1
  • Checksum
    02C81CB96FC90C2C
MKRTIQETPGPSSTTVPPPKKLNSQRNGSNLEPGSIYFTPIGGISVPRQESESSRSLDEILADIRPINSLHFSFMLDFEFLIGSYPPSLREYPITLVVGAPDAPDLLKCTKNQKLVTVVGASLPIPFGTHHTKMSILEDEDGRFHVIVSTANLVPDDWEFKTQQFYYNFGVKIASGTVPRSDFQDDLLEYLSMYRNQLDTWKQLLQKVDFSQISDRLIFSTPGYHTDPPTQRPGHPRLFRILSEKFPFDASYEHTERCTFVAQCSSIGSLGSAPINWFRGQFLQSLEGANPSPKQKPAKMYLVFPSVEDVRTSCQGYAGGCSVPYRNSVHARQKWLQGNMCKWRSNAKRRTNAVPHCKTYVKYDKKVAIWQLLTSANLSKAAWGEVSFNKSKNVEQLMIRSWEMGVLITDPSRFNIPFDYPLVPYSATDEPFVTDKKHEKPDILGCIWTPP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
U4PEH4U4PEH4_CAEELtdpo-154
U4PRC2U4PRC2_CAEELtdpo-1318

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO081438
EMBL· GenBank· DDBJ
CCD71624.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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