Q9TU72 · S53A1_NEOVI

Function

function

Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity).
Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (By similarity).
(Microbial infection) Receptor for xenotropic and polytropic murine leukemia (X- and P-MLV) retroviruses.

Catalytic activity

Features

Showing features for site.

TypeIDPosition(s)Description
Site22Important for inositol polyphosphate binding
Site26Important for inositol polyphosphate binding

GO annotations

AspectTerm
Cellular ComponentGolgi apparatus
Cellular Componentplasma membrane
Molecular Functionefflux transmembrane transporter activity
Molecular Functioninositol hexakisphosphate binding
Molecular Functionphosphate transmembrane transporter activity
Molecular Functionvirus receptor activity
Biological Processcellular response to phosphate starvation
Biological Processintracellular phosphate ion homeostasis
Biological Processphosphate ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 53 member 1
  • Alternative names
    • Phosphate exporter SLC53A1
    • Xenotropic and polytropic retrovirus receptor 1

Gene names

    • Name
      XPR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Neogale

Accessions

  • Primary accession
    Q9TU72

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-236Cytoplasmic
Transmembrane237-257Helical
Topological domain258-264Extracellular
Transmembrane265-285Helical
Topological domain286-318Cytoplasmic
Transmembrane319-339Helical
Topological domain340-345Extracellular
Transmembrane346-368Helical
Topological domain369-376Cytoplasmic
Transmembrane377-397Helical
Topological domain398-402Extracellular
Transmembrane403-423Helical
Topological domain424-473Cytoplasmic
Transmembrane474-496Helical
Topological domain497-507Extracellular
Transmembrane508-528Helical
Topological domain529-696Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003158591-696Solute carrier family 53 member 1
Modified residue668Phosphoserine
Modified residue690Phosphothreonine

Keywords

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-177SPX
Region158-165Important for inositol polyphosphate binding
Domain439-643EXS
Region648-696Disordered
Compositional bias675-696Basic and acidic residues

Domain

The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.

Sequence similarities

Belongs to the SYG1 (TC 2.A.94) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    696
  • Mass (Da)
    81,581
  • Last updated
    2000-05-01 v1
  • Checksum
    479997D73DB5837B
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRMPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTEFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDPQKAMKRLRVPSLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLVLYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFELKWDESGGLLPNNSEEPEICHKYSYGVRAIVQCVPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFTVTFAALYSTHKERGHSDTMVFFYLWIVFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQRAYYYCTIIEDVILRFAWTVQISITSMTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRDRQKNRPWKYSQSISLRRPRLASQSKARDTKVLIEDTDDEANT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias675-696Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF131100
EMBL· GenBank· DDBJ
AAF03486.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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