Q9SIA5 · DTX1_ARATH
- ProteinProtein DETOXIFICATION 1
- GeneDTX1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Efflux carrier for plant-derived alkaloids, antibiotics, heavy metal and other toxic compounds. Involved in cadmium detoxification. Requires probably a proton-motive force for the efflux.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | cadmium ion transport | |
Biological Process | sequestering of metal ion | |
Biological Process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein DETOXIFICATION 1
- Short namesAtDTX1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SIA5
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 35-55 | Helical | ||||
Sequence: AAPMATVTIAQYLLPVISVMV | ||||||
Transmembrane | 66-86 | Helical | ||||
Sequence: GVALANSFTNVTGFSIMCGLV | ||||||
Transmembrane | 117-137 | Helical | ||||
Sequence: IPICFLISILWLYIEKILISL | ||||||
Transmembrane | 146-166 | Helical | ||||
Sequence: IAGSYAFWLIPALFGQAIVIP | ||||||
Transmembrane | 184-204 | Helical | ||||
Sequence: AVTTLLFHVLVCWTLVFLFGL | ||||||
Transmembrane | 208-228 | Helical | ||||
Sequence: GPAMATSVSFWFYAVILSCYV | ||||||
Transmembrane | 260-280 | Helical | ||||
Sequence: AAMICLEWWLFEILILCSGLL | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: VLSICLTIETLHYVISAGVAA | ||||||
Transmembrane | 331-351 | Helical | ||||
Sequence: VLAGLCLWIVESAFFSILLFT | ||||||
Transmembrane | 370-390 | Helical | ||||
Sequence: VADLTPLLCLSFILDGFTAVL | ||||||
Transmembrane | 402-422 | Helical | ||||
Sequence: IGAWNNTVSYYLVGAPVGIYL | ||||||
Transmembrane | 433-453 | Helical | ||||
Sequence: LWCGVVVGSTVQATILAIVTA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405319 | 1-476 | Protein DETOXIFICATION 1 | |||
Sequence: MEEPFLLRDELLVPSQVTWHTNPLTVELKRVSRLAAPMATVTIAQYLLPVISVMVAGHNGELQLSGVALANSFTNVTGFSIMCGLVGALETLCGQAYGAKQYEKIGTYAYSAIASNIPICFLISILWLYIEKILISLGQDPEISRIAGSYAFWLIPALFGQAIVIPLSRFLLTQGLVIPLLFTAVTTLLFHVLVCWTLVFLFGLGCNGPAMATSVSFWFYAVILSCYVRFSSSCEKTRGFVSRDFVSSIKQFFQYGIPSAAMICLEWWLFEILILCSGLLPNPKLETSVLSICLTIETLHYVISAGVAAAVSTRVSNNLGAGNPQVARVSVLAGLCLWIVESAFFSILLFTCRNIIGYAFSNSKEVLDYVADLTPLLCLSFILDGFTAVLNGVARGSGWQHIGAWNNTVSYYLVGAPVGIYLAFSRELNGKGLWCGVVVGSTVQATILAIVTASINWKEQAEKARKRIVSTENRLA |
Proteomic databases
Expression
Tissue specificity
Ubiquitous. Highest expression in flowers and stems.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)51,845
- Last updated2000-05-01 v1
- Checksum1A6952FD82B14424
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007178 EMBL· GenBank· DDBJ | AAD28687.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC05791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT022022 EMBL· GenBank· DDBJ | AAY25434.1 EMBL· GenBank· DDBJ | mRNA | ||
BT026371 EMBL· GenBank· DDBJ | ABH04478.1 EMBL· GenBank· DDBJ | mRNA | ||
AK227153 EMBL· GenBank· DDBJ | BAE99196.1 EMBL· GenBank· DDBJ | mRNA |