Q9SHL8 · PILS5_ARATH
- ProteinProtein PIN-LIKES 5
- GenePILS5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids396 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | auxin efflux transmembrane transporter activity | |
Biological Process | auxin-activated signaling pathway | |
Biological Process | endoplasmic reticulum to cytosol auxin transport | |
Biological Process | intracellular auxin homeostasis | |
Biological Process | lateral root formation | |
Biological Process | regulation of growth rate | |
Biological Process | response to auxin |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein PIN-LIKES 5
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SHL8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-5 | Lumenal | ||||
Sequence: MGFWS | ||||||
Transmembrane | 6-26 | Helical | ||||
Sequence: LLEVASMPVIQVLFMSLVGAF | ||||||
Topological domain | 27-45 | Cytoplasmic | ||||
Sequence: MASDRCKLFPVEARNSMNK | ||||||
Transmembrane | 46-66 | Helical | ||||
Sequence: VVFVLFAPALMFANLAQTVTL | ||||||
Topological domain | 67-73 | Lumenal | ||||
Sequence: EDIISWW | ||||||
Transmembrane | 74-94 | Helical | ||||
Sequence: FMPVNMGLTFLIGGLLGWLVV | ||||||
Topological domain | 95-106 | Cytoplasmic | ||||
Sequence: KILKPPPYLEGL | ||||||
Transmembrane | 107-127 | Helical | ||||
Sequence: IVATCSAGNMGNLPIILVPAI | ||||||
Topological domain | 128-144 | Lumenal | ||||
Sequence: CDEDKSPFGNRSVCRTV | ||||||
Transmembrane | 145-165 | Helical | ||||
Sequence: GLSYASFSMALGGFYIWTYTF | ||||||
Topological domain | 166-229 | Cytoplasmic | ||||
Sequence: RLIKGSAMKVQAIEESEKIAIKSSNSDLEADHKTHLLGAPEDKENKVVKEKTGFWRKGVDFLHE | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: ILEELLAPPTLGAIIGFIFGA | ||||||
Topological domain | 251-273 | Lumenal | ||||
Sequence: VRWLRNLIIGDDAPLRIVQSTAK | ||||||
Transmembrane | 274-294 | Helical | ||||
Sequence: LLGDGTIPCMTIILGGNLIQG | ||||||
Topological domain | 295-312 | Cytoplasmic | ||||
Sequence: LRSSAVKPMVVLGIVCVR | ||||||
Transmembrane | 313-333 | Helical | ||||
Sequence: YIAMPIIGIGIVLTAANLGFL | ||||||
Topological domain | 334-337 | Lumenal | ||||
Sequence: PADP | ||||||
Transmembrane | 338-358 | Helical | ||||
Sequence: LFQYVLMLQFTLPPAMNIGTM | ||||||
Topological domain | 359-370 | Cytoplasmic | ||||
Sequence: TQLYNVAQDECS | ||||||
Transmembrane | 371-391 | Helical | ||||
Sequence: VLMLWTYLVAILALTVWSTIF | ||||||
Topological domain | 392-396 | Lumenal | ||||
Sequence: LHLLV |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Increased root growth and lateral root initiation.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000436500 | 1-396 | Protein PIN-LIKES 5 | |||
Sequence: MGFWSLLEVASMPVIQVLFMSLVGAFMASDRCKLFPVEARNSMNKVVFVLFAPALMFANLAQTVTLEDIISWWFMPVNMGLTFLIGGLLGWLVVKILKPPPYLEGLIVATCSAGNMGNLPIILVPAICDEDKSPFGNRSVCRTVGLSYASFSMALGGFYIWTYTFRLIKGSAMKVQAIEESEKIAIKSSNSDLEADHKTHLLGAPEDKENKVVKEKTGFWRKGVDFLHEILEELLAPPTLGAIIGFIFGAVRWLRNLIIGDDAPLRIVQSTAKLLGDGTIPCMTIILGGNLIQGLRSSAVKPMVVLGIVCVRYIAMPIIGIGIVLTAANLGFLPADPLFQYVLMLQFTLPPAMNIGTMTQLYNVAQDECSVLMLWTYLVAILALTVWSTIFLHLLV |
Proteomic databases
Expression
Tissue specificity
Expressed in seedlings, cauline leaves and flowers.
Induction
Up-regulated by auxin application.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length396
- Mass (Da)43,394
- Last updated2000-05-01 v1
- Checksum81A78C8A017CF67D
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 216 | in Ref. 4; AAM60930 | ||||
Sequence: K → E | ||||||
Sequence conflict | 311 | in Ref. 4; AAM60930 | ||||
Sequence: V → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC007584 EMBL· GenBank· DDBJ | AAD32907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06636.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06637.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK226321 EMBL· GenBank· DDBJ | BAE98473.1 EMBL· GenBank· DDBJ | mRNA | ||
AY084347 EMBL· GenBank· DDBJ | AAM60930.1 EMBL· GenBank· DDBJ | mRNA | ||
AK317010 EMBL· GenBank· DDBJ | BAH19704.1 EMBL· GenBank· DDBJ | mRNA |