Q9SGH2 · MBD9_ARATH
- ProteinMethyl-CpG-binding domain-containing protein 9
- GeneMBD9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2176 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Probable transcriptional regulator that acts as a histone acetyltransferase. Mediates the acetylation of histone H3 and H4 of target loci (e.g. FLC). Involved in an auxin-independent regulation of shoot branching and flowering time.
Catalytic activity
- acetyl-CoA + L-lysyl-[protein] = CoA + H+ + N6-acetyl-L-lysyl-[protein]
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | plasmodesma | |
Cellular Component | Swr1 complex | |
Molecular Function | histone acetyltransferase activity | |
Molecular Function | histone binding | |
Molecular Function | metal ion binding | |
Molecular Function | methyl-CpG binding | |
Biological Process | epigenetic regulation of gene expression | |
Biological Process | photoperiodism, flowering | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | secondary shoot formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethyl-CpG-binding domain-containing protein 9
- EC number
- Short namesAtMBD9; MBD09
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SGH2
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Over-methylated genomic DNA. Increased shoot branching and reduced transcription of FLC leading to early flowering, associated with a decrease in the acetylation level in histone H3 and H4 of FLC chromatin.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 143 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405285 | 1-2176 | Methyl-CpG-binding domain-containing protein 9 | |||
Sequence: MEPTDSTNEQLGDTKTAAVKEESRSFLGIDLNEIPTGATLGGGCTAGQDDDGEYEPVEVVRSIHDNPDPAPGAPAEVPEPDRDASCGACGRPESIELVVVCDACERGFHMSCVNDGVEAAPSADWMCSDCRTGGERSKLWPLGVKSKLILDMNASPPSDAEGYGAEETSDSRKHMLASSSCIGNSFDYAMMHSSFSSLGRGHASLEASGLMSRNTKMSMDALGSHNLGFGFPLNLNNSSLPMRFPSLDPSELFLQNLRHFISERHGVLEDGWRVEFRQPLNGYQLCAVYCAPNGKTFSSIQEVACYLGLAINGNYSCMDAEIRNENSLLQERLHTPKRRKTSRWPNNGFPEQKGSSVSAQLRRFPFNGQTMSPFAVKSGTHFQAGGSLSSGNNGCGCEEAKNGCPMQFEDFFVLSLGRIDIRQSYHNVNVIYPIGYKSCWHDKITGSLFTCEVSDGNSGPIFKVTRSPCSKSFIPAGSTVFSCPKIDEMVEQNSDKLSNRRDSTQERDDDASVEILLSEHCPPLGDDILSCLREKSFSKTVNSLRSEVDSSRVDFDKNLSYDQDHGVEIGDIVVEEDSLSDAWKKVSQKLVDACSIVLKQKGTLNFLCKHVDRETSEINWDTMNEKDNVILSLSKFCCSLAPCSVTCGEKDKSEFAAVVDALSRWLDQNRFGLDADFVQEMIEHMPGAESCTNYRTLKSRSSSSVPITVAEGALVVKPKGGENVKDEVFGEISRKAKKPKLNGGHGVRNLHPPPGRPMCLRLPPGLVGDFLQVSEVFWRFHEILGFEEAFSPENLEQELINPVFDGLFLDKPGKDDKRSEINFTDKDSTATKLFSLFDESRQPFPAKNTSASELKEKKAGDSSDFKISDSSRGSCVGALLTRAHISLLQVLICELQSKVAAFVDPNFDSGESRSRRGRKKDDSTLSAKRNKLHMLPVNEFTWPELARRYILSLLSMDGNLESAEIAARESGKVFRCLQGDGGLLCGSLTGVAGMEADSMLLAEAIKKISGSLTSENDVLSVEDDDSDGLDATETNTCSGDIPEWAQVLEPVKKLPTNVGTRIRKCVYEALERNPPEWAKKILEHSISKEIYKGNASGPTKKAVLSLLADIRGGDLVQRSIKGTKKRTYISVSDVIMKKCRAVLRGVAAADEDKVLCTLLGRKLLNSSDNDDDGLLGSPAMVSRPLDFRTIDLRLAAGAYDGSTEAFLEDVLELWSSIRVMYADQPDCVDLVATLSEKFKSLYEAEVVPLVQKLKDYRKLECLSAEMKKEIKDIVVSVNKLPKAPWDEGVCKVCGVDKDDDSVLLCDTCDAEYHTYCLNPPLIRIPDGNWYCPSCVIAKRMAQEALESYKLVRRRKGRKYQGELTRASMELTAHLADVMEEKDYWEFSAEERILLLKLLCDELLSSSLVHQHLEQCAEAIIEMQQKLRSLSSEWKNAKMRQEFLTAKLAKVEPSILKEVGEPHNSSYFADQMGCDPQPQEGVGDGVTRDDETSSTAYLNKNQGKSPLETDTQPGESHVNFGESKISSPETISSPGRHELPIADTSPLVTDNLPEKDTSETLLKSVGRNHETHSPNSNAVELPTAHDASSQASQELQACQQDLSATSNEIQNLQQSIRSIESQLLKQSIRRDFLGTDASGRLYWGCCFPDENPRILVDGSISLQKPVQADLIGSKVPSPFLHTVDHGRLRLSPWTYYETETEISELVQWLHDDDLKERDLRESILWWKRLRYGDVQKEKKQAQNLSAPVFATGLETKAAMSMEKRYGPCIKLEMETLKKRGKKTKVAEREKLCRCECLESILPSMIHCLICHKTFASDDEFEDHTESKCIPYSLATEEGKDISDSSKAKESLKSDYLNVKSSAGKDVAEISNVSELDSGLIRYQEEESISPYHFEEICSKFVTKDCNRDLVKEIGLISSNGIPTFLPSSSTHLNDSVLISAKSNKPDGGDSGDQVIFAGPETNVEGLNSESNMSFDRSVTDSHGGPLDKPSGLGFGFSEQKNKKSSGSGLKSCCVVPQAALKRVTGKALPGFRFLKTNLLDMDVALPEEALRPSKSHPNRRRAWRVFVKSSQSIYELVQATIVVEDMIKTEYLKNEWWYWSSLSAAAKISTLSALSVRIFSLDAAIIYDKPITPSNPIDETKPIISLPDQKSQPVSDSQERSSRVRRSGKKRKEPEGS |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in leaves, buds, flowers and stems.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, domain, coiled coil, motif, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MEPTDSTNEQLGDTKTAAVK | ||||||
Region | 28-85 | Disordered | ||||
Sequence: GIDLNEIPTGATLGGGCTAGQDDDGEYEPVEVVRSIHDNPDPAPGAPAEVPEPDRDAS | ||||||
Zinc finger | 83-133 | PHD-type 1 | ||||
Sequence: DASCGACGRPESIELVVVCDACERGFHMSCVNDGVEAAPSADWMCSDCRTG | ||||||
Zinc finger | 86-131 | RING-type 1; degenerate | ||||
Sequence: CGACGRPESIELVVVCDACERGFHMSCVNDGVEAAPSADWMCSDCR | ||||||
Domain | 258-327 | MBD | ||||
Sequence: RHFISERHGVLEDGWRVEFRQPLNGYQLCAVYCAPNGKTFSSIQEVACYLGLAINGNYSCMDAEIRNENS | ||||||
Domain | 403-456 | FYR N-terminal | ||||
Sequence: GCPMQFEDFFVLSLGRIDIRQSYHNVNVIYPIGYKSCWHDKITGSLFTCEVSDG | ||||||
Coiled coil | 491-511 | |||||
Sequence: EQNSDKLSNRRDSTQERDDDA | ||||||
Domain | 550-698 | FYR C-terminal | ||||
Sequence: SSRVDFDKNLSYDQDHGVEIGDIVVEEDSLSDAWKKVSQKLVDACSIVLKQKGTLNFLCKHVDRETSEINWDTMNEKDNVILSLSKFCCSLAPCSVTCGEKDKSEFAAVVDALSRWLDQNRFGLDADFVQEMIEHMPGAESCTNYRTLK | ||||||
Motif | 914-921 | Nuclear localization signal | ||||
Sequence: SRRGRKKD | ||||||
Repeat | 1098-1137 | Pumilio | ||||
