Q9STG6 · DUT_ARATH

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.

Miscellaneous

Silencing of DUT leads to high seedling mortality and affects plant growth and flower organ morphology in surviving plants.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Binds 1 Mg2+ per trimer.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site138Mg2+ (UniProtKB | ChEBI); ligand shared between trimeric partners

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionidentical protein binding
Molecular Functionmagnesium ion binding
Biological ProcessDNA repair
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase
    • dUTP-pyrophosphatase-like 1 (AtDUT1)

Gene names

    • Name
      DUT
    • Synonyms
      DUT1
    • ORF names
      T6H20.30
    • Ordered locus names
      At3g46940

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9STG6

Proteomes

Organism-specific databases

Genome annotation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004013661-166Deoxyuridine 5'-triphosphate nucleotidohydrolase

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    166
  • Mass (Da)
    17,557
  • Last updated
    2000-05-01 v1
  • Checksum
    5487738DF4A55BFF
MACVNEPSPKLQKLDRNGIHGDSSPSPFFKVKKLSEKAVIPTRGSPLSAGYDLSSAVDSKVPARGKALIPTDLSIAVPEGTYARIAPRSGLAWKHSIDVGAGVIDADYRGPVGVILFNHSDADFEVKFGDRIAQLIIEKIVTPDVVEVDDLDETVRGDGGFGSTGV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I9LM85A0A1I9LM85_ARATHDUT1207

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL096859
EMBL· GenBank· DDBJ
CAB51171.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE78222.1
EMBL· GenBank· DDBJ
Genomic DNA
AF370334
EMBL· GenBank· DDBJ
AAK44149.1
EMBL· GenBank· DDBJ
mRNA
AY062989
EMBL· GenBank· DDBJ
AAL34163.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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