Q9SIK7 · PSNB_ARATH

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Features

Showing features for active site.

139750100150200250300350
TypeIDPosition(s)Description
Active site198
Active site318

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular ComponentGolgi-associated vesicle
Cellular Componentintracellular membrane-bounded organelle
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin-like protein At2g29900

Gene names

    • ORF names
      F6K5.3
    • Ordered locus names
      At2g29900

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SIK7
  • Secondary accessions
    • Q0IGK6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-17Cytoplasmic
Transmembrane18-38Helical
Topological domain39-76Lumenal
Transmembrane77-97Helical
Topological domain98-106Cytoplasmic
Transmembrane107-127Helical
Topological domain128-135Lumenal
Transmembrane136-156Helical
Topological domain157-158Cytoplasmic
Transmembrane159-179Helical
Topological domain180-188Lumenal
Transmembrane189-209Helical
Topological domain210-305Cytoplasmic
Transmembrane306-326Helical
Topological domain327-336Lumenal
Transmembrane337-357Helical
Topological domain358-366Cytoplasmic
Intramembrane367-387Helical
Topological domain388-397Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000739061-397Presenilin-like protein At2g29900

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, APH1 and PEN2 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif363-365PAL

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    397
  • Mass (Da)
    44,012
  • Last updated
    2000-05-01 v1
  • Checksum
    DE6804D6CA186783
MDRNQRPRSILDSLGEELIAILTPVSICMFTVVLLVCILNSDPSSSSASFSSIATAAYSESDSDSSWDKFVGALLNSVVFVAAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRFRFPIDSITFLILLFNFSVVGVFAVFMSKFSILITQGYLVWIGVLVAYFFTLLPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDIPALVYEARPVIRNDSRSVQRRVWREQRSSQNNANRNEVRVVESAEVEEEHVGSSERAEISVPLIDRRPEQAENSETFLEGIGLGSSGAIKLGLGDFIFYSVLVGRAAMYDLMTVYACYLAIIAGLGITLMLLSVYQKALPALPVSIMLGVVFYFLARLLLEVFVVQCSSNLVMF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007113
EMBL· GenBank· DDBJ
AAD23630.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08318.1
EMBL· GenBank· DDBJ
Genomic DNA
BT028914
EMBL· GenBank· DDBJ
ABI49461.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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