Q9TU72 · S53A1_NEOVI
- ProteinSolute carrier family 53 member 1
- GeneXPR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids696 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity).
Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (By similarity).
Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (By similarity).
(Microbial infection) Receptor for xenotropic and polytropic murine leukemia (X- and P-MLV) retroviruses.
Catalytic activity
- phosphate(in) = phosphate(out)This reaction proceeds in the forward direction.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 22 | Important for inositol polyphosphate binding | ||||
Sequence: Y | ||||||
Site | 26 | Important for inositol polyphosphate binding | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | inositol hexakisphosphate binding | |
Molecular Function | phosphate transmembrane transporter activity | |
Molecular Function | virus receptor activity | |
Biological Process | cellular response to phosphate starvation | |
Biological Process | intracellular phosphate ion homeostasis | |
Biological Process | phosphate ion transmembrane transport |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 53 member 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Neogale
Accessions
- Primary accessionQ9TU72
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-236 | Cytoplasmic | ||||
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRMPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTEFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDPQKAMKRLRVPSLGAAQPAPAWTTFR | ||||||
Transmembrane | 237-257 | Helical | ||||
Sequence: VGLFCGIFIVLNITLVLAAVF | ||||||
Topological domain | 258-264 | Extracellular | ||||
Sequence: KLETDRS | ||||||
Transmembrane | 265-285 | Helical | ||||
Sequence: IWPLIRIYRGGFLLIEFLFLL | ||||||
Topological domain | 286-318 | Cytoplasmic | ||||
Sequence: GINTYGWRQAGVNHVLIFELNPRNNLSHQHLFE | ||||||
Transmembrane | 319-339 | Helical | ||||
Sequence: IAGFLGILWCLSLLACFFAPI | ||||||
Topological domain | 340-345 | Extracellular | ||||
Sequence: SVIPTY | ||||||
Transmembrane | 346-368 | Helical | ||||
Sequence: VYPLVLYGFMVFFLINPTKTFYY | ||||||
Topological domain | 369-376 | Cytoplasmic | ||||
Sequence: KSRFWLLK | ||||||
Transmembrane | 377-397 | Helical | ||||
Sequence: LLFRVFTAPFHKVGFADFWLA | ||||||
Topological domain | 398-402 | Extracellular | ||||
Sequence: DQLNS | ||||||
Transmembrane | 403-423 | Helical | ||||
Sequence: LSVILMDLEYMICFYSFELKW | ||||||
Topological domain | 424-473 | Cytoplasmic | ||||
Sequence: DESGGLLPNNSEEPEICHKYSYGVRAIVQCVPAWLRFIQCLRRYRDTKRA | ||||||
Transmembrane | 474-496 | Helical | ||||
Sequence: FPHLVNAGKYSTTFFTVTFAALY | ||||||
Topological domain | 497-507 | Extracellular | ||||
Sequence: STHKERGHSDT | ||||||
Transmembrane | 508-528 | Helical | ||||
Sequence: MVFFYLWIVFCIISSCYTLIW | ||||||
Topological domain | 529-696 | Cytoplasmic | ||||
Sequence: DLKMDWGLFDKNAGENTFLREEIVYPQRAYYYCTIIEDVILRFAWTVQISITSMTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRDRQKNRPWKYSQSISLRRPRLASQSKARDTKVLIEDTDDEANT |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000315859 | 1-696 | Solute carrier family 53 member 1 | |||
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRMPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTEFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDPQKAMKRLRVPSLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLVLYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFELKWDESGGLLPNNSEEPEICHKYSYGVRAIVQCVPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFTVTFAALYSTHKERGHSDTMVFFYLWIVFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQRAYYYCTIIEDVILRFAWTVQISITSMTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRDRQKNRPWKYSQSISLRRPRLASQSKARDTKVLIEDTDDEANT | ||||||
Modified residue | 668 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 690 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-177 | SPX | ||||
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRMPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTEFRKILKKHDKILETSRGADWRV | ||||||
Region | 158-165 | Important for inositol polyphosphate binding | ||||
Sequence: KILKKHDK | ||||||
Domain | 439-643 | EXS | ||||
Sequence: ICHKYSYGVRAIVQCVPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFTVTFAALYSTHKERGHSDTMVFFYLWIVFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQRAYYYCTIIEDVILRFAWTVQISITSMTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLE | ||||||
Region | 648-696 | Disordered | ||||
Sequence: QDDGVRDRQKNRPWKYSQSISLRRPRLASQSKARDTKVLIEDTDDEANT | ||||||
Compositional bias | 675-696 | Basic and acidic residues | ||||
Sequence: ASQSKARDTKVLIEDTDDEANT |
Domain
The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.
Sequence similarities
Belongs to the SYG1 (TC 2.A.94) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length696
- Mass (Da)81,581
- Last updated2000-05-01 v1
- Checksum479997D73DB5837B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 675-696 | Basic and acidic residues | ||||
Sequence: ASQSKARDTKVLIEDTDDEANT |
Keywords
- Technical term