Q9STH1 · HSOP3_ARATH
- ProteinHsp70-Hsp90 organizing protein 3
- GeneHOP3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids558 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity).
Involved in acclimation to heat
Involved in acclimation to heat
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | Hsp90 protein binding | |
Molecular Function | preprotein binding | |
Biological Process | chaperone-mediated protein complex assembly | |
Biological Process | heat acclimation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHsp70-Hsp90 organizing protein 3
- Short namesAtHop3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9STH1
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
Decreased thermotolerance after a long recovery (2 days) under nonstress conditions following an acclimation heat treatment.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 113 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000426703 | 1-558 | Hsp70-Hsp90 organizing protein 3 | |||
Sequence: MAEEAKSKGNAAFSSGDYATAITHFTEAINLSPTNHILYSNRSASYASLHRYEEALSDAKKTIELKPDWSKGYSRLGAAFIGLSKFDEAVDSYKKGLEIDPSNEMLKSGLADASRSRVSSKSNPFVDAFQGKEMWEKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLYMKDKRVMKALGVLLNVKFGGSSGEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALKEKGEGNVAYKKKDFGRAVEHYTKAMELDDEDISYLTNRAAVYLEMGKYEECIEDCDKAVERGRELRSDFKMIARALTRKGSALVKMARCSKDFEPAIETFQKALTEHRNPDTLKKLNDAEKVKKELEQQEYFDPTIAEEEREKGNGFFKEQKYPEAVKHYSEAIKRNPNDVRAYSNRAACYTKLGALPEGLKDAEKCIELDPSFTKGYSRKGAIQFFMKEYDKAMETYQEGLKHDPKNQEFLDGVRRCVEQINKASRGDLTPEELKERQAKAMQDPEVQNILSDPVMRQVLVDFQENPKAAQEHMKNPMVMNKIQKLVSAGIVQVR |
Post-translational modification
Phosphorylated.
Acetylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 2-35 | TPR 1 | ||||
Sequence: AEEAKSKGNAAFSSGDYATAITHFTEAINLSPTN | ||||||
Repeat | 37-69 | TPR 2 | ||||
Sequence: ILYSNRSASYASLHRYEEALSDAKKTIELKPDW | ||||||
Repeat | 70-103 | TPR 3 | ||||
Sequence: SKGYSRLGAAFIGLSKFDEAVDSYKKGLEIDPSN | ||||||
Domain | 131-170 | STI1 1 | ||||
Sequence: GKEMWEKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLY | ||||||
Repeat | 136-173 | TPR 4 | ||||
Sequence: EKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLYMKD | ||||||
Region | 191-232 | Disordered | ||||
Sequence: SSGEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALK | ||||||
Compositional bias | 193-232 | Basic and acidic residues | ||||
Sequence: GEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALK | ||||||
Motif | 227-244 | Bipartite nuclear localization signal | ||||
Sequence: KEKALKEKGEGNVAYKKK | ||||||
Repeat | 230-263 | TPR 5 | ||||
Sequence: ALKEKGEGNVAYKKKDFGRAVEHYTKAMELDDED | ||||||
Repeat | 265-297 | TPR 6 | ||||
Sequence: SYLTNRAAVYLEMGKYEECIEDCDKAVERGREL | ||||||
Repeat | 305-342 | TPR 7 | ||||
Sequence: ARALTRKGSALVKMARCSKDFEPAIETFQKALTEHRNP | ||||||
Repeat | 369-402 | TPR 8 | ||||
Sequence: AEEEREKGNGFFKEQKYPEAVKHYSEAIKRNPND | ||||||
Repeat | 404-436 | TPR 9 | ||||
Sequence: RAYSNRAACYTKLGALPEGLKDAEKCIELDPSF | ||||||
Repeat | 437-470 | TPR 10 | ||||
Sequence: TKGYSRKGAIQFFMKEYDKAMETYQEGLKHDPKN | ||||||
Domain | 507-546 | STI1 2 | ||||
Sequence: DPEVQNILSDPVMRQVLVDFQENPKAAQEHMKNPMVMNKI |
Domain
The tetratricopeptide repeat (TPR) domain, forming a carboxylate clamp (CC), mediates interaction with the highly conserved 'EEVD' motif at the C-terminal ends of HSP90 and HSP70.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9STH1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length558
- Mass (Da)63,706
- Last updated2000-05-01 v1
- Checksum47010D35F0F98DB9
Q9STH1-2
- Name2
Features
Showing features for sequence conflict, compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 98 | in Ref. 4; BAH19733 | ||||
Sequence: E → G | ||||||
Compositional bias | 193-232 | Basic and acidic residues | ||||
Sequence: GEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALK | ||||||
Sequence conflict | 374 | in Ref. 3; AAM98143 | ||||
Sequence: E → K | ||||||
Alternative sequence | VSP_053940 | 523-530 | in isoform 2 | |||
Sequence: LVDFQENP → KAVASIVF | ||||||
Alternative sequence | VSP_053941 | 531-558 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL080318 EMBL· GenBank· DDBJ | CAB45987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161534 EMBL· GenBank· DDBJ | CAB78283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE83125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE83126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY140001 EMBL· GenBank· DDBJ | AAM98143.1 EMBL· GenBank· DDBJ | mRNA | ||
AK317040 EMBL· GenBank· DDBJ | BAH19733.1 EMBL· GenBank· DDBJ | mRNA |