Q9TW45 · PAR1_CAEEL

  • Protein
    Serine/threonine-protein kinase par-1
  • Gene
    par-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115).
Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813).
Regulates mes-1 expression during early embryogenesis (PubMed:11003841).
Critical role in postembryonic vulval morphogenesis (PubMed:12490197).
Involved in the establishment of neuronal polarity (PubMed:20023164).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site176-184ATP (UniProtKB | ChEBI)
Binding site199ATP (UniProtKB | ChEBI)
Active site292Proton acceptor

GO annotations

AspectTerm
Cellular Componentcell cortex
Cellular Componentcell periphery
Cellular Componentcytoplasm
Cellular ComponentP granule
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionmyosin II tail binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functiontau-protein kinase activity
Molecular Functionubiquitin protein ligase binding
Biological Processasymmetric neuroblast division
Biological Processasymmetric protein localization involved in cell fate determination
Biological Processembryonic pattern specification
Biological Processestablishment of cell polarity
Biological Processestablishment or maintenance of cell polarity
Biological Processintracellular signal transduction
Biological Processmicrotubule cytoskeleton organization
Biological Processpolarity specification of anterior/posterior axis
Biological Processvulval development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase par-1
  • EC number

Gene names

    • Name
      par-1
    • ORF names
      H39E23.1

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q9TW45
  • Secondary accessions
    • B1Q266
    • E0AHE2
    • E0AHE3
    • E1B6W1
    • G5EE60

Proteomes

Organism-specific databases

Subcellular Location

Note: Colocalizes with germ granules (P granules).

Keywords

Phenotypes & Variants

Disruption phenotype

Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003833221-1192Serine/threonine-protein kinase par-1
Modified residue325Phosphothreonine

Post-translational modification

Phosphorylated at Thr-325 probably by par-4.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).

Developmental stage

Maternally expressed.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9TW45let-99 Q213412EBI-1811687, EBI-1811800

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-25Polar residues
Region1-163Disordered
Compositional bias34-158Polar residues
Domain170-421Protein kinase
Domain440-482UBA
Region522-541Disordered
Compositional bias558-591Polar residues
Region558-601Disordered
Compositional bias648-663Polar residues
Region648-673Disordered
Compositional bias727-760Polar residues
Region727-938Disordered
Compositional bias793-938Polar residues
Compositional bias959-981Polar residues
Region959-1052Disordered
Compositional bias982-999Basic and acidic residues
Compositional bias1009-1026Polar residues
Domain1143-1192KA1

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

  • Sequence status
    Complete

This entry describes 12 isoforms produced by Alternative splicing.

Q9TW45-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,192
  • Mass (Da)
    126,349
  • Last updated
    2000-05-01 v1
  • Checksum
    32517D17BCAB46E0
MSSASVGKKPEHVNTPPGDNQQKSSKENQKSNKDKQSSNQPPGQIPHSTNSGTRKSSGSGLKTANLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRNDQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLGERKSDMDASEITMAQSLLSHSSINVSSSLGQHPAGVITREHVTSSSASGSSASPSRYSRSSATATGASITAGSALASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAGGTVVMSGTRHGGVQMRAQPTSRQATISLLQPPSYKPSSNTTQIAQIPPLFNRNSTATSSAAQPSTGITGTRKIADPKGRIPLNSTAVQGHRTATGAVAANNGGIPSHRDHAQQQQYMNQLTSSTMMSKLINKTPAAGGTAATSSSSSSSATSTAPLQKSGSQISHAPTEPVIREDDDENNSENQNGNVPLIGGVGPQTSPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLTRRDHNRESMTQPVSGRAGTIGASQGQQTAAALAAIREQSGPIAPGAGQVAPSLPIHEGDVKPRSLRFTWSMKTTSSLAPDDMMREIRKVLDANGCDYEQRERYMILCVHGDPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQELNL

Q9TW45-2

  • Name
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-49: Missing
    • 50-66: NSGTRKSSGSGLKTANL → MSRVSGYFMGISKKNGQK
    • 488-535: Missing

Q9TW45-3

  • Name
    c
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-4

  • Name
    d
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-64: Missing
    • 65-139: NLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGS → MFNAAYSSLLARFMCQPSSSSVTPIPEEEESLIPKRKVSEVVTTAPMAPTLTSSGKRRTVKVSPDGDHVTHNRKN
    • 1034-1034: R → RSSTAAAHQPRGSSLHHSMSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSATAPIPVIVSPAVTKMLKENRRKLSEEAMAIRR

