Q9SG12 · CAMK6_ARATH

Function

function

May play a role in signal transduction pathways that involve calcium as a second messenger.

Catalytic activity

Activity regulation

Activated by calcium and calmodulin. Autophosphorylation may play an important role in the regulation of the kinase activity (By similarity).

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site148-156ATP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)
Active site270Proton acceptor
Binding site461Ca2+ 1 (UniProtKB | ChEBI)
Binding site500Ca2+ 2 (UniProtKB | ChEBI)
Binding site505Ca2+ 2 (UniProtKB | ChEBI)
Binding site538Ca2+ 3 (UniProtKB | ChEBI)
Binding site545Ca2+ 3 (UniProtKB | ChEBI)
Binding site566Ca2+ 4 (UniProtKB | ChEBI)
Binding site568Ca2+ 4 (UniProtKB | ChEBI)
Binding site570Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CDPK-related kinase 6
  • EC number
  • Short names
    AtCRK6
  • Alternative names
    • Calcium/calmodulin-dependent protein kinase CRK6

Gene names

    • Name
      CRK6
    • ORF names
      F2K15.230, T1G12.7
    • Ordered locus names
      At3g49370

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SG12

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00004205332-594
Modified residue310Phosphoserine
Modified residue352Phosphoserine; by CPK1, CPK10 and CPK34

Post-translational modification

Autophosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binds calmodulin (CaM) in a calcium-dependent manner.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-126Disordered
Compositional bias24-59Polar residues
Domain142-404Protein kinase
Region408-438Autoinhibitory domain
Region427-447Calmodulin binding (CaMBD)
Domain445-480EF-hand 1
Domain481-516EF-hand 2
Domain517-556EF-hand 3
Domain557-586EF-hand 4

Domain

There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain, an autoinhibitory (junction) domain and a calmodulin-like domain. The autoinhibitory domain (408-438) inactivates kinase activity under calcium-free conditions (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    66,372
  • Last updated
    2000-05-01 v1
  • Checksum
    2B170246FB708FB9
MGHCYSRNISTVDDDDEIPSATAQLPHRSHQNHHQTSSSSSIPQSPATSEVNPYNISPFQSPLPAGVAPSPARTPGRKFKWPFPPPSPAKPIMAALRRRRGTAPHPRDGPIPEDSEAGGSGGGIGERLDKNFGFAKNFEGKYELGREVGRGHFGHTCWAKAKKGKIKGQTVAVKIISKSKMTSALSIEDVRREVKLLKALSGHSHMVKFYDVFEDSDNVFVVMELCEGGELLDSILARGGRYPEAEAKRILVQILSATAFFHLQGVVHRDLKPENFLFTSKNEDAVLKVIDFGLSDYARFDQRLNDVVGSAYYVAPEVLHRSYSTEADIWSIGVISYILLCGSRPFYGRTESAIFRCVLRANPNFDDLPWPSISPIAKDFVKRLLNKDHRKRMTAAQALAHPWLRDENPGLLLDFSIYKLVKSYIRASPFRRAALKSLSKAIPEEELVFLKAQFMLLEPEDGGLHLHNFTTALTRYATDAMIESRLPDILNMMQPLAHKKLDFEEFCAASVSVYQLEALEEWEQIATVAFEHFESEGSRAISVQELAEEMSLGPNAYPLLKDWIRSLDGKLNFLGYAKFLHGVTVRSSSSRPMR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-59Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC012329
EMBL· GenBank· DDBJ
AAG52176.1
EMBL· GenBank· DDBJ
Genomic DNA
AL132956
EMBL· GenBank· DDBJ
CAB66416.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE78533.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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