Q9SIS4 · IP5P9_ARATH
- ProteinType IV inositol polyphosphate 5-phosphatase 9
- GeneIP5P9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids417 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3. Functions in salt stress response by regulating reactive oxygen species (ROS) production, endocytosis, Ca2+ influx and stress-responsive genes expression.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | inositol-polyphosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol phosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | |
Biological Process | cellular response to salt stress | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | regulation of clathrin-dependent endocytosis | |
Biological Process | regulation of reactive oxygen species metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameType IV inositol polyphosphate 5-phosphatase 9
- EC number
- Short namesAt5PTase9
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SIS4
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
Increased salt sensitivity with reduced production of reactive oxygen species (ROS), reduced Ca2+ influx, as well as decreased fluid-phase endocytosis.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 54 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000433259 | 1-417 | Type IV inositol polyphosphate 5-phosphatase 9 | |||
Sequence: MWPRLVANKILRKSLGSNNFVADFPPNTDQKLIEASGLADERSKSILHNQHKTTLLNYKVFVSTWNVGGIVPDDGLDMEDLLETHKTPCDIYVLGFQEVVPLRASNVLGSDNNKVSTKWNSLIRDALNKRARPHRDEDLSESKGINGISQDFRCIISKQMVGILITVWVRGDLWPYIRYPSVSCVGCGIMGCLGNKGSVSVRFQLHETTFCFVCSHLASGGRDRDERQRNSDVNEILARSSFPRGSSLDLPKKILDHDRVIFLGDLNYRISLPEEKTRLLVESKKWNILLENDQLRMEIMNGQIFRGWQEGIVKFAPTYKYVPNSDLYYGCITYKKDEKKRAPAWCDRIIWYGNGLKQHEYTRGETKISDHRPVKAIFTTEITVTRRGKKIRNFFFSDRFEERIGDIDSKDYSWIST |
Proteomic databases
Expression
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 258-273 | Catalytic 1 | ||||
Sequence: DRVIFLGDLNYRISLP | ||||||
Region | 339-354 | Catalytic 2 | ||||
Sequence: KKRAPAWCDRIIWYGN |
Sequence similarities
Belongs to the inositol polyphosphate 5-phosphatase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length417
- Mass (Da)47,924
- Last updated2000-05-01 v1
- Checksum13A4527DEC6A6B7B
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8AXI3 | A0A1P8AXI3_ARATH | T5PTASE9 | 425 | ||
A0A1P8AXD3 | A0A1P8AXD3_ARATH | T5PTASE9 | 408 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007069 EMBL· GenBank· DDBJ | AAD21781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC05514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX818920 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |