Q9SWA6 · SNI1_ARATH

Function

function

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:24207055).
Transcription repressor that prevents expression of pathogenesis-related genes (PR) via histone modifications and binding negative cis-acting elements at their promoters (PubMed:16766691, PubMed:17369431, PubMed:20935179, PubMed:21320694).
Negative regulator of hypersensitive response (HR) and systemic acquired resistance (SAR) required to dampen the basal expression of pathogenesis related (PR) genes (PubMed:10458608, PubMed:16766691, PubMed:17360504, PubMed:21149701).
Functions synergistically with NTL9/CBNAC as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae (PubMed:22826500).
Binds to the PR1 gene promoter to suppress defense response in the absence of pathogen challenge and is removed in response to induction (PubMed:21320694, PubMed:22826500).
Negatively regulates both gene expression and DNA recombination during pathogen infection, thus being involved in short-term defense response and a long-term survival strategy (PubMed:17360504).
Prevents effective immune responses that involve activation of DNA damage responses, probably by negatively regulating the DNA damage sensors RAD17 and ATR (PubMed:24207055).
Negative regulator of defenses against the beet cyst nematode H.schachtii (PubMed:18321188).

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular ComponentSmc5-Smc6 complex
Molecular Functiontranscription cis-regulatory region binding
Biological Processchromatin remodeling
Biological Processdefense response to nematode
Biological ProcessDNA damage response
Biological ProcessDNA repair
Biological Processnegative regulation of defense response
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of systemic acquired resistance
Biological Processplant-type hypersensitive response
Biological Processsomatic cell DNA recombination
Biological Processsystemic acquired resistance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Negative regulator of systemic acquired resistance SNI1
  • Alternative names
    • Non-structural maintenance of chromosome element 5
      (Non-SMC element 5
      )
    • Protein SUPPRESSOR OF NPR1, INDUCIBLE 1
      (Suppressor of npr1-1
      )

Gene names

    • Name
      SNI1
    • Synonyms
      NSE5
    • ORF names
      F28J12.3
    • Ordered locus names
      At4g18470

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SWA6
  • Secondary accessions
    • Q8LGF4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Note: Also detectable in some fluorescent loci peripheral to the nucleus.

Keywords

Phenotypes & Variants

Disruption phenotype

Accumulation of DNA damage leading to constitutively activated DNA damage responses (DDR) (PubMed:24207055).
Increased basal expression of pathogenesis-related (PR) genes (e.g. PR1) and hypersensitive response (HR) (PubMed:16766691, PubMed:17360504, PubMed:17369431, PubMed:20935179, PubMed:21149701, PubMed:21320694).
Chromatin modifications at the PR-1 promoter that mimic induction (e.g. AcH3 and MeH3K4) (PubMed:16766691).
Dwarf plants with distorted leaves, reduced root length, early flowering and reduced fertility (PubMed:16766691, PubMed:17360504, PubMed:21320694).
Decreased susceptibility to the beet cyst nematode H.schachtii (PubMed:18321188).
Mutant plants display enhanced resistance to the bacterial pathogen P.syringae pv. tomato DC3000 (PubMed:22826500).
Constitutively elevated levels of somatic homologous recombination (PubMed:17360504).
Suppressor of the npr1-1 mutant phenotypes, including systemic acquired resistance (SAR) and normal levels of PR1 restoration (PubMed:10458608, PubMed:20935179).

Variants

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The viewer provides 59 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004383671-432Negative regulator of systemic acquired resistance SNI1

Proteomic databases

Expression

Tissue specificity

Expressed at low levels in the veins.

Gene expression databases

Interaction

Subunit

Interacts with SSN2 (PubMed:21320694).
Binds to NTL9/CBNAC to promote its binding to promoters of target genes (PubMed:22826500).
Component of the SMC5-SMC6 complex which consists at least of SMC5 and SMC6B. Interacts with RAD17 (PubMed:24207055).

Protein-protein interaction databases

Structure

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    48,812
  • Last updated
    2000-05-01 v1
  • Checksum
    2A577F53213B0C3D
MSKETKGNNNTSRVMSGYGGSLEANTLAMIDSTGAKDSRDANEDRLQYLEAVRAASLVPENGIPPTNKMYQAIFRILRFGKTLELITASFQLLTQLHQRFPWVYVSDSADQLDIVDEAWSPFNFGSDVDSDEKDLSVRSLFLQQLIQNMNKRVNESEESDLKILGNMFLFKYLAHVLKLDFTPRNQVYEETMNWSLLKESFLNLLLASRKVNFKLLMKDYLSTMCASIDADEKSISLVELHKDMLTAMKELLVMIMELDTSKKKADLEGITSRGDGVRTPAMEIILDELTYDGYLLSKFLQVFDDPKWKLEIVLQYLTKYIPKPVVRTRRTTVPQAEDSKTLNGILKTFSNGTNPKNITKKIGPDIVQILIGHAFLARLTFSDPHEGDSISEICSSIISAFTSLKRVDQKIEILPFGKEVLFTAGMVLKAKA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict142in Ref. 5; AAM60892
Sequence conflict362in Ref. 5; AAM60892

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF169596
EMBL· GenBank· DDBJ
AAD50900.1
EMBL· GenBank· DDBJ
mRNA
AL021710
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002687
EMBL· GenBank· DDBJ
AEE84048.1
EMBL· GenBank· DDBJ
Genomic DNA
BT029212
EMBL· GenBank· DDBJ
ABJ17147.1
EMBL· GenBank· DDBJ
mRNA
AY084302
EMBL· GenBank· DDBJ
AAM60892.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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