Q9TEC1 · CYB_CHEMY
- ProteinCytochrome b
- GeneMT-CYB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids381 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Cofactor
Note: Binds 2 heme b groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 84 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 98 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 183 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 197 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 202 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionQ9TEC1
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 34-54 | Helical | ||||
Sequence: FGSLLATCLALQIITGIFLAM | ||||||
Transmembrane | 78-99 | Helical | ||||
Sequence: WLIRNMHANGASLFFMCIYLHI | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: WNTGIILLLLVMATAFVGYVL | ||||||
Transmembrane | 179-199 | Helical | ||||
Sequence: FFTFHFLLPFAITGLTAVHLL | ||||||
Transmembrane | 227-247 | Helical | ||||
Sequence: YKDLLGLILMLTFLLTLTLFS | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: LGGVLALLFSILILFLMPTLH | ||||||
Transmembrane | 321-341 | Helical | ||||
Sequence: LTQILFWSLVADLLVLTWIGG | ||||||
Transmembrane | 348-368 | Helical | ||||
Sequence: FIIIGQVASTFYFLILLLLMP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000060775 | 1-381 | Cytochrome b | |||
Sequence: MATNLRKTHPMMKIINNLVIDLPSPSNISAWWNFGSLLATCLALQIITGIFLAMHYSPDISMAFSSIAHITRDVQYGWLIRNMHANGASLFFMCIYLHIGRGIYYGSYLYKETWNTGIILLLLVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVQWIWGGFSVDNATLTRFFTFHFLLPFAITGLTAVHLLFLHETGSNNPTGLNSNTDKIPFHPYFSYKDLLGLILMLTFLLTLTLFSPYLLGDPDNFTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILILFLMPTLHTSKQRTASFRPLTQILFWSLVADLLVLTWIGGQPVEDPFIIIGQVASTFYFLILLLLMPAAGMIENKMLNLK |
Interaction
Subunit
The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
Structure
Sequence
- Sequence statusComplete
- Length381
- Mass (Da)42,859
- Last updated2000-05-01 v1
- ChecksumDE980F3AFE9E17D7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB012104 EMBL· GenBank· DDBJ | BAA79209.1 EMBL· GenBank· DDBJ | Genomic DNA |