Q9SSM4 · CHM1B_ARATH

Function

function

Involved in ESCRT-dependent multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Mediates the MVB sorting of the auxin carriers PIN1, PIN2 and AUX1. Required for embryonic axis establishment and seedling growth (PubMed:19304934).
Required for autophagic degradation of plastid proteins. Promotes the efficient sequestration of cargo from plastids into autophagosomes. Mediates the efficient delivery of autophagic plastid bodies to the vacuole, but not into the cytoplasm (PubMed:25649438).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome membrane
Cellular Componentmitochondrion
Biological Processembryo development ending in seed dormancy
Biological Processembryonic axis specification
Biological Processendosome transport via multivesicular body sorting pathway
Biological Processprotein transport
Biological Processseedling development
Biological Processvacuolar transport

Keywords

Protein family/group databases

    • 3.A.31.1.2the endosomal sorting complexes required for transport iii (escrt-iii) family

Names & Taxonomy

Protein names

  • Recommended name
    ESCRT-related protein CHMP1B
  • Alternative names
    • Protein CHARGED MULTIVESICULAR BODY PROTEIN 1B
    • Protein CHROMATIN MODIFYING PROTEIN 1B
    • Vacuolar protein-sorting-associated protein 46.2

Gene names

    • Name
      CHMP1B
    • Synonyms
      VPS46.2
    • ORF names
      F3N23.23
    • Ordered locus names
      At1g73030

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SSM4
  • Secondary accessions
    • Q8LFG3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cytoplasm
Endosome membrane
; Peripheral membrane protein

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but double mutants chmp1a and chmp1b show embryo development defect.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004330271-203

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with CHMP1A and LIP5 (PubMed:20663085).
Interacts with VPS2.2 (PubMed:22010978).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil13-51
Coiled coil109-140
Region172-203Disordered
Compositional bias181-203Basic and acidic residues

Sequence similarities

Belongs to the SNF7 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,691
  • Last updated
    2000-05-01 v1
  • Checksum
    7E56E8D937B38CD2
MGNTDKLMNQIFDLKFTSKSLQRQSRKCEKEEKAEKLKVKKAIEKGNMDGARIYAENAIRKRSEQMNYLRLASRLDAVVARLDTQAKMTTITKSMTNIVKSLESSLATGNLQKMSETMDSFEKQFVNMEVQAEFMENAMAGSTSLSTPEGEVNSLMQQVADDYGLEVSVGLPQPAGHAIPTKTEEKVDEDDLSRRLAELKARG

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict63in Ref. 4; AAM61431
Compositional bias181-203Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC008017
EMBL· GenBank· DDBJ
AAD55650.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE35406.1
EMBL· GenBank· DDBJ
Genomic DNA
AY059851
EMBL· GenBank· DDBJ
AAL24333.1
EMBL· GenBank· DDBJ
mRNA
AY081673
EMBL· GenBank· DDBJ
AAM10235.1
EMBL· GenBank· DDBJ
mRNA
AY084868
EMBL· GenBank· DDBJ
AAM61431.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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