Q9TW45 · PAR1_CAEEL
- ProteinSerine/threonine-protein kinase par-1
- Genepar-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1192 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115).
Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813).
Regulates mes-1 expression during early embryogenesis (PubMed:11003841).
Critical role in postembryonic vulval morphogenesis (PubMed:12490197).
Involved in the establishment of neuronal polarity (PubMed:20023164).
Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813).
Regulates mes-1 expression during early embryogenesis (PubMed:11003841).
Critical role in postembryonic vulval morphogenesis (PubMed:12490197).
Involved in the establishment of neuronal polarity (PubMed:20023164).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cell periphery | |
Cellular Component | cytoplasm | |
Cellular Component | P granule | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | myosin II tail binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | tau-protein kinase activity | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | asymmetric neuroblast division | |
Biological Process | asymmetric protein localization involved in cell fate determination | |
Biological Process | embryonic pattern specification | |
Biological Process | establishment of cell polarity | |
Biological Process | establishment or maintenance of cell polarity | |
Biological Process | intracellular signal transduction | |
Biological Process | microtubule cytoskeleton organization | |
Biological Process | polarity specification of anterior/posterior axis | |
Biological Process | vulval development |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase par-1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ9TW45
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with germ granules (P granules).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000383322 | 1-1192 | Serine/threonine-protein kinase par-1 | |||
Sequence: MSSASVGKKPEHVNTPPGDNQQKSSKENQKSNKDKQSSNQPPGQIPHSTNSGTRKSSGSGLKTANLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRNDQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLGERKSDMDASEITMAQSLLSHSSINVSSSLGQHPAGVITREHVTSSSASGSSASPSRYSRSSATATGASITAGSALASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAGGTVVMSGTRHGGVQMRAQPTSRQATISLLQPPSYKPSSNTTQIAQIPPLFNRNSTATSSAAQPSTGITGTRKIADPKGRIPLNSTAVQGHRTATGAVAANNGGIPSHRDHAQQQQYMNQLTSSTMMSKLINKTPAAGGTAATSSSSSSSATSTAPLQKSGSQISHAPTEPVIREDDDENNSENQNGNVPLIGGVGPQTSPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLTRRDHNRESMTQPVSGRAGTIGASQGQQTAAALAAIREQSGPIAPGAGQVAPSLPIHEGDVKPRSLRFTWSMKTTSSLAPDDMMREIRKVLDANGCDYEQRERYMILCVHGDPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL | ||||||
Modified residue | 325 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Phosphorylated at Thr-325 probably by par-4.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).
Developmental stage
Maternally expressed.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9TW45 | let-99 Q21341 | 2 | EBI-1811687, EBI-1811800 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MSSASVGKKPEHVNTPPGDNQQKSS | ||||||
Region | 1-163 | Disordered | ||||
Sequence: MSSASVGKKPEHVNTPPGDNQQKSSKENQKSNKDKQSSNQPPGQIPHSTNSGTRKSSGSGLKTANLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRNDQ | ||||||
Compositional bias | 34-158 | Polar residues | ||||
Sequence: DKQSSNQPPGQIPHSTNSGTRKSSGSGLKTANLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAA | ||||||
Domain | 170-421 | Protein kinase | ||||
Sequence: YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWM | ||||||
Domain | 440-482 | UBA | ||||
Sequence: QIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLG | ||||||
Region | 522-541 | Disordered | ||||
Sequence: EHVTSSSASGSSASPSRYSR | ||||||
Compositional bias | 558-591 | Polar residues | ||||
Sequence: ASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAAT | ||||||
Region | 558-601 | Disordered | ||||
Sequence: ASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAGGTVVMSG | ||||||
Compositional bias | 648-663 | Polar residues | ||||
Sequence: STATSSAAQPSTGITG | ||||||
Region | 648-673 | Disordered | ||||
Sequence: STATSSAAQPSTGITGTRKIADPKGR | ||||||
Compositional bias | 727-760 | Polar residues | ||||
Sequence: TPAAGGTAATSSSSSSSATSTAPLQKSGSQISHA | ||||||
Region | 727-938 | Disordered | ||||
Sequence: TPAAGGTAATSSSSSSSATSTAPLQKSGSQISHAPTEPVIREDDDENNSENQNGNVPLIGGVGPQTSPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLT | ||||||
Compositional bias | 793-938 | Polar residues | ||||
Sequence: SPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLT | ||||||
Compositional bias | 959-981 | Polar residues | ||||
Sequence: NVTSTGMPTSSSSSAFPRNTRNR | ||||||
Region | 959-1052 | Disordered | ||||
Sequence: NVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLTRRDHNRESMTQPVSGRAGTI | ||||||
Compositional bias | 982-999 | Basic and acidic residues | ||||
Sequence: QTFHGKTEKDKGGDDSSD | ||||||
Compositional bias | 1009-1026 | Polar residues | ||||
Sequence: SIGATGPSANNAEATIWS | ||||||
Domain | 1143-1192 | KA1 | ||||
Sequence: DPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 12 isoforms produced by Alternative splicing.
