Q9SIK7 · PSNB_ARATH
- ProteinPresenilin-like protein At2g29900
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids397 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 198 | |||||
Sequence: D | ||||||
Active site | 318 | |||||
Sequence: D |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi-associated vesicle | |
Cellular Component | intracellular membrane-bounded organelle | |
Molecular Function | aspartic endopeptidase activity, intramembrane cleaving | |
Biological Process | Notch signaling pathway | |
Biological Process | protein processing |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePresenilin-like protein At2g29900
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SIK7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-17 | Cytoplasmic | ||||
Sequence: MDRNQRPRSILDSLGEE | ||||||
Transmembrane | 18-38 | Helical | ||||
Sequence: LIAILTPVSICMFTVVLLVCI | ||||||
Topological domain | 39-76 | Lumenal | ||||
Sequence: LNSDPSSSSASFSSIATAAYSESDSDSSWDKFVGALLN | ||||||
Transmembrane | 77-97 | Helical | ||||
Sequence: SVVFVAAITVATFVLVLLFYL | ||||||
Topological domain | 98-106 | Cytoplasmic | ||||
Sequence: RCVKFLKFY | ||||||
Transmembrane | 107-127 | Helical | ||||
Sequence: MGFSAFIVLGNLGGEILVLLI | ||||||
Topological domain | 128-135 | Lumenal | ||||
Sequence: DRFRFPID | ||||||
Transmembrane | 136-156 | Helical | ||||
Sequence: SITFLILLFNFSVVGVFAVFM | ||||||
Topological domain | 157-158 | Cytoplasmic | ||||
Sequence: SK | ||||||
Transmembrane | 159-179 | Helical | ||||
Sequence: FSILITQGYLVWIGVLVAYFF | ||||||
Topological domain | 180-188 | Lumenal | ||||
Sequence: TLLPEWTTW | ||||||
Transmembrane | 189-209 | Helical | ||||
Sequence: VLLVALALYDIAAVLLPVGPL | ||||||
Topological domain | 210-305 | Cytoplasmic | ||||
Sequence: RLLVEMAISRDEDIPALVYEARPVIRNDSRSVQRRVWREQRSSQNNANRNEVRVVESAEVEEEHVGSSERAEISVPLIDRRPEQAENSETFLEGIG | ||||||
Transmembrane | 306-326 | Helical | ||||
Sequence: LGSSGAIKLGLGDFIFYSVLV | ||||||
Topological domain | 327-336 | Lumenal | ||||
Sequence: GRAAMYDLMT | ||||||
Transmembrane | 337-357 | Helical | ||||
Sequence: VYACYLAIIAGLGITLMLLSV | ||||||
Topological domain | 358-366 | Cytoplasmic | ||||
Sequence: YQKALPALP | ||||||
Intramembrane | 367-387 | Helical | ||||
Sequence: VSIMLGVVFYFLARLLLEVFV | ||||||
Topological domain | 388-397 | Cytoplasmic | ||||
Sequence: VQCSSNLVMF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000073906 | 1-397 | Presenilin-like protein At2g29900 | |||
Sequence: MDRNQRPRSILDSLGEELIAILTPVSICMFTVVLLVCILNSDPSSSSASFSSIATAAYSESDSDSSWDKFVGALLNSVVFVAAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRFRFPIDSITFLILLFNFSVVGVFAVFMSKFSILITQGYLVWIGVLVAYFFTLLPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDIPALVYEARPVIRNDSRSVQRRVWREQRSSQNNANRNEVRVVESAEVEEEHVGSSERAEISVPLIDRRPEQAENSETFLEGIGLGSSGAIKLGLGDFIFYSVLVGRAAMYDLMTVYACYLAIIAGLGITLMLLSVYQKALPALPVSIMLGVVFYFLARLLLEVFVVQCSSNLVMF |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 363-365 | PAL | ||||
Sequence: PAL |
Domain
The PAL motif is required for normal active site conformation.
Sequence similarities
Belongs to the peptidase A22A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length397
- Mass (Da)44,012
- Last updated2000-05-01 v1
- ChecksumDE6804D6CA186783
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007113 EMBL· GenBank· DDBJ | AAD23630.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC08318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT028914 EMBL· GenBank· DDBJ | ABI49461.1 EMBL· GenBank· DDBJ | mRNA |