Q9STG6 · DUT_ARATH
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- GeneDUT
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids166 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.
Miscellaneous
Silencing of DUT leads to high seedling mortality and affects plant growth and flower organ morphology in surviving plants.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Note: Binds 1 Mg2+ per trimer.
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | identical protein binding | |
Molecular Function | magnesium ion binding | |
Biological Process | DNA repair | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9STG6
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000401366 | 1-166 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||
Sequence: MACVNEPSPKLQKLDRNGIHGDSSPSPFFKVKKLSEKAVIPTRGSPLSAGYDLSSAVDSKVPARGKALIPTDLSIAVPEGTYARIAPRSGLAWKHSIDVGAGVIDADYRGPVGVILFNHSDADFEVKFGDRIAQLIIEKIVTPDVVEVDDLDETVRGDGGFGSTGV |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MACVNEPSPKLQKLDRNGIHGDSS |
Sequence similarities
Belongs to the dUTPase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length166
- Mass (Da)17,557
- Last updated2000-05-01 v1
- Checksum5487738DF4A55BFF
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I9LM85 | A0A1I9LM85_ARATH | DUT1 | 207 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL096859 EMBL· GenBank· DDBJ | CAB51171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE78222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF370334 EMBL· GenBank· DDBJ | AAK44149.1 EMBL· GenBank· DDBJ | mRNA | ||
AY062989 EMBL· GenBank· DDBJ | AAL34163.1 EMBL· GenBank· DDBJ | mRNA |