Sequence: PTKKAVLSLLADIRGGDLVQRSIKGTKKRTYISVSDVIMK | ||||||
Motif | 1124-1131 | Nuclear localization signal | ||||
Sequence: KKRTYISV | ||||||
Domain | 1157-1228 | Bromo | ||||
Sequence: TLLGRKLLNSSDNDDDGLLGSPAMVSRPLDFRTIDLRLAAGAYDGSTEAFLEDVLELWSSIRVMYADQPDCV | ||||||
Coiled coil | 1251-1273 | |||||
Sequence: QKLKDYRKLECLSAEMKKEIKDI | ||||||
Motif | 1256-1263 | Nuclear localization signal | ||||
Sequence: YRKLECLS | ||||||
Zinc finger | 1287-1337 | PHD-type 2 | ||||
Sequence: EGVCKVCGVDKDDDSVLLCDTCDAEYHTYCLNPPLIRIPDGNWYCPSCVIA | ||||||
Zinc finger | 1290-1335 | RING-type 2; degenerate | ||||
Sequence: CKVCGVDKDDDSVLLCDTCDAEYHTYCLNPPLIRIPDGNWYCPSCV | ||||||
Motif | 1337-1344 | Nuclear localization signal | ||||
Sequence: AKRMAQEA | ||||||
Coiled coil | 1410-1437 | |||||
Sequence: QHLEQCAEAIIEMQQKLRSLSSEWKNAK | ||||||
Region | 1472-1553 | Disordered | ||||
Sequence: GCDPQPQEGVGDGVTRDDETSSTAYLNKNQGKSPLETDTQPGESHVNFGESKISSPETISSPGRHELPIADTSPLVTDNLPE | ||||||
Compositional bias | 1487-1532 | Polar residues | ||||
Sequence: RDDETSSTAYLNKNQGKSPLETDTQPGESHVNFGESKISSPETISS | ||||||
Region | 1565-1595 | Disordered | ||||
Sequence: GRNHETHSPNSNAVELPTAHDASSQASQELQ | ||||||
Compositional bias | 1566-1595 | Polar residues | ||||
Sequence: RNHETHSPNSNAVELPTAHDASSQASQELQ | ||||||
Coiled coil | 1588-1628 | |||||
Sequence: SQASQELQACQQDLSATSNEIQNLQQSIRSIESQLLKQSIR | ||||||
Motif | 1761-1768 | Nuclear localization signal | ||||
Sequence: EKRYGPCI | ||||||
Region | 2136-2176 | Disordered | ||||
Sequence: IDETKPIISLPDQKSQPVSDSQERSSRVRRSGKKRKEPEGS | ||||||
Compositional bias | 2158-2176 | Basic and acidic residues | ||||
Sequence: ERSSRVRRSGKKRKEPEGS |
Domain
The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9SGH2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length2,176
- Mass (Da)240,431
- Last updated2000-05-01 v1
- Checksum05DBD955D895C3D5
Q9SGH2-2
- Name2
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1487-1532 | Polar residues | ||||
Sequence: RDDETSSTAYLNKNQGKSPLETDTQPGESHVNFGESKISSPETISS | ||||||
Compositional bias | 1566-1595 | Polar residues | ||||
Sequence: RNHETHSPNSNAVELPTAHDASSQASQELQ | ||||||
Compositional bias | 2158-2176 | Basic and acidic residues | ||||
Sequence: ERSSRVRRSGKKRKEPEGS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC009325 EMBL· GenBank· DDBJ | AAF01531.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC010870 EMBL· GenBank· DDBJ | AAF24616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE73669.1 EMBL· GenBank· DDBJ | Genomic DNA |