Q9SVY1 · ZWIP2_ARATH
- ProteinZinc finger protein WIP2
- GeneWIP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids383 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth. In Arabidopsis, the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712).
May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580).
Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392).
May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580).
Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392).
Miscellaneous
The fruits of the gain-of-function mutant ntt-3D (T-DNA tagging) fail to dehisce.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Biological Process | cell fate determination | |
Biological Process | fruit replum development | |
Biological Process | pollen tube growth | |
Biological Process | primary root development | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of gene expression | |
Biological Process | transmitting tissue development |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein WIP2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SVY1
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced fertility, fruit length and seed set (PubMed:17600712).
Reduced replum width and cell number (PubMed:25039392).
Reduced replum width and cell number (PubMed:25039392).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000431316 | 1-383 | Zinc finger protein WIP2 | |||
Sequence: MTDPYSNFFTDWFKSNPFHHYPNSSTNPSPHPLPPVTPPSSFFFFPQSGDLRRPPPPPTPPPSPPLREALPLLSLSPANKQQDHHHNHDHLIQEPPSTSMDVDYDHHHQDDHHNLDDDDHDVTVALHIGLPSPSAQEMASLLMMSSSSSSSRTTHHHEDMNHKKDLDHEYSHGAVGGGEDDDEDSVGGDGGCRISRLNKGQYWIPTPSQILIGPTQFSCPVCFKTFNRYNNMQMHMWGHGSQYRKGPESLRGTQPTGMLRLPCYCCAPGCRNNIDHPRAKPLKDFRTLQTHYKRKHGIKPFMCRKCGKAFAVRGDWRTHEKNCGKLWYCICGSDFKHKRSLKDHIKAFGNGHGAYGIDGFDEEDEPASEVEQLDNDHESMQSK |
Proteomic databases
Interaction
Subunit
Can form homodimers. Interacts with BLH9, STM, AGL8/FUL, AGL1/SHP1 and AGL5/SHP2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9SVY1 | AGL5 P29385 | 3 | EBI-1999175, EBI-621949 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 19-118 | Disordered | ||||
Sequence: HHYPNSSTNPSPHPLPPVTPPSSFFFFPQSGDLRRPPPPPTPPPSPPLREALPLLSLSPANKQQDHHHNHDHLIQEPPSTSMDVDYDHHHQDDHHNLDDD | ||||||
Compositional bias | 27-41 | Pro residues | ||||
Sequence: NPSPHPLPPVTPPSS | ||||||
Compositional bias | 50-68 | Pro residues | ||||
Sequence: DLRRPPPPPTPPPSPPLRE | ||||||
Compositional bias | 100-118 | Basic and acidic residues | ||||
Sequence: MDVDYDHHHQDDHHNLDDD | ||||||
Region | 147-191 | Disordered | ||||
Sequence: SSSSSRTTHHHEDMNHKKDLDHEYSHGAVGGGEDDDEDSVGGDGG | ||||||
Compositional bias | 152-179 | Basic and acidic residues | ||||
Sequence: RTTHHHEDMNHKKDLDHEYSHGAVGGGE | ||||||
Zinc finger | 217-239 | C2H2-type 1 | ||||
Sequence: FSCPVCFKTFNRYNNMQMHMWGH | ||||||
Zinc finger | 264-296 | C2H2-type 2; atypical | ||||
Sequence: YCCAPGCRNNIDHPRAKPLKDFRTLQTHYKRKH | ||||||
Motif | 293-296 | Nuclear localization signal | ||||
Sequence: KRKH | ||||||
Zinc finger | 301-323 | C2H2-type 3; atypical | ||||
Sequence: FMCRKCGKAFAVRGDWRTHEKNC | ||||||
Zinc finger | 327-352 | C2H2-type 4; atypical | ||||
Sequence: WYCICGSDFKHKRSLKDHIKAFGNGH | ||||||
Motif | 336-339 | Nuclear localization signal | ||||
Sequence: KHKR | ||||||
Region | 361-383 | Disordered | ||||
Sequence: DEEDEPASEVEQLDNDHESMQSK |
Sequence similarities
Belongs to the WIP C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length383
- Mass (Da)43,337
- Last updated2000-05-01 v1
- Checksum9DDDCEE6E66A4506
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-41 | Pro residues | ||||
Sequence: NPSPHPLPPVTPPSS | ||||||
Compositional bias | 50-68 | Pro residues | ||||
Sequence: DLRRPPPPPTPPPSPPLRE | ||||||
Compositional bias | 100-118 | Basic and acidic residues | ||||
Sequence: MDVDYDHHHQDDHHNLDDD | ||||||
Sequence conflict | 117 | in Ref. 4; AAO64176 and 6; BAF00501 | ||||
Sequence: D → G | ||||||
Compositional bias | 152-179 | Basic and acidic residues | ||||
Sequence: RTTHHHEDMNHKKDLDHEYSHGAVGGGE | ||||||
Sequence conflict | 184 | in Ref. 4; AAO64176 and 6; BAF00501 | ||||
Sequence: D → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF254447 EMBL· GenBank· DDBJ | AAL55722.1 EMBL· GenBank· DDBJ | mRNA | ||
AL049660 EMBL· GenBank· DDBJ | CAB41188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE79685.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT005772 EMBL· GenBank· DDBJ | AAO64176.1 EMBL· GenBank· DDBJ | mRNA | ||
BT021089 EMBL· GenBank· DDBJ | AAX12859.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228585 EMBL· GenBank· DDBJ | BAF00501.1 EMBL· GenBank· DDBJ | mRNA |