Q9TW45-5

  • Name
    e
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-64: Missing
    • 65-139: NLKHPARPSTESSTSSSHHRRPAQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSGS → MFNAAYSSLLARFMCQPSSSSVTPIPEEEESLIPKRKVSEVVTTAPMAPTLTSSGKRRTVKVSPDGDHVTHNRKN
    • 825-1030: KPSMIHQSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSK → NPIVWQNLHLNSLLKSLLDSSAATSYETPRRPGIAGRRSEPSAATPRRRHQTMVVDARHLQTPPDTDRPYHFEDTTLDRQMRALYVSTASSRMTRGVLPTPPTSNSTSSSFIVEPLTHVAAASPDITTTTPTKSTVTTSPYFRRTPSFRMAVDDPPISINASITDDDCDGIIEIEREWSNGGTDSGDGRSTTTSHITANVSFGNNQ
    • 1031-1192: Missing

Q9TW45-6

  • Name
    f
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-7

  • Name
    g
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-8

  • Name
    h
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-9

  • Name
    i
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-963: Missing
    • 964-1032: GMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIWSKLSKLT → MSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSATAPIPVIVSPAVTKMLKENRRKLSEEAMAI

Q9TW45-10

  • Name
    j
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-11

  • Name
    k
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9TW45-12

  • Name
    l
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-86: Missing
    • 87-138: AQEMNGTSTATATGGGGTSGATTTASSGAPAASSGGSSARYSSSGRSHPTSG → MTKKSYAFALDLDDLCCDDHPYSYSPPSTSSRHSAYYPSQQPRTFFPEYELT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2C9C376A0A2C9C376_CAEELpar-11129

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-25Polar residues
Alternative sequenceVSP_0531421-49in isoform b
Alternative sequenceVSP_0531411-64in isoform d and isoform e
Alternative sequenceVSP_0536391-86in isoform l
Alternative sequenceVSP_0536381-89in isoform f
Alternative sequenceVSP_0531401-130in isoform c
Alternative sequenceVSP_0536371-151in isoform g
Alternative sequenceVSP_0536361-487in isoform h
Alternative sequenceVSP_0536351-598in isoform k
Alternative sequenceVSP_0536341-963in isoform i
Compositional bias34-158Polar residues
Alternative sequenceVSP_05314350-66in isoform b
Alternative sequenceVSP_05314465-139in isoform d and isoform e
Sequence conflict84in Ref. 1; AAA97437
Alternative sequenceVSP_05364087-138in isoform l
Sequence conflict96in Ref. 1; AAA97437
Alternative sequenceVSP_053145131-139in isoform c
Alternative sequenceVSP_053146488-535in isoform b
Alternative sequenceVSP_053641535in isoform j
Compositional bias558-591Polar residues
Compositional bias648-663Polar residues
Compositional bias727-760Polar residues
Compositional bias793-938Polar residues
Alternative sequenceVSP_053642825-1030in isoform e
Compositional bias959-981Polar residues
Alternative sequenceVSP_053643964-1032in isoform i
Compositional bias982-999Basic and acidic residues
Compositional bias1009-1026Polar residues
Alternative sequenceVSP_0536441031-1192in isoform e
Alternative sequenceVSP_0531481034in isoform d
Sequence conflict1141in Ref. 1; AAA97437

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U22183
EMBL· GenBank· DDBJ
AAA97437.1
EMBL· GenBank· DDBJ
mRNA
U40858
EMBL· GenBank· DDBJ
AAA83272.1
EMBL· GenBank· DDBJ
mRNA
Z96102
EMBL· GenBank· DDBJ
CAB54262.2
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CAB54262.2
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CAB54263.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CAB54263.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CAJ85756.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CAJ85756.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CAQ16148.2
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CAQ16148.2
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CBL43447.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CBL43447.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CBO24859.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CBO24859.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CBW44387.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CBW44388.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CBW48399.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CCE71393.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CCE71394.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CCE71394.1
EMBL· GenBank· DDBJ
Genomic DNA
Z96102
EMBL· GenBank· DDBJ
CCW45975.1
EMBL· GenBank· DDBJ
Genomic DNA
Z81027
EMBL· GenBank· DDBJ
CCW45975.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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