Q9SZ45 · MICU_ARATH
- ProteinCalcium uptake protein, mitochondrial
- GeneMICU
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids498 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Calcium-binding protein maintaining matrix calcium levels at low concentration. Regulates mitochondrial calcium dynamics in planta by restricting influx.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 222 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 224 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 226 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 233 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 256 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 258 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 260 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 262 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 267 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 450 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 452 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 454 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 456 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 461 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial intermembrane space | |
Cellular Component | mitochondrion | |
Molecular Function | calcium ion binding | |
Biological Process | calcium ion transport | |
Biological Process | mitochondrial calcium ion transmembrane transport | |
Biological Process | negative regulation of mitochondrial calcium ion concentration |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalcium uptake protein, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SZ45
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Located at the inner mitochondrial membrane and/or in the intermembrane space.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-29 | Mitochondrion | ||||
Sequence: MPALSHYRSVSSLPSVDRSFLLIQRLRIH | ||||||
Chain | PRO_0000438705 | 30-498 | Calcium uptake protein, mitochondrial | |||
Sequence: GSSSSFPESSPSASILSGADPLKCTVSGGSLAKWITGISAGSALGFLYWSSGSSDSISGLFGGSNLLSFADSSTPSVCGVKVGDLKPRSFIPKLSLPGYSSGFIFGDAYRRKIFFNYEKRLRLQSPPEKVFEYFASVRTDKGEILMKPADLMRAIVPVFPPSESHLVREGYLTGERNPGELRCSPSEFFMLFDVDNDGLISFKEYIFFVTLLSIPESSFAVAFKMFDTDNNGEIDKEEFKTVMSLMRSQHRQGVGHRDGLRTGLHMTGSVEDGGLVEYFFGKDGSQKLKHDKFTKFMKDLTEEMLRLEFAHYDYKRRGSISAKDFALSMVAAADASHLSKLLDRVESLSEHPHLRDMRISLKEFKQFDELRSKLGPFSLALFAYGKANGLLTMKDFKRAASQVCGITLSDNVIEIAFHVFDSNQDGNLSVDEFLRVLHRRERDVAQPIAKGLSRYFSDGWKGSKNCSSS |
Proteomic databases
Expression
Tissue specificity
Expressed in both green and non-green tissues, including roots, shoots, floral buds and pollen.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 216-241 | EF-hand 1 | ||||
Sequence: EFFMLFDVDNDGLISFKEYIFFVTLL | ||||||
Domain | 243-278 | EF-hand 2 | ||||
Sequence: IPESSFAVAFKMFDTDNNGEIDKEEFKTVMSLMRSQ | ||||||
Domain | 329-364 | EF-hand 3 | ||||
Sequence: LTEEMLRLEFAHYDYKRRGSISAKDFALSMVAAADA | ||||||
Domain | 437-472 | EF-hand 4 | ||||
Sequence: LSDNVIEIAFHVFDSNQDGNLSVDEFLRVLHRRERD |
Domain
The EF-hand domains have high affinity for calcium.
Sequence similarities
Belongs to the MICU1 family. MICU1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q9SZ45-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length498
- Mass (Da)55,415
- Last updated2000-05-01 v1
- ChecksumD6B1CDA90380A16C
Q9SZ45-2
- Name2
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL021636 EMBL· GenBank· DDBJ | CAA16584.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161580 EMBL· GenBank· DDBJ | CAB79924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE85999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE86000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY072163 EMBL· GenBank· DDBJ | AAL59985.1 EMBL· GenBank· DDBJ | mRNA | ||
AY122982 EMBL· GenBank· DDBJ | AAM67515.1 EMBL· GenBank· DDBJ | mRNA |