Q9TVK3 · O16F_CONAB
- ProteinConotoxin AbVIF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | ion channel inhibitor activity | |
Molecular Function | toxin activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameConotoxin AbVIF
Organism names
- Taxonomic lineage
Accessions
- Primary accessionQ9TVK3
- Secondary accessions
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, disulfide bond, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: VLIIAVLFLTACQLTTA | ||||||
Propeptide | PRO_0000392120 | 18-40 | ||||
Sequence: ETSSRGKQKHRALRSTDKNSRMS | ||||||
Disulfide bond | 43↔57 | |||||
Sequence: CTPPGGYCYHPDPCC | ||||||
Peptide | PRO_0000392121 | 43-69 | Conotoxin AbVIF | |||
Sequence: CTPPGGYCYHPDPCCSQVCNFPRKHCL | ||||||
Disulfide bond | 50↔61 | |||||
Sequence: CYHPDPCCSQVC | ||||||
Disulfide bond | 56↔68 | |||||
Sequence: CCSQVCNFPRKHC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom duct.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-41 | Disordered | ||||
Sequence: SSRGKQKHRALRSTDKNSRMSK | ||||||
Compositional bias | 21-38 | Basic and acidic residues | ||||
Sequence: SRGKQKHRALRSTDKNSR |
Domain
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).
Sequence similarities
Belongs to the conotoxin O1 superfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length69
- Mass (Da)7,726
- Last updated2000-05-01 v1
- ChecksumCE5CC0645679C033
Features
Showing features for non-terminal residue, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Compositional bias | 21-38 | Basic and acidic residues | ||||
Sequence: SRGKQKHRALRSTDKNSR | ||||||
Sequence conflict | 24 | in Ref. 1 and 2; AAD48241 | ||||
Sequence: K → E | ||||||
Sequence conflict | 28 | in Ref. 1 and 2; AAD48241 | ||||
Sequence: R → L | ||||||
Sequence conflict | 60 | in Ref. 1 and 2; AAD48248/AAD48247/AAD48246 | ||||
Sequence: V → Y |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF089986 EMBL· GenBank· DDBJ | AAD48241.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089987 EMBL· GenBank· DDBJ | AAD48242.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089988 EMBL· GenBank· DDBJ | AAD48243.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089989 EMBL· GenBank· DDBJ | AAD48244.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089990 EMBL· GenBank· DDBJ | AAD48245.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089991 EMBL· GenBank· DDBJ | AAD48246.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089992 EMBL· GenBank· DDBJ | AAD48247.1 EMBL· GenBank· DDBJ | mRNA | ||
AF089993 EMBL· GenBank· DDBJ | AAD48248.1 EMBL· GenBank· DDBJ | mRNA |