Q9SRZ4 · PRX2C_ARATH

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.

Catalytic activity

Kinetics

Vmax pH TEMPERATURE[C] NOTES EVIDENCE
8.9 nmol/min/mgfor H2O2

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site51Cysteine sulfenic acid (-SOH) intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionthioredoxin peroxidase activity
Biological Processcellular response to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-2C
  • EC number
  • Alternative names
    • Glutaredoxin-dependent peroxiredoxin
    • Peroxiredoxin IIC
    • Peroxiredoxin TPx2
    • Thioredoxin peroxidase 2C
    • Thioredoxin-dependent peroxidase 2

Gene names

    • Name
      PRXIIC
    • Synonyms
      TPX2
    • ORF names
      F12P19.13
    • Ordered locus names
      At1g65970

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SRZ4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002822801-162Peroxiredoxin-2C

Proteomic databases

Expression

Tissue specificity

Highly expressed in buds and flowers. Slightly expressed in green tissues. Also detected in pollen.

Induction

Highly induced by salt or oxidative stresses.

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-162Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Prx5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    162
  • Mass (Da)
    17,414
  • Last updated
    2000-05-01 v1
  • Checksum
    7EEBEA0B56666E0A
MAPITVGDVVPDGTISFFDENDQLQTVSVHSIAAGKKVILFGVPGAFTPTCSMSHVPGFIGKAEELKSKGIDEIICFSVNDPFVMKAWGKTYPENKHVKFVADGSGEYTHLLGLELDLKDKGLGIRSRRFALLLDNLKVTVANVESGGEFTVSSAEDILKAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF121356
EMBL· GenBank· DDBJ
AAD28243.1
EMBL· GenBank· DDBJ
mRNA
AC009513
EMBL· GenBank· DDBJ
AAF06057.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE34446.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332463
EMBL· GenBank· DDBJ
AAG48826.1
EMBL· GenBank· DDBJ
mRNA
BT003050
EMBL· GenBank· DDBJ
AAO23615.1
EMBL· GenBank· DDBJ
mRNA
AY084458
EMBL· GenBank· DDBJ
AAM61030.1
EMBL· GenBank· DDBJ
mRNA
AK227350
EMBL· GenBank· DDBJ
BAE99360.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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