Q9TW45-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length1,192
- Mass (Da)126,349
- Last updated2000-05-01 v1
- Checksum32517D17BCAB46E0
Q9TW45-2
- Nameb
Q9TW45-3
- Namec
Q9TW45-4
- Named
- Differences from canonical
- 1-64: Missing
- 65-139: NLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGS → MFNAAYSSLLARFMCQPSSSSVTPIPEEEESLIPKRKVSEVVTTAPMAPTLTSSGKRRTVKVSPDGDHVTHNRKN
- 1034-1034: R → RSSTAAAHQPRGSSLHHSMSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSATAPIPVIVSPAVTKMLKENRRKLSEEAMAIRR
Q9TW45-5
- Namee
- Differences from canonical
- 1-64: Missing
- 65-139: NLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGS → MFNAAYSSLLARFMCQPSSSSVTPIPEEEESLIPKRKVSEVVTTAPMAPTLTSSGKRRTVKVSPDGDHVTHNRKN
- 825-1030: KPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSK → NPIVWQNLHLNSLLKSLLDSSAATSYETPRRPGIAGRRSEPSAATPRRRHQTMVVDARHLQTPPDTDRPYHFEDTTLDRQMRALYVSTASSRMTRGVLPTPPTSNSTSSSFIVEPLTHVAAASPDITTTTPTKSTVTTSPYFRRTPSFRMAVDDPPISINASITDDDCDGIIEIEREWSNGGTDSGDGRSTTTSHITANVSFGNNQ
- 1031-1192: Missing
Q9TW45-6
- Namef
- Differences from canonical
- 1-89: Missing
Q9TW45-7
- Nameg
- Differences from canonical
- 1-151: Missing
Q9TW45-8
- Nameh
- Differences from canonical
- 1-487: Missing
Q9TW45-9
- Namei
Q9TW45-10
- Namej
- Differences from canonical
- 535-535: S → SVSDHHHPY
Q9TW45-11
- Namek
- Differences from canonical
- 1-598: Missing
Q9TW45-12
- Namel
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2C9C376 | A0A2C9C376_CAEEL | par-1 | 1129 |
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MSSASVGKKPEHVNTPPGDNQQKSS | ||||||
Alternative sequence | VSP_053142 | 1-49 | in isoform b | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053141 | 1-64 | in isoform d and isoform e | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053639 | 1-86 | in isoform l | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053638 | 1-89 | in isoform f | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053140 | 1-130 | in isoform c | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053637 | 1-151 | in isoform g | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053636 | 1-487 | in isoform h | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053635 | 1-598 | in isoform k | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053634 | 1-963 | in isoform i | |||
Sequence: Missing | ||||||
Compositional bias | 34-158 | Polar residues | ||||
Sequence: DKQSSNQPPGQIPHSTNSGTRKSSGSGLKTANLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAA | ||||||
Alternative sequence | VSP_053143 | 50-66 | in isoform b | |||
Sequence: NSGTRKSSGSGLKTANL → MSRVSGYFMGISKKNGQK | ||||||
Alternative sequence | VSP_053144 | 65-139 | in isoform d and isoform e | |||
Sequence: NLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGS → MFNAAYSSLLARFMCQPSSSSVTPIPEEEESLIPKRKVSEVVTTAPMAPTLTSSGKRRTVKVSPDGDHVTHNRKN | ||||||
Sequence conflict | 84 | in Ref. 1; AAA97437 | ||||
Sequence: R → Q | ||||||
Alternative sequence | VSP_053640 | 87-138 | in isoform l | |||
Sequence: AQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSG → MTKKSYAFALDLDDLCCDDHPYSYSPPSTSSRHSAYYPSQQPRTFFPEYELT | ||||||
Sequence conflict | 96 | in Ref. 1; AAA97437 | ||||
Sequence: A → P | ||||||
Alternative sequence | VSP_053145 | 131-139 | in isoform c | |||
Sequence: GRSHPTSGS → MKFMWKPPD | ||||||
