Q9SZE4 · VP322_ARATH
- ProteinVacuolar protein sorting-associated protein 32 homolog 2
- GeneVPS32.2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids219 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ESCRT III complex | |
Cellular Component | plasma membrane | |
Biological Process | intralumenal vesicle formation | |
Biological Process | protein transport | |
Biological Process | vacuolar transport |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameVacuolar protein sorting-associated protein 32 homolog 2
- Short namesAtVPS32-2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SZE4
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000368201 | 1-219 | Vacuolar protein sorting-associated protein 32 homolog 2 | |||
Sequence: MMNRLFGKPKQEANALQTLDKLNETLEMLEKKEKVLLKKAGAEVEKAKEYSRAKNKRAAIQCLKRKRLYEGQVEQLGNFQLRIHDQMIMLEGAKATTETVDALRSGASAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALATPMGAAADFDEDELAAELDELESEELESQLLQPATTAPPLPSVPVPAGRQPARPVPQKRTAEEEELAALQAEMAL |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the endosomal sorting required for transport complex III (ESCRT-III), composed at least of VPS2, VPS20, VPS24 and VPS32 (By similarity).
Interacts with SKD1 (PubMed:20663085, PubMed:24812106).
Interacts with BRO1/ALIX (PubMed:22639582, PubMed:26342016).
Interacts with SKD1 (PubMed:20663085, PubMed:24812106).
Interacts with BRO1/ALIX (PubMed:22639582, PubMed:26342016).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9SZE4 | VPS2.2 Q0WTY4 | 3 | EBI-3865953, EBI-3865323 | |
BINARY | Q9SZE4 | VPS20.2 Q9FY89 | 3 | EBI-3865953, EBI-3865360 | |
BINARY | Q9SZE4 | VPS32.1 O82197 | 4 | EBI-3865953, EBI-3865938 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 10-41 | |||||
Sequence: KQEANALQTLDKLNETLEMLEKKEKVLLKKAG | ||||||
Coiled coil | 117-176 | |||||
Sequence: TNIDDVDKTMDEINEQTENMKQIQEALATPMGAAADFDEDELAAELDELESEELESQLLQ | ||||||
Region | 168-219 | Disordered | ||||
Sequence: EELESQLLQPATTAPPLPSVPVPAGRQPARPVPQKRTAEEEELAALQAEMAL | ||||||
Compositional bias | 181-195 | Pro residues | ||||
Sequence: APPLPSVPVPAGRQP |
Sequence similarities
Belongs to the SNF7 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9SZE4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length219
- Mass (Da)24,333
- Last updated2000-05-01 v1
- Checksum711E9EEB70450D6B
Q9SZE4-2
- Name2
- Differences from canonical
- 1-27: Missing
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_036804 | 1-27 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 181-195 | Pro residues | ||||
Sequence: APPLPSVPVPAGRQP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL078470 EMBL· GenBank· DDBJ | CAB43930.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161574 EMBL· GenBank· DDBJ | CAB79674.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE85593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE85594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE85595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY042853 EMBL· GenBank· DDBJ | AAK68793.1 EMBL· GenBank· DDBJ | mRNA | ||
AY072490 EMBL· GenBank· DDBJ | AAL66905.1 EMBL· GenBank· DDBJ | mRNA | ||
AY088519 EMBL· GenBank· DDBJ | AAM66053.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |