Q9SII9 · DSK2A_ARATH
- ProteinUbiquitin domain-containing protein DSK2a
- GeneDSK2A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids538 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | polyubiquitin modification-dependent protein binding |
Names & Taxonomy
Protein names
- Recommended nameUbiquitin domain-containing protein DSK2a
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SII9
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 61 | Abolishes interaction with RPN13. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 39 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000423179 | 1-538 | Ubiquitin domain-containing protein DSK2a | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous with a strong expression level in inflorescence.
Gene expression databases
Interaction
Subunit
Interacts with 'Lys-48'-linked polyubiquitin chains via its UBA domain. Interacts with RPN10 and RPN13. Interacts with PEX2 and PEX12.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9SII9 | PEX2 Q9CA86 | 3 | EBI-6860633, EBI-4470254 | |
BINARY | Q9SII9 | RUB2 Q8RUC6 | 3 | EBI-6860633, EBI-25522172 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-93 | Ubiquitin-like | |||
Region | 95-120 | Disordered | |||
Compositional bias | 97-120 | Polar residues | |||
Domain | 138-179 | STI1 1 | |||
Domain | 192-231 | STI1 2 | |||
Region | 289-316 | Disordered | |||
Domain | 357-394 | STI1 3 | |||
Domain | 398-433 | STI1 4 | |||
Domain | 491-535 | UBA | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length538
- Mass (Da)57,285
- Last updated2002-06-01 v2
- ChecksumAF2BF2BF36413DBD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 97-120 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007127 EMBL· GenBank· DDBJ | AAD25137.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF360159 EMBL· GenBank· DDBJ | AAK25869.1 EMBL· GenBank· DDBJ | mRNA | ||
AY042828 EMBL· GenBank· DDBJ | AAK68768.1 EMBL· GenBank· DDBJ | mRNA | ||
AY081450 EMBL· GenBank· DDBJ | AAM10012.1 EMBL· GenBank· DDBJ | mRNA | ||
AY113886 EMBL· GenBank· DDBJ | AAM44934.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228616 EMBL· GenBank· DDBJ | BAF00527.1 EMBL· GenBank· DDBJ | mRNA |