Alternative sequence | VSP_053146 | 488-535 | in isoform b | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053641 | 535 | in isoform j | |||
Sequence: S → SVSDHHHPY | ||||||
Compositional bias | 558-591 | Polar residues | ||||
Sequence: ASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAAT | ||||||
Compositional bias | 648-663 | Polar residues | ||||
Sequence: STATSSAAQPSTGITG | ||||||
Compositional bias | 727-760 | Polar residues | ||||
Sequence: TPAAGGTAATSSSSSSSATSTAPLQKSGSQISHA | ||||||
Compositional bias | 793-938 | Polar residues | ||||
Sequence: SPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLT | ||||||
Alternative sequence | VSP_053642 | 825-1030 | in isoform e | |||
Sequence: KPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSK → NPIVWQNLHLNSLLKSLLDSSAATSYETPRRPGIAGRRSEPSAATPRRRHQTMVVDARHLQTPPDTDRPYHFEDTTLDRQMRALYVSTASSRMTRGVLPTPPTSNSTSSSFIVEPLTHVAAASPDITTTTPTKSTVTTSPYFRRTPSFRMAVDDPPISINASITDDDCDGIIEIEREWSNGGTDSGDGRSTTTSHITANVSFGNNQ | ||||||
Compositional bias | 959-981 | Polar residues | ||||
Sequence: NVTSTGMPTSSSSSAFPRNTRNR | ||||||
Alternative sequence | VSP_053643 | 964-1032 | in isoform i | |||
Sequence: GMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLT → MSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSATAPIPVIVSPAVTKMLKENRRKLSEEAMAI | ||||||
Compositional bias | 982-999 | Basic and acidic residues | ||||
Sequence: QTFHGKTEKDKGGDDSSD | ||||||
Compositional bias | 1009-1026 | Polar residues | ||||
Sequence: SIGATGPSANNAEATIWS | ||||||
Alternative sequence | VSP_053644 | 1031-1192 | in isoform e | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053148 | 1034 | in isoform d | |||
Sequence: R → RSSTAAAHQPRGSSLHHSMSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSATAPIPVIVSPAVTKMLKENRRKLSEEAMAIRR | ||||||
Sequence conflict | 1141 | in Ref. 1; AAA97437 | ||||
Sequence: H → Y |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U22183 EMBL· GenBank· DDBJ | AAA97437.1 EMBL· GenBank· DDBJ | mRNA | ||
U40858 EMBL· GenBank· DDBJ | AAA83272.1 EMBL· GenBank· DDBJ | mRNA | ||
Z96102 EMBL· GenBank· DDBJ | CAB54262.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CAB54262.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CAB54263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CAB54263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CAJ85756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CAJ85756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CAQ16148.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CAQ16148.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CBL43447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CBL43447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CBO24859.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CBO24859.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CBW44387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CBW44388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CBW48399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CCE71393.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CCE71394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CCE71394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z96102 EMBL· GenBank· DDBJ | CCW45975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z81027 EMBL· GenBank· DDBJ | CCW45975.1 EMBL· GenBank· DDBJ | Genomic DNA |